No apparent difference in suicide risk between older and newer antidepressants although older drugs may increase risk of suicide attempt during the first month of treatment

2006 ◽  
Vol 9 (3) ◽  
pp. 82-82 ◽  
Author(s):  
K. P Ebmeier
Keyword(s):  
Suicide Attempt ◽  
Suicide Risk ◽  
Apparent Difference ◽  
Increase Risk

Nearly Lethal Resuscitated Suicide Attempters Have No Low Serum Levels of Cholesterol and Triglycerides

2010 ◽  
Vol 106 (3) ◽  
pp. 785-790 ◽  
Author(s):  
Maurizio Pompili ◽  
David Lester ◽  
Marco Innamorati ◽  
Paolo Girardi ◽  
Roberto Tatarelli
Keyword(s):  
Suicide Attempt ◽  
Mood Disorders ◽  
Serum Cholesterol ◽  
Suicide Risk ◽  
Suicide Attempts ◽  
Serum Levels ◽  
Small Sample ◽  
Major Depressive ◽  
Lower Serum ◽  
Lower Serum Cholesterol

To verify the hypothesis that suicide attempts are associated with lower serum cholesterol and triglyceride levels of patients with mood disorders, 26 patients with mood disorders (bipolar disorder and major depressive disorder) were admitted after a medically serious suicide attempt to the emergency department and then hospitalized in the psychiatric unit of the Sant'Andrea Hospital (Rome, Italy). Controls were 87 patients who had not made a recent suicide attempt. Attempters and nonattempters did not differ in the levels of serum cholesterol or triglycerides. Indeed, attempters had nonsignificantly higher serum levels of cholesterol and lower serum levels of triglycerides. The use of biologic indicators such as levels of serum cholesterol and triglycerides in the prediction of suicide risk in mood disorders was not fully supported from this small sample.

Suicide attempts preceding completed suicide

1998 ◽  
Vol 173 (6) ◽  
pp. 531-535 ◽  
Author(s):  
Erkki T. Isometsä ◽  
Jouko K. Lönnqvist
Keyword(s):  
Suicide Attempt ◽  
Suicide Prevention ◽  
Suicide Risk ◽  
Suicide Attempts ◽  
Early Recognition ◽  
Preventive Measure ◽  
Time Interval ◽  
Psychological Autopsy ◽  
Autopsy Study ◽  
History Of

BackgroundThis study investigated three questions with major implications for suicide prevention: the sensitivity of the history of previous suicide attempt(s) as an indicator of suicide risk, the time interval from a preceding suicide attempt to the fatal one, and switching of suicide methods by those eventually completing suicide.MethodThe lifetime history of suicide attempts and the methods the victims (n=1397) used were examined in a nationwide psychological autopsy study comprising all suicides in Finland within a 12-month research period in 1987–1988.ResultsOverall, 56% of suicide victims were found to have died at their first suicide attempt, more males (62%) than females (38%). In 19% of males and 39% of females the victim had made a non-fatal attempt during the final year. Of the victims with previous attempts, 82% had used at least two different methods in their suicide attempts (the fatal included).ConclusionsMost male and a substantial proportion of female suicides die in their first suicide attempt, a fact that necessitates early recognition of suicide risk, particularly among males. Recognition of periods of high suicide risk on the grounds of recent non-fatal suicide attempts is likely to be important for suicide prevention among females. Subjects completing suicide commonly switch from one suicide method to another, a finding that weakens but does not negate the credibility of restrictions on the availability of lethal methods as a preventive measure.

Suicide risk with selective serotonin reuptake inhibitors and other new-generation antidepressants in adults: a systematic review and meta-analysis of observational studies

2021 ◽  
pp. jech-2020-214611
Author(s):  
Michael P Hengartner ◽  
Simone Amendola ◽  
Jakob A Kaminski ◽  
Simone Kindler ◽  
Tom Bschor ◽  
...  
Keyword(s):  
Systematic Review ◽  
Suicide Attempt ◽  
Publication Bias ◽  
Serotonin Reuptake ◽  
Observational Studies ◽  
Suicide Risk ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Treatment Indications ◽  
Trim And Fill ◽  
New Generation

BackgroundThere is ongoing controversy whether antidepressant use alters suicide risk in adults with depression and other treatment indications.MethodsSystematic review of observational studies, searching MEDLINE, PsycINFO, Web of Science, PsycARTICLES and SCOPUS for case–control and cohort studies. We included studies on depression and various indications unspecified (including off-label use) reporting risk of suicide and/or suicide attempt for adult patients using selective serotonin reuptake inhibitors (SSRI) and other new-generation antidepressants relative to non-users. Effects were meta-analytically aggregated with random-effects models, reporting relative risk (RR) estimates with 95% CIs. Publication bias was assessed via funnel-plot asymmetry and trim-and-fill method. Financial conflict of interest (fCOI) was defined present when lead authors’ professorship was industry-sponsored, they received industry-payments, or when the study was industry-sponsored.ResultsWe included 27 studies, 19 on depression and 8 on various indications unspecified (n=1.45 million subjects). SSRI were not definitely related to suicide risk (suicide and suicide attempt combined) in depression (RR=1.03, 0.70–1.51) and all indications (RR=1.19, 0.88–1.60). Any new-generation antidepressant was associated with higher suicide risk in depression (RR=1.29, 1.06–1.57) and all indications (RR=1.45, 1.23–1.70). Studies with fCOI reported significantly lower risk estimates than studies without fCOI. Funnel-plots were asymmetrical and imputation of missing studies with trim-and-fill method produced considerably higher risk estimates.ConclusionsExposure to new-generation antidepressants is associated with higher suicide risk in adult routine-care patients with depression and other treatment indications. Publication bias and fCOI likely contribute to systematic underestimation of risk in the published literature.RegistrationOpen Science Framework, https://osf.io/eaqwn/

A Comparison of Suicide Risk Scales in Predicting Repeat Suicide Attempt and Suicide

2019 ◽  
Vol 80 (6) ◽  
Author(s):  
Åsa U. Lindh ◽  
Marie Dahlin ◽  
Karin Beckman ◽  
Lotta Strömsten ◽  
Jussi Jokinen ◽  
...  
Keyword(s):  
Suicide Attempt ◽  
Suicide Risk

Race, Age, and Lack of Insurance Increase Risk of Suicide Attempt in Trauma Patients

2020 ◽  
pp. 1-15
Author(s):  
Jamie E. Temko ◽  
Areg Grigorian ◽  
Cristobal Barrios ◽  
Michael Lekawa ◽  
Larry Nahmias ◽  
...  
Keyword(s):  
Suicide Attempt ◽  
Trauma Patients ◽  
Increase Risk

Seriousness of Suicide Attempt and Future Risk of Suicide: A Comment on Card's Paper

1977 ◽  
Vol 8 (2) ◽  
pp. 141-149 ◽  
Author(s):  
D. J. Pallis ◽  
B. M. Barraclough
Keyword(s):  
Suicide Attempt ◽  
Suicide Risk ◽  
Alternative Analysis ◽  
Suicide Methods ◽  
Increased Risk ◽  
The Future ◽  
Future Risk ◽  
Threat To Life

Card (1974) distinguished between the lethality of suicide methods and suicide risk. According to her interpretation of her data the two variables were clearly distinct. This report reconsiders Card's data and tests a revised hypothesis on a different set of data. The conclusion that a serious threat to life resulting from a suicide attempt indicates an increased risk of suicide in the future is consistent with previous work as well as with Card's data, provided an alternative analysis is adopted.

scholarly journals Systemic inflammation and suicide risk: cohort study of 419 527 Korean men and women

2018 ◽  
Vol 72 (7) ◽  
pp. 572-574 ◽  
Author(s):  
G David Batty ◽  
Keum Ji Jung ◽  
Sunmi Lee ◽  
Joung Hwan Back ◽  
Sun Ha Jee
Keyword(s):  
Systemic Inflammation ◽  
Suicide Risk ◽  
Positive Association ◽  
Suicide Mortality ◽  
Risk Of Death ◽  
Induced Mood ◽  
Increase Risk ◽  
Strong Positive Association ◽  
The Relationship ◽  
Mortality Surveillance

BackgroundData from only one study have been used to examine the relationship between systemic inflammation and later suicide risk, and a strong positive association was apparent. More research is needed, particularly looking at gender, not least because women are seemingly more vulnerable to inflammation-induced mood changes than men.MethodsThe Korean Cancer Prevention Study had a cohort of over 1 million individuals aged 30–95 years at baseline examination between 1992 and 1995, when white blood cell count, our marker of systemic inflammation, was assessed.ResultsA mean of 16.6 years of mortality surveillance gave rise to 1010 deaths from suicide in 106 643 men, and 1019 deaths from suicide in 312 884 women. There was little evidence of an association between our inflammation marker and suicide mortality in men after multiple adjustments. In women, however, those in the second inflammation quartile and higher experienced around 30% increase risk of death (HR 1.35; 95% CI: 1.11–1.64).ConclusionsHigher levels of systemic inflammation were moderately related to an elevated risk of suicide death in women but not in men.

scholarly journals An approach for Risk Assessment Score of Suicide Attempt (RASSA)

2021 ◽  
Author(s):  
Ana Fructuoso ◽  
Inmaculada Fierro ◽  
María-Isabel Jiménez-Serranía ◽  
Alfonso Carvajal Garcia-Pando
Keyword(s):  
Risk Factors ◽  
Risk Assessment ◽  
Suicide Attempt ◽  
Suicide Risk ◽  
Psychiatric Patients ◽  
Opioid Analgesics ◽  
Health Records ◽  
Assessment Score ◽  
Somatic Comorbidity ◽  
Clinical Records

Abstract Background: Suicide remains a leading cause of death and psychiatric population is often at increased risk for suicide. Therefore, there is a persistent need for well-designed clinical instruments that allows us to identify relevant risk factors. Our study aims to improve patient follow-up and identify possible suicide risk markers from a passage to self-harm among hospitalized psychiatric patients. Methods: This case-control study included the review of psychiatric, sociodemographic, drug use, and other health-related data, retrieved from 1,680 psychiatric patients’ health records. Differences between comparative groups were examined, and stepwise logistic regression analyses were performed to identify suicide risk factors within this population.Results: From the analysis of 560 suicide attempters’ clinical records, thirteen risk items were included in our final model, named as Risk Assessment Score of Suicide Attempt (RASSA). The factors that scored the highest in this model were ‘not taking antipsychotic medication’, ‘somatic comorbidity’, and ‘a family history of suicide’. Suffering from depression has a high score, and treatment with selective serotonin reuptake inhibitors (SSRIs) is also involved in the risk of a suicide attempt. Regarding medication use, opioid analgesics decreased the risk score, while taking non-opioid analgesics increased it. In terms of commonly abused substances, alcohol, cocaine, and amphetamine dependence increased the score. A higher risk was also associated with cannabis dependence, while tobacco use reduced it. As for demographics, the risk was significantly greater for women and subjects who were unmarried. Conclusions: The proposed model of risk assessment score of suicide attempt (RASSA) offers the possibility of establishing a suicide attempt risk based on data directly gathered from the health records of psychiatric patients. Therefore, it might be used as an initial screening test before patient evaluation and psychometric tests.

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