Combination therapy with long-acting  -agonists plus inhaled corticosteroids is no more effective than LABA monotherapy for mortality outcomes and severe exacerbations in moderate to very severe COPD and is associated with serious adverse effects

P. A. Frith

doi:10.1136/ebm1050

Combination therapy with long-acting -agonists plus inhaled corticosteroids is no more effective than LABA monotherapy for mortality outcomes and severe exacerbations in moderate to very severe COPD and is associated with serious adverse effects

Evidence-Based Medicine ◽

10.1136/ebm1050 ◽

2010 ◽

Vol 15 (3) ◽

pp. 78-79

Author(s):

P. A. Frith

Keyword(s):

Adverse Effects ◽

Combination Therapy ◽

Inhaled Corticosteroids ◽

Long Acting ◽

Severe Copd

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The effect of Combination Therapy of Inhaled Corticosteroids and Long-acting Beta2-agonists on Acute Exacerbation in Moderate to Severe COPD Patients

Tuberculosis and Respiratory Diseases ◽

10.4046/trd.2005.59.2.164 ◽

2005 ◽

Vol 59 (2) ◽

pp. 164

Author(s):

Hye Cheol Jeong ◽

Eun Sil Ha ◽

Jin Yong Jung ◽

Kyung Ju Lee ◽

Seung Hyeun Lee ◽

...

Keyword(s):

Combination Therapy ◽

Acute Exacerbation ◽

Inhaled Corticosteroids ◽

Copd Patients ◽

Long Acting ◽

Severe Copd

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Combination Therapy of Inhaled Corticosteroids and Long-Acting β2- Adrenergics In Management of Patients with Chronic Obstructive Pulmonary Disease

Current Pharmaceutical Design ◽

10.2174/1381612043382990 ◽

2004 ◽

Vol 10 (28) ◽

pp. 3547-3560 ◽

Cited By ~ 6

Author(s):

Don Sin ◽

Malcolm Johnson ◽

Wen Gan ◽

S. F. Man

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Combination Therapy ◽

Pulmonary Disease ◽

Inhaled Corticosteroids ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Long Acting

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Economic Burden Associated with Receiving Inhaled Corticosteroids with Leukotriene Receptor Antagonists or Long-Acting Beta Agonists as Combination Therapy in Older Adults

Journal of Managed Care & Specialty Pharmacy ◽

10.18553/jmcp.2018.24.5.478 ◽

2018 ◽

Vol 24 (5) ◽

pp. 478-486

Author(s):

Shoroq M. Altawalbeh ◽

Carolyn T. Thorpe ◽

Janice C. Zgibor ◽

Sandra Kane-Gill ◽

Yihuang Kang ◽

...

Keyword(s):

Older Adults ◽

Combination Therapy ◽

Economic Burden ◽

Inhaled Corticosteroids ◽

Receptor Antagonists ◽

Leukotriene Receptor Antagonists ◽

Beta Agonists ◽

Leukotriene Receptor ◽

Long Acting

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Molecular Mechanisms of Combination Therapy With Inhaled Corticosteroids and Long-Acting β-Agonists

CHEST Journal ◽

10.1378/chest.09-0354 ◽

2009 ◽

Vol 136 (4) ◽

pp. 1095-1100 ◽

Cited By ~ 25

Author(s):

Judith L. Black ◽

Brian G.G. Oliver ◽

Michael Roth

Keyword(s):

Combination Therapy ◽

Molecular Mechanisms ◽

Inhaled Corticosteroids ◽

Long Acting

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The Comparative Effectiveness Of Inhaled Corticosteroids, Long Acting Beta Agonists, And Combination Therapy In A Cohort Of Veterans With Chronic Obstructive Pulmonary Disease

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3726 ◽

2012 ◽

Author(s):

Nathan Parker ◽

Jane Uman ◽

David H. Au

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Combination Therapy ◽

Pulmonary Disease ◽

Comparative Effectiveness ◽

Inhaled Corticosteroids ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Beta Agonists ◽

Long Acting

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Comparison Of Rates Of Prescribing Oral Corticosteroids For Asthma Exacerbations Between Step-Down Therapy Approaches Among Initiators Of Inhaled Corticosteroids and Long-Acting Beta-Agonist Combination Therapy

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2013.12.635 ◽

2014 ◽

Vol 133 (2) ◽

pp. AB177

Author(s):

Ayad K. Ali ◽

Almut Winterstein ◽

Leslie Hendeles ◽

Xiaomin Lu ◽

Richard Segal ◽

...

Keyword(s):

Combination Therapy ◽

Inhaled Corticosteroids ◽

Beta Agonist ◽

Asthma Exacerbations ◽

Oral Corticosteroids ◽

Step Down ◽

Long Acting

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Physicians’ attitudes towards combination therapy with inhaled corticosteroids and long-acting ß2-agonists: an observational study in UK specialist care

Pragmatic and Observational Research ◽

10.2147/por.s24674 ◽

2011 ◽

pp. 25 ◽

Cited By ~ 1

Author(s):

Mike Thomas ◽

Haughney ◽

David Price

Keyword(s):

Combination Therapy ◽

Observational Study ◽

Inhaled Corticosteroids ◽

Specialist Care ◽

Long Acting

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Advances in Asthma and COPD Treatment: Combination Therapy with Inhaled Corticosteroids and Long-Acting β2-Agonists.

Current Pharmaceutical Design ◽

10.2174/138161206778194187 ◽

2006 ◽

Vol 12 (25) ◽

pp. 3261-3279 ◽

Cited By ~ 45

Author(s):

A. Miller-Larsson ◽

O. Selroos

Keyword(s):

Combination Therapy ◽

Inhaled Corticosteroids ◽

Treatment Combination ◽

Long Acting

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Mono- and Combination Therapy of Long-Acting Bronchodilators and Inhaled Corticosteroids in Advanced COPD

Seminars in Respiratory and Critical Care Medicine ◽

10.1055/s-0030-1254072 ◽

2010 ◽

Vol 31 (03) ◽

pp. 321-333 ◽

Cited By ~ 18

Author(s):

Jill Ohar ◽

James Donohue

Keyword(s):

Combination Therapy ◽

Inhaled Corticosteroids ◽

Long Acting

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Patient-Reported Clinical Control and Peak-Flow: Effects of 30 Versus 6 Month Treatment with Inhaled Corticosteroids (ICS) with/without Long-Acting β2-Agonists (LABA) in Moderately Severe COPD.

10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2923 ◽

2009 ◽

Cited By ~ 1

Author(s):

JB Snoeck-Stroband ◽

TS Lapperre ◽

MM Gosman ◽

WJ Assendelft ◽

HM Boezen ◽

...

Keyword(s):

Peak Flow ◽

Inhaled Corticosteroids ◽

Clinical Control ◽

Patient Reported ◽

Flow Effects ◽

Long Acting ◽

Β2 Agonists ◽

Severe Copd

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