scholarly journals Effects of hormone therapy on quality of life in postmenopausal women with CAD differed according to menopausal symptoms

2002 ◽  
Vol 7 (6) ◽  
pp. 171-171
Author(s):  
M. Glenns
JAMA ◽  
2002 ◽  
Vol 287 (5) ◽  
pp. 591 ◽  
Author(s):  
Mark A. Hlatky ◽  
Derek Boothroyd ◽  
Eric Vittinghoff ◽  
Penny Sharp ◽  
Mary A. Whooley ◽  
...  

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
C. Bairey Merz ◽  
Marian Olson ◽  
Candace McClure ◽  
James Symons ◽  
George Sopko ◽  
...  

Background: Compared with men, women have more evidence of myocardial ischemia in the setting of no obstructive coronary artery disease (CAD). While low endogenous estrogen levels are associated with endothelial dysfunction, the role of low dose hormone therapy has not been fully evaluated in women suffering from myocardial ischemia and no obstructive CAD. Objective: This WISE ancillary trial evaluated the effect of low dose hormone therapy in postmenopausal women with myocardial ischemia and no obstructive CAD on: endothelial dysfunction, assessed by brachial artery reactivity, physical functional disability assessed by exercise testing, and quality of life assessed by cardiac symptoms and psychological questionnaires. Methods: Using a multicenter, randomized, placebo-controlled design, seventy-four participants with normal/minimally diseased epicardial coronary arteries (<50% luminal diameter stenosis) who fulfilled the inclusion criteria were planned to be randomized to receive either 1 mg norethindrone/10 mcg ethinyl estradiol (1/10 NA/EE) or placebo for twelve weeks. Baseline and exit brachial artery reactivity (BART), exercise stress testing, WISE psychosocial questionnaires, SF-36, blood lipids and hormone levels were evaluated. Results: Recruitment was closed prematurely due to failure to recruit in the year following publication of the Women’s Health Initiative hormone trial results. Of the 37 women randomized, 35 completed the study. While there was no difference in the frequency of chest pain between groups at the baseline visit, at study exit there was less frequent chest pain in the 1/10 NA/EE group compared to the placebo group (p=0.02). Women taking 1/10 NA/EE also showed a trend to improved BART and exercise tolerance, and had significantly fewer hot flashes/night sweats (p=0.003), less avoidance of intimacy (p=0.05), and borderline differences in sexual desire and vaginal dryness (p=0.06). Conclusion: Among postmenopausal women with myocardial ischemia and no obstructive CAD, hormone therapy with 1/10 NA/EE is associated with reduced chest pain symptoms, menopausal symptoms and improved quality of life with trends for improved endothelial function and exercise performance.


Neurology ◽  
2016 ◽  
Vol 87 (14) ◽  
pp. 1457-1463 ◽  
Author(s):  
Riley Bove ◽  
Charles C. White ◽  
Kathryn C. Fitzgerald ◽  
Tanuja Chitnis ◽  
Lori Chibnik ◽  
...  

2020 ◽  
Vol 15 (1) ◽  
pp. 43-49
Author(s):  
Dipti Koirala ◽  
Nirupa Thapa ◽  
Sarala Shrestha

Aim: To assess menopause specific quality of life of postmenopausal women. Method: This descriptive survey was carried out among postmenopausal women aged 40 to 60 years residing in a municipality of Kaski district of Nepal. Data was collected from 150 women meeting the criteria through face to face interview using a structured questionnaire consisting of socio-demographic items and Menopause-Specific Quality of Life (MENQOL) scale. Results: Respondents’ mean age and SD was 52.83±4.19 years and their mean menopausal age and SD was 47.12±4.34 years. The most common menopausal symptom reported by the respondents was decrease in physical strength (82.70%) and the least frequent symptom was increase in facial hair (7.40%). The mean scores and SD of MENQOL for physical, psychosocial, sexual and vasomotor domains were 1.67±0.42, 1.46±0.42, 1.31±0.47 and 1.27±0.57 respectively. Significant differences were detected in vasomotor, psychosocial and physical domain score according to physical activity, living status and body mass index respectively (p=0.05). Conclusions: Based on findings, it is concluded that all the postmenopausal women tend to have at least one or more menopausal symptoms. Physical domain is the most affected domain of QOL among the postmenopausal women. The presence of menopausal symptoms affects the quality of life of women adversely that warrants focused teaching and counselling. Keywords: menopause, menopausal symptoms and menopause specific quality of life


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