scholarly journals Review: n-3 polyunsaturated fatty acids reduce fatal myocardial infarction, sudden death, and overall mortality in coronary artery disease

2002 ◽  
Vol 7 (5) ◽  
pp. 142-142
Author(s):  
J. A Simon
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Coronary Artery ◽  
Sudden Death ◽  
Polyunsaturated Fatty Acids ◽  
Artery Disease ◽  
Fatal Myocardial Infarction ◽  
Overall Mortality

We-P14:465 The association of polyunsaturated fatty acids and blood pressure in men with coronary artery disease

2006 ◽  
Vol 7 (3) ◽  
pp. 449
Author(s):  
M. Stolyhwo Gofron ◽  
J. Bellwon ◽  
W. Sobiezewski ◽  
D. Ciecwierz ◽  
A. Rynkiewicz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Coronary Artery ◽  
Polyunsaturated Fatty Acids ◽  
Artery Disease

scholarly journals Cigarette smoking and non-fatal myocardial infarction in women: is the relation independent of coronary artery disease?

Heart ◽  
1989 ◽  
Vol 62 (4) ◽  
pp. 273-280 ◽  
Author(s):  
D S Freedman ◽  
H W Gruchow ◽  
J A Walker ◽  
S J Jacobsen ◽  
A J Anderson ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cigarette Smoking ◽  
Artery Disease ◽  
Fatal Myocardial Infarction

scholarly journals Causal effects of serum levels of n-3 or n-6 polyunsaturated fatty acids on coronary artery disease: Mendelian randomization study

2020 ◽  
Author(s):  
Sehoon Park ◽  
Soojin Lee ◽  
Yaerim Kim ◽  
Yeonhee Lee ◽  
Min Woo Kang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Linoleic Acid ◽  
Coronary Artery ◽  
Polyunsaturated Fatty Acids ◽  
Lower Risk ◽  
Mendelian Randomization ◽  
Causal Effects ◽  
Weighted Median ◽  
Artery Disease

AbstractBackgroundAdditional studies on the causal effects of 3-n and 6-n polyunsaturated fatty acids (PUFAs) on the risk of coronary artery disease (CAD) are warranted.MethodsThis Mendelian randomization (MR) study utilized a genetic instrument developed from previous genome-wide association studies for various serum 3-n and 6-n PUFA levels. First, we calculated the allele scores for genetic predisposition of PUFAs in individuals of European ancestry in the UK Biobank data (N=337,129). The allele score-based MR was obtained by regressing the allele scores to CAD risks. Second, summary-level MR was performed with the CARDIoGRAMplusC4D data for CAD (N=184,305). The inverse variance-weighted or Wald ratio method was the main analysis for the summary-level MR, and when multiple single nucleotide polymorphisms were utilized (e.g., linoleic acid), MR-Egger and weighted median methods were implemented as sensitivity analyses.ResultsHigher genetically predicted eicosapentaenoic acid and dihomo-gamma-linolenic acid levels were significantly associated with a lower risk of CAD both in the allele-score-based and summary-level MR analyses. Higher allele scores for linoleic acid level were significantly associated with lower CAD risks, and in the summary-level MR, the causal estimates by the MR-Egger and weighted median methods also indicated that higher linoleic acid levels cause a lower risk of CAD. Arachidonic acid was the 6-n PUFA that showed significant causal estimates for a higher risk of CAD. Higher docosapentaenoic acid and adrenic acid levels showed inconsistent findings in the MR analysis results.ConclusionsThis study supports the causal effects of certain 3-n and 6-n PUFA types on the risk of CAD.

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