scholarly journals Neurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study

BMJ ◽  
2021 ◽  
pp. n741
Author(s):  
Véronique Pierrat ◽  
Laetitia Marchand-Martin ◽  
Stéphane Marret ◽  
Catherine Arnaud ◽  
Valérie Benhammou ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Cohort Study ◽  
Outcome Measures ◽  
Low Socioeconomic Status ◽  
Gestational Age ◽  
Intelligence Quotient ◽  
Full Scale ◽  
Neurodevelopmental Outcomes ◽  
Neurodevelopmental Disabilities ◽  
Full Scale Intelligence Quotient

Abstract Objectives To describe neurodevelopment at age 5 among children born preterm. Design Population based cohort study, EPIPAGE-2. Setting France, 2011. Participants 4441 children aged 5½ born at 24-26, 27-31, and 32-34 weeks Main outcome measures Severe/moderate neurodevelopmental disabilities, defined as severe/moderate cerebral palsy (Gross Motor Function Classification System (GMFCS) ≥2), or unilateral or bilateral blindness or deafness, or full scale intelligence quotient less than minus two standard deviations (Wechsler Preschool and Primary Scale of Intelligence, 4th edition). Mild neurodevelopmental disabilities, defined as mild cerebral palsy (GMFCS-1), or visual disability ≥3.2/10 and <5/10, or hearing loss <40 dB, or full scale intelligence quotient (minus two to minus one standard deviation) or developmental coordination disorders (Movement Assessment Battery for Children, 2nd edition, total score less than or equal to the fifth centile), or behavioural difficulties (strengths and difficulties questionnaire, total score greater than or equal to the 90th centile), school assistance (mainstream class with support or special school), complex developmental interventions, and parents’ concerns about development. The distributions of the scores in contemporary term born children were used as reference. Results are given after multiple imputation as percentages of outcome measures with exact binomial 95% confidence intervals. Results Among 4441 participants, 3083 (69.4%) children were assessed. Rates of severe/moderate neurodevelopmental disabilities were 28% (95% confidence interval 23.4% to 32.2%), 19% (16.8% to 20.7%), and 12% (9.2% to 14.0%) and of mild disabilities were 38.5% (33.7% to 43.4%), 36% (33.4% to 38.1%), and 34% (30.2% to 37.4%) at 24-26, 27-31, and 32-34 weeks, respectively. Assistance at school was used by 27% (22.9% to 31.7%), 14% (12.1% to 15.9%), and 7% (4.4% to 9.0%) of children at 24-26, 27-31, and 32-34 weeks, respectively. About half of the children born at 24-26 weeks (52% (46.4% to 57.3%)) received at least one developmental intervention which decreased to 26% (21.8% to 29.4%) for those born at 32-34 weeks. Behaviour was the concern most commonly reported by parents. Rates of neurodevelopment disabilities increased as gestational age decreased and were higher in families with low socioeconomic status. Conclusions In this large cohort of children born preterm, rates of severe/moderate neurodevelopmental disabilities remained high in each gestational age group. Proportions of children receiving school assistance or complex developmental interventions might have a significant impact on educational and health organisations. Parental concerns about behaviour warrant attention.

scholarly journals Neuroprem 2: An Italian Study of Neurodevelopmental Outcomes of Very Low Birth Weight Infants

2021 ◽  
Vol 9 ◽  
Author(s):  
Licia Lugli ◽  
Luca Bedetti ◽  
Isotta Guidotti ◽  
Marisa Pugliese ◽  
Odoardo Picciolini ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cerebral Palsy ◽  
Birth Weight ◽  
Gestational Age ◽  
Functional Disability ◽  
Very Low Birth Weight ◽  
Neurodevelopmental Outcomes ◽  
Vlbw Infants ◽  
Neurodevelopmental Disabilities

Background: Despite the increased survival of preterm newborns worldwide, the risk of neurodevelopmental disabilities remains high. Analyzing the outcomes of the preterm population can identify risk factors and enable specific early interventions.Aims: Neuroprem is a prospective cohort study of very low birth weight (VLBW) infants that aims to evaluate the neurodevelopmental outcomes and risk factors for severe functional disability at 2 years of corrected age.Methods: Nine Italian neonatal intensive care units participated in the network. The Griffiths Mental Developmental Scales (GMDS-R) or the Bayley Scales of Infant and Toddler Development (BSDI III) and a neuro-functional evaluation (according to the International Classification of Disability and Health and Neuro-Functional Assessment, or NFA ICF-CY) were administered to VLBW infants at 24 months of corrected age. The primary outcome measure was severe functional disability, defined as cerebral palsy, bilateral blindness, deafness, an NFA ICF-CY of &gt;2, a BSDI III cognitive composite score of &lt;2 SD, or a GMDS-R global quotient score of &lt;2 SD. Perinatal risk factors for severe functional disability were assessed through multivariate logistic regression analysis.Results: Among 502 VLBW survivors who completed the 24-month follow-up, 48 (9.6%) presented severe functional disability, of whom 27 had cerebral palsy (5.4%). Rates of severe functional disability and cerebral palsy were higher in neonates with a lower gestational age (p &lt; 0.001). Overall, 147 infants (29.3%) were referred to neuromotor intervention. In the multivariate regression model, gestational age at birth OR 0.79; 95% CI 0.67–0.90; p = 0.001) and periventricular-intraventricular hemorrhage (OR 2.51; 95% CI 1.19–5.26; p = 0.015) were significantly associated with severe functional disability.Conclusion: Neuroprem 2 provides updated information on the neurodevelopmental outcomes of VLBW infants in a large Italian cohort. The overall rate of neurodevelopmental disabilities was quite lower than reported in the previous literature. These data indicate the need for structured follow-up programs from a national neonatal network perspective.

scholarly journals Influence of Maternal Preeclampsia on Neurodevelopmental Outcomes of Preterm Infants

2018 ◽  
Vol 24 (2) ◽  
pp. 99
Author(s):  
Halil Degirmencioglu ◽  
Birgul Say ◽  
Zeynep Ustunyurt ◽  
Serife Suna Oguz
Keyword(s):  
Cerebral Palsy ◽  
Preterm Infants ◽  
Gestational Age ◽  
Infant Development ◽  
Neurodevelopmental Outcome ◽  
Control Group ◽  
Neurodevelopmental Outcomes ◽  
Term Outcome ◽  
Long Term Outcome ◽  
The Mean

<p><strong>Objective:</strong> The aim of this study was to determine the neurodevelopmental outcome of preterm infants born to mothers with preeclampsia and to compare them with preterm controls.</p><p><strong>Study design:</strong> This was a retrospective, observational study in a large, tertiary, neonatal intensive care unit. Neurodevelopmental evaluations using Bayley Scales of Infant Development II were performed in 226 two-year-old infants with birth weight ≤1500 g and gestational age ≤32 weeks who were born to mothers with preeclampsia and in 493 infants who were born after normotensive pregnancies, matched for gestational age and gender.</p><p><strong>Results:</strong> The mean gestational ages of the infants in the preeclampsia and control groups were 29.9±2.3 weeks and 28.7±4.1 weeks, respectively (p&lt;0.001). A total of 372 infants with a mean age of 19.2±3.2 months were assessed for long-term outcome. The mean mental developmental index score was significantly higher, and the percentage of infants with cerebral palsy was significantly lower, in the preeclampsia group compared with the control group (p=0.03 and p=0.02, respectively). However, no overall significant differences in neurodevelopmental impairment rates were found between the two groups (p=0.08).</p><p><strong>Conclusion:</strong> Maternal preeclampsia seems to be a protector factor for the development of cerebral palsy in preterm infants.</p>

scholarly journals The Study of Intelligence Profiles Between Islands: A Preliminary Study Towards Norm Development

2016 ◽  
Vol 32 (1) ◽  
pp. 55-64
Author(s):  
Andika Octavianto ◽  
Mohammad A. G. Priadi ◽  
Magdalena S. Halim ◽  
Christiany Suwartono
Keyword(s):  
Intelligence Quotient ◽  
Normative Data ◽  
Age Groups ◽  
Educational Background ◽  
Full Scale ◽  
Statistical Analyses ◽  
Score Interpretation ◽  
Full Scale Intelligence Quotient ◽  
Preliminary Study ◽  
Healthy Participants

The aim of this study was to compare the intelligence of Indonesians residing in different islands using the Indonesian WAIS-IV (WAIS-IV-ID), which could be further considered in standardized norm development. Statistical analyses using ANOVAs were performed on the 15 subtests, four indices, and the Full-Scale Intelligence Quotient (FSIQ) of the WAIS-IV-ID. This study involved 506 healthy participants, the majority were females, in productive age-groups ranging from 16 to 59 years old, and from middle educational background. Results showed that three indices and 13 subtest scores had significant results and the sample from Java Island had significantly higher scores than the sample from Sumatra, Borneo, and Sulawesi Islands. Based on the conducted analysis, the normative data of the WAIS-IV-ID need to be classified differently between islands or between Java Island and Non-Java Island for more accurate score interpretation. The interpretations and implications of the findings are discussed.

Intellectual Development of Children Born of Mothers who Fasted in Ramadan during Pregnancy

2004 ◽  
Vol 74 (5) ◽  
pp. 374-380 ◽  
Author(s):  
Azizi ◽  
Sadeghipour ◽  
Siahkolah ◽  
Rezaei-Ghaleh
Keyword(s):  
Socioeconomic Status ◽  
Caesarean Section ◽  
Breast Feeding ◽  
Intelligence Quotient ◽  
Full Scale ◽  
Control Group ◽  
Case Group ◽  
Long Term Effects ◽  
Historical Cohort ◽  
Full Scale Intelligence Quotient

The long-term effects of Ramadan fasting during pregnancy on the brain development of the fetus are still not clear. The aim of this study was to evaluate the effects of maternal fasting during Ramadan on the intelligence quotient of their progeny. A historical cohort study was conducted on 191 children aged between 4 to 13 years, 98 whose mothers fasted throughout Ramadan when they were pregnant with their children (case group) and 93 children whose mothers did not fast (control group). The children were selected from 15 schools via a questionnaire filled out by their mothers. Detailed demographic, medical history, and socioeconomic status data were collected by interviewing the mothers. All children aged between 6 to 13 were administered the Wechsler Intelligence Scale for Children-Revised (WISC-R), and those aged between 4 to 6 were administered Wechsler Preschool and Primary Scales of Intelligence (WPPSI), and intelligence quotient was estimated. Cases included 47 boys and 51 girls aged 8.5 ± 2.5 years and controls included 44 boys and 49 girls aged 8.7 ± 2.5 years. There were no significant differences in sex and age between two groups. Among background and confounder variables, the percentage of Caesarean section and the duration of breast-feeding were significantly different between case and control groups; 29% Caesarean section in cases vs. 45% in controls (p < 0.05) and 17.2 ± 9 months breast-feeding for cases vs. 14.5 ± 9 months for controls (p < 0.05). There were no significant differences in socioeconomic status of families between the groups whereas socioeconomic status accounted for approximately 17% of the variances in the average of full-scale intelligence quotient scores. Adjusted mean and standard deviation of full-scale intelligence quotient scores, performance and verbal, were 111 ± 10, 109 ± 11 and 110 ± 11 for the case group and 112 ± 10, 110 ± 11 and 110 ± 11 for the control group respectively. No significant differences were observed between the IQ scores of the two groups. Fasting during gestation did not adversely affect IQ of children whose mothers had fasted during Ramadan while being pregnant.

scholarly journals Multiplicity and early gestational age contribute to an increased risk of cerebral palsy from assisted conception: a population-based cohort study

2010 ◽  
Vol 25 (8) ◽  
pp. 2115-2123 ◽  
Author(s):  
D. Hvidtjorn ◽  
J. Grove ◽  
D. Schendel ◽  
C. Svaerke ◽  
L. A. Schieve ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Cohort Study ◽  
Gestational Age ◽  
Population Based ◽  
Assisted Conception ◽  
Increased Risk
Sign in / Sign up

Export Citation Format

Share Document