scholarly journals Covid-19: CDC shortens isolation period as US cases hit record high

BMJ ◽  
2021 ◽  
pp. n3161 ◽  
Author(s):  
Janice Hopkins Tanne
Keyword(s):  
Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Ubiratan Cardinalli Adler ◽  
Maristela Schiabel Adler ◽  
Livia Mitchiguian Hotta ◽  
Ana Elisa Madureira Padula ◽  
Amarilys de Toledo Cesar ◽  
...  

Abstract Objectives To investigate the effectiveness and safety of homeopathic medicine Natrum muriaticum (LM2) for mild cases of COVID-19 in Primary Health Care. Trial design A randomized, two-armed (1:1), parallel, placebo-controlled, double-blind, clinical trial is being performed to test the following hypotheses: H0: homeopathic medicines = placebo (null hypothesis) vs. H1: homeopathic medicines ≠ placebo (alternative hypothesis) for mild cases of COVID-19 in Primary Care. Participants Setting: Primary Care of São Carlos – São Paulo – Brazil. One hundred participants aged 18 years or older, with Influenza-like symptoms and a positive RT-PCR for SARS-CoV-2. Willingness to give informed consent and to comply with the study procedures is also required. Exclusion criterium: severe acute respiratory syndrome. Intervention and comparator Homeopathy: 1 globule of Natrum muriaticum LM2 diluted in 20 mL of alcohol 30% and dispensed in a 30 ml bottle. Placebo: 20 mL of alcohol 30% dispensed in a 30 ml bottle. Posology: one drop taken orally every 4 hours (6 doses/day) while there is fever, cough, tiredness, or pain (headache, sore throat, muscle aches, chest pain, etc.) followed by one drop every 6 hours (4 doses/day) until the fourteenth day of use. The bottle of study medication should be submitted to 10 vigorous shakes (succussions) before each dose. Posology may be changed by telemedicine, with no break in blinding. Study medication should be maintained during home isolation. According to the Primary Care protocol, the home isolation period lasts until the 10th day after the appearance of the first symptom, or up to 72 hours without symptoms. Main outcomes The primary endpoint will be time to recovery, defined as the number of days elapsed before all COVID-19 Influenza-like symptoms are recorded as mild or absent during home isolation period. Secondary measures are recovery time for each COVID-19 symptom; score of the scale created for the study (COVID-Simile Scale); medicines used during follow-up; number of days of follow-up; number of visits to emergency services; number of hospitalizations; other symptoms and Adverse Events during home isolation period. Randomisation The study Statistician generated a block randomization list, using a 1:1 ratio of the two groups (denoted as A and B) and a web-based tool (http://www.random.org/lists). Blinding (masking) The clinical investigators, the statistician, the Primary Care teams, the study collaborators, and the participants will remain blinded from the identity of the two treatment groups until the end of the study. Numbers to be randomised (sample size) One hundred participants are planned to be randomized (1:1) to placebo (50) or homeopathy (50). Trial Status Protocol version/date May 21, 2020. Recruitment is ongoing. First participant was recruited/included on June 29,2020. Due to recruitment adaptations to Primary Care changes, the authors anticipate the trial will finish recruiting on April 10, 2021. Trial registration COVID-Simile Study was registered at the University Hospital Medical Information Network (UMIN - https://www.umin.ac.jp/ctr/index.htm) on June 1st, 2020, and the trial start date was June 15, 2020. Unique ID: UMIN000040602. Full protocol The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.


2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
S James ◽  
G Lafaurie ◽  
R Hafeez

Abstract Introduction The COVID-19 pandemic is here to last, and services must adapt to enable elective surgery to continue. Surgery involves high-risk aerosol generating procedures, potentially harmful to staff and patients. The current NICE guidance is for the patient to self-isolate for 72 hours prior to surgery. A question persists: Is 72-hour isolation the way forward in elective general surgery? Method In a DGH centre, using an anonymous questionnaire, we prospectively collected data on isolation for 36 elective general surgery patients during the 72h isolation period. The data was analysed to assess the concordance with isolation as well as patient's satisfaction with the process. Results 75% of patients were concordant with 72 hours of isolation pre-operatively. This was an increase from 35% when compared to patients questioned during the 14 day isolation period. The main factors contributing to isolation breech were visitors to the house and the mode of transport used to attend hospital. Conclusions The protocol is now for a COVID swab 72 hours pre-operatively followed by isolation until the operation. Our results show that still significant breaches in isolation remain and patients welfare is adversely affected during that period. Further research and consideration is needed to optimise the COVID isolation protocol.


2014 ◽  
Vol 11 (3) ◽  
pp. 1122-1129
Author(s):  
Baghdad Science Journal

The present study was included the isolation of Keratinophilic fungi from water samples taken from 19 indoor public swimming pools in Baghdad during four season (summer ,fall ,spring ,and winter). Isolation period was September 2011and September 2012 . Samples were collected from different places in swimming pool . Sixteen keratinophilic fungal species, belonging to twenty –one genera were isolated using Surface Dilution Plating (SDP) and Hair Bait Technique (HBT) . Aspergillus genus was the most frequent and occurrence (19.84%), followed by Trichophyton (11.60%) and Fusarium (7.59% ) . The most common fungal infection occurred in summer season (42.16%) , and the most frequent month manifestation of species occurred in August (17%) .


Pathogens ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 31 ◽  
Author(s):  
Carlos E. C. Matajira ◽  
Luisa Z. Moreno ◽  
Andre P. Poor ◽  
Vasco T. M. Gomes ◽  
Andressa C. Dalmutt ◽  
...  

Streptococcus suis remains an important challenge for the worldwide swine industry. Considering that Brazil is a major pork producer and exporter, proper monitoring of the pathogen and resistance rates are required. We present here the characterization of Brazilian S. suis strains isolated over a 15 year period by pulsed-field gel electrophoresis (PFGE) typing, capsular, virulence, and antimicrobial resistance profiling. Serotype prevalence revealed a predominance of serotype 2/½ followed by 3, 7, 1/14, 6, 8, 18, 28, and 27; the latter had not yet been reported in Brazil. Resistance profiling enabled the differentiation of nine profiles presenting resistance to three and up to eight antimicrobial classes. Even though an association between the most resistant strains and isolation year starting from 2009 was observed, a high frequency of multidrug-resistant strains isolated from 2001 to 2003 was also detected. This suggests that despite the isolation period, S. suis strains already presented high resistance selection pressure. A slight association of serotype 2/½ with some virulence profiles and PFGE pulsotypes was also identified. Nevertheless, no clonal dispersion or persistency of clones over the analyzed years and herds was detected.


Author(s):  
Daniel Mon-López ◽  
Alfonso de la Rubia Riaza ◽  
Mónica Hontoria Galán ◽  
Ignacio Refoyo Roman

The spread of COVID-19 has altered sport in Spain, forcing athletes to train at home. The objectives of the study were: (i) to compare training and recovery conditions before and during the isolation period in handball players according to gender and competitive level, and (ii) to analyse the impact of psychological factors during the isolation period. A total of 187 participants (66 women and 121 men) answered a Google Forms questionnaire about demographics, training, moods, emotional intelligence, and resilience sent using the snowball sampling technique. T-test and analysis of variance (ANOVA) were used to compare sport level and gender differences. Linear regressions were used to analyse the psychological influence on training. Handball players reduced training intensity (in the whole sample; p = 0.44), training volume (especially in professional female handball players; p < 0.001), and sleep quality (especially in professional male handball players; p = 0.21) and increased sleep hours (especially in non-professional female players; p = 0.006) during the isolation period. Furthermore, psychological factors affected all evaluated training and recovery conditions during the quarantine, except for sleep quantity. Mood, emotional intelligence, and resilience have an influence on physical activity levels and recovery conditions. In addition, training components were modified under isolation conditions at p < 0.001. We conclude that the COVID-19 isolation period caused reductions in training volume and intensity and decreased sleep quality. Furthermore, psychological components have a significant impact on training and recovery conditions.


2021 ◽  
Vol 20 (5) ◽  
pp. 574-584
Author(s):  
Angelo Melim Azevedo ◽  
Gregory Halle Petiot ◽  
Filipe Manuel Clemente ◽  
Fábio Yuzo Nakamura ◽  
Maxwell Viana Moraes-Neto ◽  
...  

This pandemic of COVID-19 has a major impact on people's lives, and several governments ordered extended quarantine and requested social isolation to contain the spread of COVID-19 and flatten its contagion curve. Soccer practice was also severely affected by these pandemic effects, including the postponement of several championships, which involve large audiences. In Brazil, the professional leagues restart the official matches (e.g., Brazilian National Fourth, Third, Second, and First Divisions Leagues). However, some youth academies have not yet restarted their professional activities. Therefore, home-based training can be a good option in these cases. Here, we outline the benefits of home workouts using a multidimensional approach. First, we provide practical recommendations for physical, psychological, and tactical training. Next, we propose an example of a home training program spanning one weekly microcycle for soccer players, using load control based on the rating of perceived exertion. We highlighted that is crucial to make all these exercises fun and entertaining during the self-isolation period. The home training recommendations discussed and proposed in this research can and should be adjusted by the coaches according to their own ideas and athletes' access to equipment (e.g., treadmills, flywheel training, virtual reality).


2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Luis A Rubio ◽  
James Peng ◽  
Susy Rojas ◽  
Susana Rojas ◽  
Emily Crawford ◽  
...  

Abstract Background Rapid coronavirus disease 2019 (COVID-19) diagnosis and isolation of infectious persons are critical to stopping forward transmission, and the care cascade framework can identify gaps in the COVID-19 response. Methods We described a COVID-19 symptom to isolation cascade and barriers among symptomatic persons who tested polymerase chain reaction positive for severe acute respiratory disease coronavirus 2 (SARS-CoV-2) at a low-barrier testing site serving a low-income Latinx community in San Francisco. Steps in the cascade are defined as days from symptom onset to test, test to result, and result to counseling on self-isolation. We examined SARS-CoV-2 cycle threshold (Ct) values to assess the likelihood of infectiousness on the day of testing and during missed isolation days. Results Among 145 persons, 97% were Latinx and 81% had an income of &lt;$50 000. The median time from symptom onset to isolation (interquartile range [IQR]) was 7 (5–10) days, leaving a median (IQR) of 3 (0–6) days of isolation. Eighty-three percent had moderate to high levels of virus (Ct &lt;33), but by disclosure 23% were out of their isolation period. The longest intervals were symptom onset to test (median [IQR], 4 [2–9] days) and test to results notification (median [IQR], 3 [2–4] days). Access to a test site was the most common barrier to testing, and food and income loss was the most common barrier to isolation. Conclusions Over half of the 10-day isolation period passed by the time of disclosure, and over a fifth of people were likely outside the window of infectiousness by the time they received results. Improvements in test access and turnaround time, plus support for isolation, are needed for epidemic control of SARS-CoV-2 in highly impacted communities.


2022 ◽  
Vol 75 (2) ◽  
Author(s):  
José Pinheiro Batista Medeiros ◽  
Eliane Tatsch Neves ◽  
Mardênia Gomes Vasconcelos Pitombeira ◽  
Sarah Vieira Figueiredo ◽  
Daniella Barbosa Campos ◽  
...  

ABSTRACT Objective: To describe the continuity of care for children with special healthcare needs during the COVID-19 pandemic through the perception of their caregivers in the Northeast of Brazil. Methods: Qualitative descriptive-exploratory research carried out between June and September 2020, in a municipality in the Northeast of Brazil. Eleven caregivers participated through semi-structured interviews conducted at home. The data were submitted to thematic content analysis. Results: The social isolation period and the suspension of health services affected the continuity of care, configuring the category “Implications of the COVID-19 pandemic for the continuity of care”. Caregivers expressed fear of children contracting the coronavirus, characterizing the category “Fears and uncertainties of the COVID-19 pandemic in view of the vulnerability of children with special healthcare needs”. Final considerations: Caregivers’ reports revealed problems in the continuity of care for the studied cohort. Therefore, health care practices must be rethought in times of pandemic.


2020 ◽  
Vol 5 (5) ◽  
pp. 598-603
Author(s):  
Vera Vladimirovna Monzhievskaya ◽  
Mikhail Sergeevich Ruzhnikov

The article aims to identify the areas of psychological and pedagogical counselling for secondary school pupils during the self-isolation period...


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