Opioid treatment for non-cancer pain: we need a comprehensive approach

BMJ ◽  
2021 ◽  
pp. n3045
Author(s):  
Patrice Forget
Keyword(s):  
Cancer Pain ◽  
Comprehensive Approach ◽  
Opioid Treatment

Evaluation of the side effects related to long term opioid treatment in cancer pain children

Pain ◽  
1990 ◽  
Vol 41 ◽  
pp. S8 ◽  
Author(s):  
E. Pichard-Leandri ◽  
Ph. Poulain ◽  
A. Gauvain-Piquard
Keyword(s):  
Side Effects ◽  
Cancer Pain ◽  
Opioid Treatment

scholarly journals Factors associated with the development of depression in chronic non-cancer pain patients following the onset of opioid treatment for pain

2015 ◽  
Vol 184 ◽  
pp. 72-80 ◽  
Author(s):  
Kimberley Smith ◽  
Richard P. Mattick ◽  
Raimondo Bruno ◽  
Suzanne Nielsen ◽  
Milton Cohen ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Opioid Treatment ◽  
Factors Associated ◽  
Pain Patients

Systematic review of the role of alternative application routes for opioid treatment for moderate to severe cancer pain: An EPCRC opioid guidelines project

2011 ◽  
Vol 25 (5) ◽  
pp. 578-596 ◽  
Author(s):  
Lukas Radbruch ◽  
Peter Trottenberg ◽  
Frank Elsner ◽  
Stein Kaasa ◽  
Augusto Caraceni
Keyword(s):  
Systematic Review ◽  
Cancer Pain ◽  
Opioid Treatment

scholarly journals Random vs Targeted Urine Drug Testing Among Patients Undergoing Long-term Opioid Treatment for Cancer Pain

JAMA Oncology ◽  
2020 ◽  
Vol 6 (4) ◽  
pp. 580 ◽  
Author(s):  
Joseph Arthur ◽  
Zhanni Lu ◽  
Kristy Nguyen ◽  
David Hui ◽  
Bernard Prado ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Drug Testing ◽  
Opioid Treatment ◽  
Urine Drug Testing ◽  
Urine Drug

The effects of long‐term opioid treatment on the immune system in chronic non‐cancer pain patients: A systematic review

2019 ◽  
Vol 24 (3) ◽  
pp. 481-496 ◽  
Author(s):  
Pernille D. K. Diasso ◽  
Hanne Birke ◽  
Susanne D. Nielsen ◽  
Katharina M. Main ◽  
Jette Højsted ◽  
...  
Keyword(s):  
Systematic Review ◽  
Immune System ◽  
Cancer Pain ◽  
Opioid Treatment ◽  
Pain Patients

Patient reported outcomes and neuropsychological testing in patients with chronic non-cancer pain in long-term opioid therapy: a pilot study

2019 ◽  
Vol 19 (3) ◽  
pp. 533-543 ◽  
Author(s):  
Pernille D. K. Diasso ◽  
Per Sjøgren ◽  
Jette Højsted ◽  
Susanne D. Nielsen ◽  
Katharina M. Main ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Reaction Time ◽  
Pilot Study ◽  
Cancer Pain ◽  
Opioid Consumption ◽  
Opioid Treatment ◽  
Continuous Reaction ◽  
Continuous Reaction Time

Abstract Background and aims Opioid consumption has increased dramatically in patients with chronic non-cancer pain (CNCP), but long-term consequences are still unclear. The aim of this study is to investigate the effects of long-term opioid treatment on pain, cognition, mood, sleep and quality of life in CNCP patients. Methods In this cross-sectional pilot study, two groups of patients with CNCP treated in a multidisciplinary pain center were selected: (1) opioid group: ≥30 mg morphine equivalent/day for >4 weeks, and (2) control group: no opioid consumption for >4 weeks. Socio-demographic data, alcohol consumption, smoking habits and body mass index (BMI) were registered and pain (brief pain inventory), mood (Hospital Anxiety and Depression Scale), sleep (Pittsburgh Sleep Quality Index) and quality of life (RAND 36-Item Health Survey) were assessed. Continuous Reaction Time and the Digit Span Test were used to evaluate cognitive function. Data was analyzed with a Fisher’s exact test and Wilcoxon two-sample test. Results Forty-two patients with CNCP were included (21 in each group). No differences regarding socio-demographics, smoking/alcohol habits and duration, type, or intensity of pain were found. More patients in the opioid group had significantly higher BMI (62% above BMI 25 vs. 33.3%, p = 0.042). Consequently, the subsequent data analyses were controlled for BMI. The two groups did not differ in pain, cognition, anxiety, depression, sleep or quality of life but both showed lower values than the normal standards. Further, the opioid group presented a tendency to lower ratings regarding pain and social function and performed below the normal cut off in the continuous reaction time. Conclusions No significant differences between the two groups were found regarding any of the above-mentioned variables. Interestingly, the patients assessed, regardless of taking opioids or not, could be classified with moderate pain intensity, anxiety and low quality of sleep and life compared to norm standards. Implications The findings of this pilot study suggested that long-term opioid treatment may influence pain and quality of life among CNCP patients. A larger cohort is needed to verify these findings.

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