Lindsay Symon: neurosurgery professor and distinguished surgeon whose research into the ischaemic penumbra improved stroke treatment

BMJ ◽  
2020 ◽  
pp. m319
Author(s):  
Penny Warren
Keyword(s):  
Stroke Treatment ◽  
Ischaemic Penumbra

Imaging May Widen Stroke Treatment Window

2009 ◽  
Vol 2 (11) ◽  
pp. 9
Author(s):  
AMY ROTHMAN SCHONFELD
Keyword(s):  
Stroke Treatment ◽  
Treatment Window

Sestrins: A New Kid for Stroke Treatment?

2017 ◽  
Vol 14 (6) ◽  
Author(s):  
Xudan Shi ◽  
Liang Xu ◽  
Jay Malagult ◽  
Jiping Tang ◽  
Min Yan ◽  
...  
Keyword(s):  
Stroke Treatment

Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke

2018 ◽  
Vol 17 (5) ◽  
pp. 338-347 ◽  
Author(s):  
Shan Wang ◽  
Fei Ma ◽  
Longjian Huang ◽  
Yong Zhang ◽  
Yuchen Peng ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Complex Disease ◽  
Time Window ◽  
Recombinant Tissue Plasminogen Activator ◽  
Research Progress ◽  
Apium Graveolens ◽  
Synthetic Compound ◽  
Stroke Treatment ◽  
Single Target ◽  
Anti Oxidant

Background and Objective: Stroke is a leading cause of morbidity and mortality in both developed and developing countries all over the world. The only drug for ischemic stroke approved by FDA is recombinant tissue plasminogen activator (rtPA). However, only 2-5% stroke patients receive rtPAs treatment due to its strict therapeutic time window. As ischemic stroke is a complex disease involving multiple mechanisms, medications with multi-targets may be more powerful compared with single-target drugs. Dl-3-n-Butylphthalide (NBP) is a synthetic compound based on l-3-n- Butylphthalide that is isolated from seeds of Apium graveolens. The racemic 3-n-butylphthalide (dl- NBP) was approved by Food and Drug Administration of China for the treatment of ischemic stroke in 2002. A number of clinical studies indicated that NBP not only improved the symptoms of ischemic stroke, but also contributed to the long-term recovery. The potential mechanisms of NBP for ischemic stroke treatment may target different pathophysiological processes, including anti-oxidant, antiinflammation, anti-apoptosis, anti-thrombosis, and protection of mitochondria et al. Conclusion: In this review, we have summarized the research progress of NBP for the treatment of ischemic stroke during the past two decades.

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