Prenatal vitamins in early pregnancy may lower risk of autism in high risk families

BMJ ◽  
2019 ◽  
pp. l916 ◽  
Author(s):  
Susan Mayor
Keyword(s):  
High Risk ◽  
Early Pregnancy ◽  
Lower Risk ◽  
Prenatal Vitamins ◽  
High Risk Families

Effectiveness of reverse cascade screening for familial hypercholesteroleamia in very high risk families in China

2017 ◽  
Vol 263 ◽  
pp. e235-e236
Author(s):  
Xue Wu ◽  
Jing Pang ◽  
Jie Peng ◽  
Yan Chen ◽  
Jing Hong ◽  
...  
Keyword(s):  
High Risk ◽  
Cascade Screening ◽  
Very High ◽  
High Risk Families

scholarly journals Variants in the Signaling Protein TSAd are Associated with Susceptibility to Ovarian Cancer in BRCA1/2 Negative High Risk Families

2012 ◽  
Vol 7 ◽  
pp. BMI.S10815 ◽  
Author(s):  
Ludmila Kaplun ◽  
Aviva Levine Fridman ◽  
Wei Chen ◽  
Nancy K. Levin ◽  
Sidra Ahsan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
High Risk ◽  
Cancer Risk ◽  
Allelic Variation ◽  
High Risk Population ◽  
Ovarian Cancer Risk ◽  
Familial Ovarian Cancer ◽  
Cell Growth And Differentiation ◽  
Brca1 Brca2 ◽  
High Risk Families

A substantial fraction of familial ovarian cancer cases cannot be attributed to specific genetic factors. The discovery of additional susceptibility genes will permit a more accurate assessment of hereditary cancer risk and allow for monitoring of predisposed women in order to intervene at the earliest possible stage. We focused on a population with elevated familial breast and ovarian cancer risk. In this study, we identified a SNP rs926103 whose minor allele is associated with predisposition to ovarian but not breast cancer in a Caucasian high-risk population without BRCA1/ BRCA2 mutations. We have found that the allelic variation of rs926103, which alters amino acid 52 of the encoded protein SH2D2A/TSAd, results in differences in the activity of this protein involved in multiple signal transduction pathways, including regulation of immune response, tumor vascularization, cell growth, and differentiation. Our observation provides a novel candidate genetic biomarker of elevated ovarian cancer risk in members of high-risk families without BRCA1/2 mutations, as well as a potential therapeutic target, TSAd.

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