Studies on non-alcoholic fatty liver disease should stratify by disease severity

BMJ ◽  
2019 ◽  
pp. l6495 ◽  
Author(s):  
Matthew T McKenna-Barry ◽  
John D Ryan
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Vitamin D levels are not associated with non-alcoholic fatty liver disease severity in a Brazilian population

2020 ◽  
pp. 1-8
Author(s):  
Jeniffer Danielle M. Dutra ◽  
Quelson Coelho Lisboa ◽  
Silvia Marinho Ferolla ◽  
Carolina Martinelli M. L. Carvalho ◽  
Camila Costa M. Mendes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Fatty Liver ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Hypovitaminosis D ◽  
Alcoholic Fatty Liver ◽  
Vitamin D Levels ◽  
The Mean ◽  
Alcoholic Fatty Liver Disease

Abstract. Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histological parameters of 139 NAFLD patients were evaluated according to two different cut-off points of serum 25-hydroxyvitamin D levels (20 ng/mL and 30 ng/mL). The mean age of the population was 56 ± 16 years, most patients were female (83%), 72% had hypertension, 88% dyslipidemia, 46% DM, 98% central obesity, and 82% metabolic syndrome. Serum vitamin D levels were < 30 ng/mL in 78% of the patients, and < 20 ng/mL in 35%. The mean vitamin D level was 24.3 ± 6.8 ng/mL. The comparison between the clinical, biochemical and histological characteristics of the patients according to the levels of vitamin D showed no significant difference. Most patients with NAFLD had hypovitaminosis D, but low vitamin D levels were not related to disease severity and the presence of comorbidities.

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

2013 ◽  
Vol 58 (1) ◽  
pp. 119-125 ◽  
Author(s):  
Rui E. Castro ◽  
Duarte M.S. Ferreira ◽  
Marta B. Afonso ◽  
Pedro M. Borralho ◽  
Mariana V. Machado ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Ursodeoxycholic Acid ◽  
Disease Severity ◽  
Rat Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Non-alcoholic Fatty Liver Disease and ECG changes in Egyptian Patients

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A S Alsawaby ◽  
R A Elfeky ◽  
A E Mohamed ◽  
H Abdelaziz ◽  
S A Saleh ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Clinical Laboratory ◽  
Qtc Interval ◽  
Liver Size ◽  
Alcoholic Fatty Liver ◽  
Size Grade ◽  
Alcoholic Fatty Liver Disease

Abstract Background interactions between the heart and the liver have been described. The presence and severity of non-alcoholic fatty liver disease (NAFLD) was found to be associated with increased QTc interval and subclinical cardiac abnormalities. Aim of the work is to evaluate the electrocardiographic (ECG) and echocardiographic changes in patients with NAFLD and its correlation with disease severity. Patients and Methods this study was conducted on 50 NAFLD patients and 50 controls. Clinical, laboratory, ultrasonographic examinations were done for all included subjects together with liver biopsies. ECG and ECHO were also performed. Results longer corrected QT was found in the NAFLD group in comparison to controls (406.6±26.8 msec and 380.0±24.5 msec respectively). Significant correlation between QTc and liver size, grade of steatosis and NAFLD activity score (NAS) was found. 16% and 8% of NAFLD patients had diastolic and valvular dysfunctions respectively. Conclusion NAFLD is associated with significant QTc prolongation and structural heart changes with significant correlation between QTc and disease severity.

scholarly journals Whole-body substrate metabolism is associated with disease severity in patients with non-alcoholic fatty liver disease

Gut ◽  
2012 ◽  
Vol 62 (11) ◽  
pp. 1625-1633 ◽  
Author(s):  
Ilaria Croci ◽  
Nuala M Byrne ◽  
Stéphane Choquette ◽  
Andrew P Hills ◽  
Veronique S Chachay ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Whole Body ◽  
Alcoholic Fatty Liver ◽  
Substrate Metabolism ◽  
Alcoholic Fatty Liver Disease

Mo1016 Role of Oxidative Stress and Insulin Resistance in the Disease Severity of Non-Alcoholic Fatty Liver Disease

2013 ◽  
Vol 144 (5) ◽  
pp. S-1013
Author(s):  
Billur Canbakan ◽  
Hakan Senturk ◽  
Murat Tuncer ◽  
Ibrahim Hatemi ◽  
Emine Koroglu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Multiparametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease severity

2017 ◽  
Vol 37 (7) ◽  
pp. 1065-1073 ◽  
Author(s):  
Michael Pavlides ◽  
Rajarshi Banerjee ◽  
Elizabeth M. Tunnicliffe ◽  
Catherine Kelly ◽  
Jane Collier ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Liver Disease ◽  
Magnetic Resonance ◽  
Fatty Liver ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Resonance Imaging ◽  
Alcoholic Fatty Liver ◽  
Multiparametric Magnetic Resonance Imaging ◽  
Alcoholic Fatty Liver Disease

scholarly journals Causes of Mortality in Non-Alcoholic Fatty Liver Disease (NAFLD) and Alcohol Related Fatty Liver Disease (AFLD)

2020 ◽  
Vol 26 (10) ◽  
pp. 1079-1092 ◽  
Author(s):  
Michael P. Johnston ◽  
Janisha Patel ◽  
Christopher D. Byrne
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Alcohol Consumption ◽  
Fatty Liver ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Decompensated Cirrhosis ◽  
Alcoholic Fatty Liver ◽  
Increased Risk ◽  
Alcoholic Fatty Liver Disease

: Non-alcoholic fatty liver disease (NAFLD) and alcohol related fatty liver disease (AFLD) both represent a spectrum of liver disease severity from hepatic steatosis to fibrosis and cirrhosis. Both NAFLD and AFLD are common diseases in the general population. NAFLD affects ~25% of the adult global population whilst AFLD has become the commonest indication for liver transplantation in the United States. It is often not possible to distinguish between NAFLD and AFLD on examination of liver histology, consequently, differentiation between NAFLD and AFLD is heavily reliant on a history of alcohol consumption. : Age, smoking, alcohol consumption and sex appear to influence the risk of mortality in NAFLD or AFLD. In NAFLD and AFLD, the key causes of increased liver-related mortality are advanced liver fibrosis and cirrhosis leading to complications such as hepatocellular carcinoma and decompensated cirrhosis. NAFLD and AFLD are also associated with an increased risk of all-cause mortality including an increased risk of extra-hepatic malignancy. Non-invasive biomarkers of liver disease severity in NAFLD and AFLD perform poorly to predict mortality. However, alanine aminotransferase, gamma-glutamyl transpeptidase, FIB-4 and the NAFLD Fibrosis Score are independently associated with increased mortality in NAFLD. : Both NAFLD and AFLD are associated with extra-hepatic risk factors and complications such as metabolic syndrome encompassing obesity, hypertension, type 2 diabetes mellitus, and chronic kidney disease. AFLD is associated with hypertension and cardiovascular disease as well as other organ damage. : This narrative review discusses the associations, risk factors and diagnostic biomarkers linking NAFLD and AFLD with increased mortality.

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