scholarly journals Serial circulating omega 3 polyunsaturated fatty acids and healthy ageing among older adults in the Cardiovascular Health Study: prospective cohort study

BMJ ◽  
2018 ◽  
pp. k4067 ◽  
Author(s):  
Heidi TM Lai ◽  
Marcia C de Oliveira Otto ◽  
Rozenn N Lemaitre ◽  
Barbara McKnight ◽  
Xiaoling Song ◽  
...  
Keyword(s):  
Older Adults ◽  
Docosahexaenoic Acid ◽  
Eicosapentaenoic Acid ◽  
Linolenic Acid ◽  
Cardiovascular Health ◽  
Docosapentaenoic Acid ◽  
Healthy Ageing ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Omega 3

AbstractObjectiveTo determine the longitudinal association between serial biomarker measures of circulating omega 3 polyunsaturated fatty acid (n3-PUFA) levels and healthy ageing.DesignProspective cohort study.SettingFour communities in the United States (Cardiovascular Health Study) from 1992 to 2015.Participants2622 adults with a mean (SD) age of 74.4 (4.8) and with successful healthy ageing at baseline in 1992-93.ExposureCumulative levels of plasma phospholipid n3-PUFAs were measured using gas chromatography in 1992-93, 1998-99, and 2005-06, expressed as percentage of total fatty acids, including α-linolenic acid from plants and eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid from seafoood.Main outcome measureHealthy ageing defined as survival without chronic diseases (ie, cardiovascular disease, cancer, lung disease, and severe chronic kidney disease), the absence of cognitive and physical dysfunction, or death from other causes not part of the healthy ageing outcome after age 65. Events were centrally adjudicated or determined from medical records and diagnostic tests.ResultsHigher levels of long chain n3-PUFAs were associated with an 18% lower risk (95% confidence interval 7% to 28%) of unhealthy ageing per interquintile range after multivariable adjustments with time-varying exposure and covariates. Individually, higher eicosapentaenoic acid and docosapentaenoic acid (but not docosahexaenoic acid) levels were associated with a lower risk: 15% (6% to 23%) and 16% (6% to 25%), respectively. α-linolenic acid from plants was not noticeably associated with unhealthy ageing (hazard ratio 0.92, 95% confidence interval 0.83 to 1.02).ConclusionsIn older adults, a higher cumulative level of serially measured circulating n3-PUFAs from seafood (eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid), eicosapentaenoic acid, and docosapentaenoic acid (but not docosahexaenoic acid from seafood or α-linolenic acid from plants) was associated with a higher likelihood of healthy ageing. These findings support guidelines for increased dietary consumption of n3-PUFAs in older adults.

scholarly journals Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study

2012 ◽  
Vol 96 (2) ◽  
pp. 269-274 ◽  
Author(s):  
Rozenn N Lemaitre ◽  
Colleen Sitlani ◽  
Xiaoling Song ◽  
Irena B King ◽  
Barbara McKnight ◽  
...  
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Congestive Heart Failure ◽  
Linolenic Acid ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study

scholarly journals Plasma phospholipid and dietary α-linolenic acid, mortality, CHD and stroke: the Cardiovascular Health Study

2014 ◽  
Vol 112 (7) ◽  
pp. 1206-1213 ◽  
Author(s):  
Amanda M. Fretts ◽  
Dariush Mozaffarian ◽  
David S. Siscovick ◽  
Colleen Sitlani ◽  
Bruce M. Psaty ◽  
...  
Keyword(s):  
Older Adults ◽  
Linolenic Acid ◽  
Cardiovascular Mortality ◽  
Lower Risk ◽  
Cardiovascular Health ◽  
Plasma Phospholipid ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Risk Of Mortality ◽  
Long Chain

Previous studies have suggested that long-chain n-3 fatty acids derived from seafood are associated with a lower risk of mortality, CHD and stroke. Whether α-linolenic acid (ALA, 18 : 3n-3), a plant-derived long-chain essential n-3 fatty acid, is associated with a lower risk of these outcomes is unclear. The aim of the present study was to examine the associations of plasma phospholipid and dietary ALA with the risk of mortality, CHD and stroke among older adults who participated in the Cardiovascular Health Study, a cohort study of adults aged ≥ 65 years. A total of 2709 participants were included in the plasma phospholipid ALA analysis and 2583 participants were included in the dietary ALA analysis. Cox regression was used to assess the associations of plasma phospholipid and dietary ALA with the risk of mortality, incident CHD and stroke. In minimally and multivariable-adjusted models, plasma phospholipid ALA was found to be not associated with the risk of mortality, incident CHD or stroke. After adjustment for age, sex, race, enrolment site, education, smoking status, diabetes, BMI, alcohol consumption, treated hypertension and total energy intake, higher dietary ALA intake was found to be associated with a lower risk of total and non-cardiovascular mortality; on comparing the highest quintiles of dietary ALA with the lowest quintiles, the HR for total mortality and non-cardiovascular mortality were found to be 0·73 (95 % CI 0·61, 0·88) and 0·64 (95 % CI 0·52, 0·80), respectively. Dietary ALA was found to be not associated with the risk of cardiovascular mortality, incident CHD or stroke. In conclusion, the results of the present suggest study that dietary ALA, but not plasma phospholipid ALA, is associated with a lower risk of total and non-cardiovascular mortality in older adults.

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