scholarly journals Preoperative physiotherapy for the prevention of respiratory complications after upper abdominal surgery: pragmatic, double blinded, multicentre randomised controlled trial

BMJ ◽  
2018 ◽  
pp. j5916 ◽  
Author(s):  
Ianthe Boden ◽  
Elizabeth H Skinner ◽  
Laura Browning ◽  
Julie Reeve ◽  
Lesley Anderson ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Abdominal Surgery ◽  
Controlled Trial ◽  
Respiratory Complications ◽  
Upper Abdominal Surgery ◽  
Upper Abdominal ◽  
Randomised Controlled ◽  
Double Blinded

Eine einmalige Atemphysiotherapie vor geplanten Oberbauchoperationen vermindert postoperative respiratorische Komplikationen

2018 ◽  
Vol 28 (02) ◽  
pp. 71-71
Keyword(s):  
Randomised Controlled Trial ◽  
Abdominal Surgery ◽  
Controlled Trial ◽  
Respiratory Complications ◽  
Upper Abdominal Surgery ◽  
Upper Abdominal ◽  
Randomised Controlled ◽  
Double Blinded

Referat zur Arbeit von Boden I, Skinner EH, Browning L, Reeve J, Anderson L, Hill C, Robertson IK, Story D, Denehy L. Preoperative physiotherapy for the prevention of respiratory complications after upper abdominal surgery: pragmatic, double blinded, multicentre randomised controlled trial. BMJ 2018; 360: j5916In einer multizentrischen randomisierten, Placebo-kontrollierten Studie an 441 Patienten wurde nachgewiesen, dass eine einmalige Atemphysiotherapie vor geplanten Oberbauchoperationen die Zahl von postoperativen respiratorischen Komplikationen drastisch verringern kann. Die Untersuchung wurde an Universitätskrankenhäusern in Australien und Neuseeland im Doppelblind-Design durchgeführt.

scholarly journals Correction for vol. 365, p.

BMJ ◽  
2019 ◽  
pp. l1862
Keyword(s):  
Randomised Controlled Trial ◽  
Abdominal Surgery ◽  
Controlled Trial ◽  
Respiratory Complications ◽  
Upper Abdominal Surgery ◽  
Upper Abdominal ◽  
Randomised Controlled ◽  
Double Blinded

Preoperative physiotherapy for the prevention of respiratory complications after upper abdominal surgery: pragmatic, double blinded, multicentre randomised controlled trial

scholarly journals Mechanical bowel preparation and oral antibiotics versus mechanical bowel preparation only prior rectal surgery (MOBILE2): a multicentre, double-blinded, randomised controlled trial—study protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e051269
Author(s):  
Laura Koskenvuo ◽  
Pipsa Lunkka ◽  
Pirita Varpe ◽  
Marja Hyöty ◽  
Reetta Satokari ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Bowel Preparation ◽  
Controlled Trial ◽  
Rectal Surgery ◽  
Mechanical Bowel Preparation ◽  
Oral Antibiotic ◽  
Oral Antibiotics ◽  
Number Of Patients ◽  
Randomised Controlled ◽  
Double Blinded

IntroductionMechanical bowel preparation (MBP) prior to rectal surgery is widely used. Based on retrospective data many guidelines recommend mechanical and oral antibiotic bowel preparation (MOABP) to reduce postoperative complications and specifically surgical site infections (SSIs). The primary aim of this study is to examine whether MOABP reduces complications of rectal surgery.Methods and analysisThe MOBILE2 (Mechanical Bowel Preparation and Oral Antibiotics vs Mechanical Bowel Preparation Only Prior Rectal Surgery) trial is a multicentre, double-blinded, parallel group, superiority, randomised controlled trial comparing MOABP to MBP among patients scheduled for rectal surgery with colorectal or coloanal anastomosis. The patients randomised to the MOABP group receive 1 g neomycin and 1 g metronidazole two times on a day prior to surgery and patients randomised to the MBP group receive identical placebo. Based on power calculations, 604 patients will be enrolled in the study. The primary outcome is Comprehensive Complication Index within 30 days after surgery. Secondary outcomes are SSIs within 30 days after surgery, the number and classification of anastomosis dehiscences, the length of hospital stay, mortality within 90 days after surgery and the number of patients who received adjuvant treatment if needed. Tertiary outcomes are overall survival, disease-specific survival, recurrence-free survival and difference in quality-of-life before and 1 year after surgery. In addition, the microbiota differences in colon mucosa are analysed.Ethics and disseminationThe Ethics Committee of Helsinki University Hospital approved the study. The findings will be disseminated in peer-reviewed academic journals.Trial registration numberNCT04281667.

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