scholarly journals Risk of invasive cervical cancer after atypical glandular cells in cervical screening: nationwide cohort study

BMJ ◽  
2016 ◽  
pp. i276 ◽  
Author(s):  
Jiangrong Wang ◽  
Bengt Andrae ◽  
Karin Sundström ◽  
Peter Ström ◽  
Alexander Ploner ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cohort Study ◽  
Cervical Screening ◽  
Invasive Cervical Cancer ◽  
Glandular Cells ◽  
Atypical Glandular Cells

scholarly journals Cervical Lesion: Types and Etiology

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Fasogbon Samuel Ayobami
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Cervical Screening ◽  
Cervical Lesion ◽  
Early Age ◽  
Related Factors ◽  
Squamous Cells ◽  
Multiple Sex Partners ◽  
Glandular Cells ◽  
Atypical Glandular Cells

A cervical lesion is an area of abnormal tissue found on the cervix, which is the lower end of a woman’s uterus. The type of the lesion can be atypical squamous cells, squamous intraepithelianeoplasia, and atypical glandular cells. The early stages of cervical cancer may be asymptomatic. In advanced disease, there may be metastases to the abdomen, lungs or any other organ. Infection with some types of human papilloma virus (HPV) is the highest risk factor for cervical cancer which can be transmitted due to multiple sex partners, followed by smoking. Other risk factors include human immunodeficiency virus (HIV), early age at first sexual intercourse, early age at first pregnancy, tobacco use, exposure to passive smoke and other related factors. It is therefore recommended that all the risk factors should be avoided to reduce cervical cancer in the society and women should go for regular cervical screening as early detection can easily be treated.

scholarly journals More focus on atypical glandular cells in cervical screening: Risk of significant abnormalities and low histological follow-up rate

CytoJournal ◽  
2020 ◽  
Vol 17 ◽  
pp. 22
Author(s):  
Pingping Zhong ◽  
Chenghong Yin ◽  
Yulan Jin ◽  
Tianbao Chen ◽  
Yang Zhan ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Cervical Screening ◽  
Close Relation ◽  
Prior History ◽  
Pap Smears ◽  
Chi Square ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Chi Square Test

Objectives: Atypical glandular cells (AGC) detected by Papanicolaou (Pap) smears are in close relation with adenocarcinoma and precursors detected by histopathology. Yet, sometimes the cytological diagnosis of AGC has been neglected. With increase of adenocarcinoma and precursors, we need more focus on glandular abnormalities. Material and Methods: Clinicopathological data of patients who had AGC on Pap smears between April 2015 and October 2018 and underwent histological follow-up were retrieved from the computerized database of Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Patients with a prior history of cancer were excluded from the study. Statistical analyses were performed using Pearson’s Chi-square test in SPSS software version 23. P < 0.05 (two sided) was considered as statistical significance. Results: Liquid-based cytological examination of the uterine cervix was carried out in 164,080 women. Five hundred and twenty-five women were diagnosed with AGC, 314 with not otherwise specified (AGC-NOS), and 211 with favor neoplastic (AGC-FN). Only 310 cases had histological follow-up, 168 women (168/314, 53.5%) originally with AGC-NOS on Pap smears, and 142 (142/211, 67.3%) with AGC-FN. The median age of histological significant abnormalities was 46.7 years, and 126 women (126/162, 77.8%) were postmenopausal. Sixty-six cases (66/168, 39.3%) of AGC-NOS had significant abnormalities (96/142, 67.6%, AGC-FN). One hundred and sixty-two cases of significant abnormalities included 40 high-grade squamous abnormalities and 122 glandular abnormalities. AGC-FN was more likely to be associated with a clinically significant abnormalities (P < 0.001) compared to AGC-NOS. Conclusions: Patients with AGC on Pap smears are in close relation with significant abnormalities, especially with significant glandular abnormalities on histopathology slices. AGC should be evaluated vigilantly with histological workup, especially if patients are diagnosed with AGC-FN and are aged 41–60 years. We need more focus on AGC.

Cervical neoplasia

2019 ◽  
pp. 357-364
Keyword(s):  
Cervical Cancer ◽  
Screening Program ◽  
Cervical Screening ◽  
Hpv Vaccination ◽  
Invasive Cervical Cancer ◽  
Intraepithelial Neoplasia ◽  
Cervical Neoplasia ◽  
Women Living With Hiv ◽  
The Bethesda System ◽  
Common Malignancy

Cervical neoplasia provides an overview of the 4th most common malignancy in women worldwide, including the premalignant phase. Specific terminology used in cytology and histology (including atypia, dyskaryosis, cervical intraepithelial neoplasia (CIN), cervical glandular intraepithelial neoplasia (CGIN) and invasive cervical cancer (ICC) are explained, and the epidemiology and risk factors (with an emphasis on human papilloma virus (HPV)) for this common malignancy are included. Clinical presentation is outlined. Cervical screening is discussed, including the role of HPV testing, and both the British Association for Cytopathology/NHS cervical screening program 2013 classification of cervical cytology and the Bethesda system (used more widely worldwide) are explained. Diagnosis includes colposcopic examination of the cervix, and the management of both CIN and cervical cancer are included. HPV vaccination, pregnancy, and women living with HIV (including ICC as AIDS-defining) are discussed.

scholarly journals Clinical Features of Women Diagnosed With Invasive Cervical Cancer in Ghana

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 40s-40s
Author(s):  
Y. Nartey ◽  
P. Hill ◽  
K. Amo-Antwi ◽  
K. Nyarko ◽  
J. Yarney ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Clinical Features ◽  
Teaching Hospital ◽  
Cervical Screening ◽  
Invasive Cervical Cancer ◽  
Figo Stage ◽  
Middle Income ◽  
Increased Risk ◽  
Referral Hospitals

Background: The incidence of cervical cancer continues to increase in many low- and middle-income countries. It remains the commonest cancer affecting females in Ghana. However, comprehensive information on the clinical characteristics of women diagnosed with invasive cervical cancer is scarce. Aim: To characterize the clinical features of women with invasive cervical cancer in Ghana. Methods: We conducted a retrospective study in two large referral hospitals in Ghana: the Korle Bu teaching hospital, Accra and Komfo Anokye teaching hospital, Kumasi. Through the review of paper-based, electronic, and pathology medical records, information on women diagnosed with invasive cervical cancer from 1st January 2010 to 31st December 2013 was collected. The information was entered onto a standardized data abstraction sheet and included demographics, comorbid conditions, treatment and follow-up. All analyses were conducted in STATA and described the distribution of key clinical features by the stage at diagnosis. Results: A total of 1,725 women with invasive cervical cancer were included in the analysis. Few had cervical screening before their cervical cancer diagnosis (1.1%). Women who were resident in a metropolitan area ( P = 0.034), or who had any comorbidity ( P < 0.001) were at an increased risk of FIGO stage III-IV disease. The majority of women had at least two diagnostic investigations (75%) with cervical biopsy performed for 95.5% of women. More than half received radiotherapy (55.4%) and only 22.4% receiving chemotherapy. Clinical follow-up after the first consultation was performed for 61%, with 73% of women with clinical follow-up having at least one follow-up investigation. Conclusion: Improvements in access to early diagnosis and optimal treatment of cervical cancer, such as an increased use of chemoradiation would reduce the burden of the disease in Ghana.

Risk of Gynecologic Cancer after Atypical Glandular Cells Found on Cervical Cytology: A Population-Based Cohort Study

2021 ◽  
Vol 30 (4) ◽  
pp. 743-750
Author(s):  
Clare A. Aitken ◽  
Erik E.L. Jansen ◽  
Albert G. Siebers ◽  
Anne-Marie L.D. van Haaften-de Jong ◽  
Folkert J. van Kemenade ◽  
...  
Keyword(s):  
Cohort Study ◽  
Gynecologic Cancer ◽  
Population Based ◽  
Cervical Cytology ◽  
Glandular Cells ◽  
Atypical Glandular Cells

A cytohistologic study of atypical glandular cells detected in cervical smears during cervical screening tests in Iran

2006 ◽  
Vol 16 (1) ◽  
pp. 257-261 ◽  
Author(s):  
N. IZADI MOOD ◽  
Z. EFTEKHAR ◽  
A. HARATIAN ◽  
L. SAEEDI ◽  
P. RAHIMI-MOGHADDAM ◽  
...  
Keyword(s):  
Cervical Screening ◽  
Screening Tests ◽  
Cervical Smears ◽  
Glandular Cells ◽  
Atypical Glandular Cells

Advances in cervical cancer screening and human papillomavirus vaccines

2006 ◽  
Vol 12 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Cynthia Feeley
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cervical Screening ◽  
Invasive Cervical Cancer ◽  
Hpv Testing ◽  
Industrialized Countries ◽  
Major Health Problem ◽  
Major Health ◽  
Efficiency And Effectiveness ◽  
Overall Efficiency

Cervical cancer is causally linked to human papillomavirus (HPV) and constitutes a major health problem for women. Nearly 80% of the 510,000 cases reported worldwide each year occur in developing countries which lack organized screening programmes. Cervical screening has effectively reduced the incidence of and mortality from invasive cervical cancer in industrialized countries, but is not completely protective. Cervical screening is now undergoing modernization and has seen several changes in recent years. These aim to enhance the overall efficiency and effectiveness of screening, reduce rates of inadequate sampling, increase sensitivity rates and facilitate ancillary technologies, such as HPV testing. This review discusses these advances and the development of HPV vaccines.

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