Metformin is backed as first line therapy for type 2 diabetes

BMJ ◽  
2016 ◽  
pp. i2236 ◽  
Author(s):  
Jacqui Wise
Keyword(s):  
Type 2 Diabetes ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

Insulin as a First-Line Therapy in Type 2 Diabetes: Should the use of sulfonylureas be halted?

Diabetes Care ◽  
2008 ◽  
Vol 31 (Supplement 2) ◽  
pp. S136-S139 ◽  
Author(s):  
E. Standl ◽  
O. Schnell
Keyword(s):  
Type 2 Diabetes ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

Rationale and design of a clinical trial to evaluate metformin and colesevelam HCl as first-line therapy in type 2 diabetes and colesevelam HCl in prediabetes

2009 ◽  
Vol 25 (9) ◽  
pp. 2239-2249 ◽  
Author(s):  
Michael R. Jones ◽  
Sunder Mudaliar ◽  
Eric Hernandez-Triana ◽  
Ambika G. Unnikrishnan ◽  
Yu-Ling Lai ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

scholarly journals Characteristics and treatment patterns of patients with type 2 diabetes in Lebanon: the DISCOVER study

2021 ◽  
Vol 27 (5) ◽  
pp. 509-515
Author(s):  
Sami T. Azar ◽  
Akram Echtay ◽  
Mireille Amm ◽  
Hajar Ballout ◽  
Iskandar Cheaib ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Practice ◽  
Glycaemic Control ◽  
Treatment Patterns ◽  
Second Line ◽  
First Line ◽  
Second Line Therapy ◽  
First Line Therapy ◽  
Line Therapy

Background: Lebanon is part of the global DISCOVER study, a global, noninterventional, multicentre, prospective study with 3-years of follow-up. Aims: The aim of this study is to describe real-world clinical practice in terms of type 2 diabetes mellitus (T2DM) disease management and treatment patterns within Lebanon. Methods: Baseline demographic and clinical parameters were captured on a standardized case report form, according to routine clinical practice at each clinical site. Results: We recruited 348 patients. At the initiation of second-line therapy, mean duration of diabetes was 6.7 [standard deviation (SD) 6.5] years; mean HbA1c and fasting plasma glucose levels were 8.5% (SD 1.6%) and 178.7 (SD 56.5) mg/dL respectively. Almost half the patients were hypertensive (45.1%) or had dyslipidaemia (48.6%). Metformin monotherapy was used as first-line therapy in 56.9% of the patients and upfront dual therapy in 25%. The primary reason for changing first-line therapy was poor glycaemic control. The main factors in choosing the second-line therapy were efficacy, tolerability and hypoglycaemia. Conclusion: Clinical inertia was evident in this cohort of patients as they had suboptimal glycaemic control at the time of enrolment and the initiation of second-line therapy. Treatment intensification is required to reduce diabetes-related adverse outcomes.

An Evaluation for Diabetic patient by measuring FDCs

2020 ◽  
Vol 5 (2) ◽  
pp. 22-25
Author(s):  
Vurimi Chaitanya Sai Manikanta
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Single Dose ◽  
Fixed Dose ◽  
Indian Market ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

Type 2 diabetes mellitus (T2DM) is an enlightened diseases with multifactorial etiology. The first-line therapy includes monotherapy, which often fails to achieve effective glycemic control, necessitating the addition of add-on therapy. In this regard, multiple single-dose combinations called fixed-dose combinations (FDCs) have been evaluated for their safety, efficacy, and tolerability. To analyze the rationality of diverse FDCs used in the remedy Diabetes Mellitus and to find out the irrational FDCs existing in Indian market. A overall of 18 mixtures had been analyzed, amongst the ones 11 combinations had been irrational. Predominantly irrational FDCs are being circulated within the Indian market as a result thru analyses by way of prescribers is wanted earlier than prescribing to patients a good way to keep away from ADR. This requires a near scrutiny of advertised FDCs and educating prescribers to apply them with first rate care and caution also suggests an extreme evaluation of regulatory framework for drug production and marketing. An assessment of the pharmacology and scientific consequences from current hearings of the metformin-sitagliptin mixture and the way the mixture could in shape into the sort 2 diabetes remedy algorithms is obtainable on the evaluation.

Bismuth-Based First-Line Therapy for Helicobacter pylori Eradication in Type 2 Diabetes Mellitus Patients

Digestion ◽  
2010 ◽  
Vol 82 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Mehmet Demir ◽  
Savaş Göktürk ◽  
Nevin Akçaer Öztürk ◽  
Ender Serin ◽  
Uğur Yilmaz
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Helicobacter Pylori ◽  
Type 2 Diabetes Mellitus ◽  
First Line ◽  
Helicobacter Pylori Eradication ◽  
First Line Therapy ◽  
Line Therapy
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