scholarly journals Neuropathic pain: mechanisms and their clinical implications

BMJ ◽  
2014 ◽  
Vol 348 (feb05 6) ◽  
pp. f7656-f7656 ◽  
Author(s):  
S. P. Cohen ◽  
J. Mao
Keyword(s):  
Neuropathic Pain ◽  
Clinical Implications ◽  
Pain Mechanisms

scholarly journals Needling Interventions for Sciatica: Choosing Methods Based on Neuropathic Pain Mechanisms—A Scoping Review

2021 ◽  
Vol 10 (10) ◽  
pp. 2189
Author(s):  
Thomas Perreault ◽  
César Fernández-de-las-Peñas ◽  
Mike Cummings ◽  
Barry C. Gendron
Keyword(s):  
Neuropathic Pain ◽  
Effective Treatment ◽  
Scoping Review ◽  
Reference Lists ◽  
Current Evidence ◽  
Review Of The Literature ◽  
Dry Needling ◽  
Pain Mechanisms ◽  
Literature Searches ◽  
Cochrane Database

Sciatica is a condition often accompanied by neuropathic pain (NP). Acupuncture and dry needling are common treatments for pain, and the current literature supports acupuncture as an effective treatment for sciatica. However, it is unknown if the mechanisms of NP are considered in the delivery of needling interventions for sciatica. Our objective was to assess the efficacy and the effectiveness of needling therapies, to identify common needling practices and to investigate if NP mechanisms are considered in the treatment of sciatica. A scoping review of the literature on needling interventions for sciatica and a review of the literature on mechanisms related to NP and needling interventions were performed. Electronic literature searches were conducted on PubMed, MEDLINE, CINAHL and Cochrane Database of Systematic Reviews from inception to August, 2020 to identify relevant papers. Reference lists of included papers were also manually screened and a related-articles search through PubMed was performed on all included articles. Mapping of the results included description of included studies, summary of results, and identification of gaps in the existing literature. Ten articles were included. All studies used acupuncture for the treatment of sciatica, no studies on dry needling were identified. Current evidence supports the efficacy and effectiveness of acupuncture for sciatica, however, no studies considered underlying NP mechanisms in the acupuncture approach for sciatica and the rationale for using acupuncture was inconsistent among trials. This review reveals that neuropathic pain mechanisms are not routinely considered in needling approaches for patients with sciatica. Studies showed acupuncture to be an effective treatment for sciatic pain, however, further research is warranted to explore if needling interventions for sciatica and NP would be more effective if NP mechanisms are considered.

scholarly journals Satellite Glial Cell P2Y12Receptor in the Trigeminal Ganglion is Involved in Lingual Neuropathic Pain Mechanisms in Rats

2012 ◽  
Vol 8 ◽  
pp. 1744-8069-8-23 ◽  
Author(s):  
Ayano Katagiri ◽  
Masamichi Shinoda ◽  
Kuniya Honda ◽  
Akira Toyofuku ◽  
Barry J Sessle ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Glial Cell ◽  
Trigeminal Ganglion ◽  
Pain Mechanisms ◽  
Satellite Glial Cell

scholarly journals Src Family Kinases in the Central Nervous System：Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain

2020 ◽  
Vol 18 ◽  
Author(s):  
Lingdi Nie ◽  
Wen-Rui Ye ◽  
Shangbin Chen ◽  
Domenico Chirchiglia ◽  
Minyan Wang
Keyword(s):  
Neuropathic Pain ◽  
Tyrosine Kinases ◽  
Neurological Diseases ◽  
Src Family Kinases ◽  
Signalling Pathways ◽  
Pain Mechanisms ◽  
Promising Therapeutic Target ◽  
The Central Nervous System ◽  
The Relationship

: Src family kinases (SFK) are a group of non-receptor tyrosine kinases which play a pivotal role in cellular responses and oncogenesis. Accumulating evidence suggest that SFK also act as a key component in signalling pathways of the central nervous system (CNS) in both physiological and pathological conditions. Despite the crucial role of SFK in signal transduction of the CNS, the relationship between SFK and molecules implicated in pain has been relatively unexplored. This article briefly reviews the recent advances uncovering the interplay of SFK with diverse membrane proteins and intracellular proteins in the CNS and the importance of SFK in the pathophysiology of migraine and neuropathic pain. Mechanisms underlying the role of SFK in these conditions and potential clinical applications of SFK inhibitors in neurological diseases are also summarised. We propose that SFK are the convergent point of signalling pathways in migraine and neuropathic pain and may constitute a promising therapeutic target for these diseases.

Neuropathic Pain Mechanisms and Imaging

2015 ◽  
Vol 19 (02) ◽  
pp. 103-111 ◽  
Author(s):  
Ka-Wah Tung ◽  
Deepak Behera ◽  
Sandip Biswal
Keyword(s):  
Neuropathic Pain ◽  
Pain Mechanisms

Neuropathic pain in patients with haemophilia, that is the question

2015 ◽  
Vol 35 (S 01) ◽  
pp. S5-S9 ◽  
Author(s):  
S. Krüger ◽  
T. Hilberg
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Pain ◽  
Neuropathic Pain ◽  
Differential Diagnosis ◽  
Pain Management ◽  
Pain Mechanisms ◽  
Number Of Patients ◽  
Paindetect Questionnaire ◽  
Chronic Disorders ◽  
Chronic Pain Conditions

SummaryChronic pain caused by recurrent joint bleedings affects a large number of patients with haemophilia (PwH). The basis of this pain, nociceptive or neuropathic, has not been investigated so far. In other pain-related chronic disorders such as osteoarthritis or rheumatoid arthritis, initial studies showed nociceptive but also neuropathic pain features. 137 PwH and 33 controls (C) completed the painDETECT-questionnaire (pDq), which identifies neuropathic components in a person´s pain profile. Based on the pDq results, a neuropathic pain component is classified as positive, negative or unclear. A positive neuropathic pain component was found in nine PwH, but not in C. In 20 PwH an unclear pDq result was observed. In comparison to C the allocation of pDq results is statistically significant (p≤0.001). Despite various pDq results in PwH and C a similar appraisal pain quality, but on a different level, was determined. Summarising the results, there is a potential risk to misunderstand underlying pain mechanisms in PwH. In chronic pain conditions based on haemophilic arthopathy, a differential diagnosis seems to be unalterable for comprehensive and individualised pain management in PwH.

scholarly journals Neurosurgery for Chronic Neuropathic Pain

2000 ◽  
Vol 5 (1) ◽  
pp. 101-106
Author(s):  
Jung Y Park ◽  
Andres M Lozano
Keyword(s):  
Neuropathic Pain ◽  
Deep Brain Stimulation ◽  
Motor Cortex ◽  
Chronic Neuropathic Pain ◽  
Pain Mechanisms ◽  
Surgical Interventions ◽  
Spinal Motor ◽  
Limited Efficacy ◽  
Ablative Procedures ◽  
Deep Brain

Neurosurgery can play a role in the management of patients with refractory chronic neuropathic pain. However, selecting patients as candidates for surgery and choosing the most appropriate surgical procedure is challenging, and surgical interventions often have limited efficacy. When considering surgery, neuroaugmentative or neuromodulative procedures (eg, peripheral, spinal, motor cortex or deep brain stimulation) are generally preferred over ablative procedures as initial modalities. With better understanding of specific pain mechanisms, surgery will have more to offer patients with chronic neuropathic pain.

Neuropathic pain following spinal cord injury pain: mechanisms and treatment

2009 ◽  
Vol 1 ◽  
pp. S3-S11 ◽  
Author(s):  
Nanna Brix Finnerup ◽  
Cathrine Baastrup ◽  
Troels Staehelin Jensen
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Pain Mechanisms ◽  
Cord Injury ◽  
Spinal Cord Injury Pain
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