scholarly journals Derivation and validation of age and temperature specific reference values and centile charts to predict lower respiratory tract infection in children with fever: prospective observational study

BMJ ◽  
2012 ◽  
Vol 345 (jul03 1) ◽  
pp. e4224-e4224 ◽  
Author(s):  
R. G. Nijman ◽  
M. Thompson ◽  
M. van Veen ◽  
R. Perera ◽  
H. A. Moll ◽  
...  
Keyword(s):  
Tract Infection ◽  
Observational Study ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract Infection ◽  
Reference Values ◽  
Lower Respiratory Tract ◽  
Prospective Observational Study ◽  
Specific Reference

scholarly journals Is Viral Co-infection A Risk Factor For Severe Lower Respiratory Tract Infection? A Retrospective Observational Study

2021 ◽  
Author(s):  
Aykut Eşki ◽  
Gökçen Kartal Öztürk ◽  
Candan Çiçek ◽  
Figen Gülen ◽  
Esen Demir
Keyword(s):  
Risk Factors ◽  
Virus Infection ◽  
Tract Infection ◽  
Observational Study ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract Infection ◽  
Lower Respiratory Tract ◽  
Influenza A ◽  
Viral Coinfection

Objective: To determine whether viral coinfection is a risk for severe lower respiratory tract infection (LRTI). Working Hypothesis: Children with viral coinfection had a higher risk for admission to the intensive care unit (ICU) than those with a single virus infection. Study Design: Retrospective, observational study for ten years. Patient-Subject Selection: Children between 1-60 months of age hospitalized with LRTI. Methodology: We defined severe LRTI as admission to the ICU for high-flow nasal cannula oxygen/bilevel positive airway pressure/invasive ventilation and assessed demographic and laboratory data with potential risk factors from the patients’ medical records. Results: Of 2115 children hospitalized with LRTI, 562 had severe, and 1553 had mild disease. Viral coinfection was present in 28.3% of all patients, and those with viral coinfection were at a higher risk of severe LRTI than those with a single virus infection (43.8% vs. 22.7%; aOR, 3.44; 95% CI, 2.74-4.53). Respiratory syncytial virus (RSV) and rhinovirus (except for between 25-60 months) coinfections were associated with severe LRTI in all ages, whereas parainfluenza virus-3 (PIV3; 7-24 months) and bocavirus (7-12 months) coinfections led to severe LRTI in early childhood. Moreover, influenza-A coinfection caused severe LRTI in children between 7-12 and 25-60 months. Other risk factors included young age, prematurity, history of atopy, exposure to tobacco smoke, underlying condition, neutrophilia, lymphopenia, and high CRP value. Conclusion: Children with viral coinfection, particularly with rhinovirus, RSV, influenza-A, PIV3, and bocavirus, may be followed closely regarding the clinical changes.

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