scholarly journals Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants' allergies in first year of life: randomised controlled trial

BMJ ◽  
2012 ◽  
Vol 344 (jan30 2) ◽  
pp. e184-e184 ◽  
Author(s):  
D. J. Palmer ◽  
T. Sullivan ◽  
M. S. Gold ◽  
S. L. Prescott ◽  
R. Heddle ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Chain Polyunsaturated Fatty Acid ◽  
First Year ◽  
Fatty Acid Supplementation ◽  
Randomised Controlled ◽  
First Year Of Life ◽  
Long Chain ◽  
In Pregnancy

scholarly journals No effect ofn-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial

2008 ◽  
Vol 99 (2) ◽  
pp. 421-431 ◽  
Author(s):  
Peter J. Rogers ◽  
Katherine M. Appleton ◽  
David Kessler ◽  
Tim J. Peters ◽  
David Gunnell ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cognitive Function ◽  
Randomised Controlled Trial ◽  
Depressed Mood ◽  
Controlled Trial ◽  
Chain Polyunsaturated Fatty Acid ◽  
Epa And Dha ◽  
Increased Risk ◽  
Randomised Controlled ◽  
Long Chain

Low dietary intakes of then-3 long-chain PUFA (LCPUFA) EPA and DHA are thought to be associated with increased risk for a variety of adverse outcomes, including some psychiatric disorders. Evidence from observational and intervention studies for a role ofn-3 LCPUFA in depression is mixed, with some support for a benefit of EPA and/or DHA in major depressive illness. The present study was a double-blind randomised controlled trial that evaluated the effects of EPA+DHA supplementation (1·5 g/d) on mood and cognitive function in mild to moderately depressed individuals. Of 218 participants who entered the trial, 190 completed the planned 12 weeks intervention. Compliance, confirmed by plasma fatty acid concentrations, was good, but there was no evidence of a difference between supplemented and placebo groups in the primary outcome – namely, the depression subscale of the Depression Anxiety and Stress Scales at 12 weeks. Mean depression score was 8·4 for the EPA+DHA group and 9·6 for the placebo group, with an adjusted difference of − 1·0 (95 % CI − 2·8, 0·8;P = 0·27). Other measures of mood, mental health and cognitive function, including Beck Depression Inventory score and attentional bias toward threat words, were similarly little affected by the intervention. In conclusion, substantially increasing EPA+DHA intake for 3 months was found not to have beneficial or harmful effects on mood in mild to moderate depression. Adding the present result to a meta-analysis of previous relevant randomised controlled trial results confirmed an overall negligible benefit ofn-3 LCPUFA supplementation for depressed mood.

scholarly journals No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial – reply by Rogers et al.

2008 ◽  
Vol 100 (6) ◽  
pp. 1349-1351 ◽  
Author(s):  
Peter J. Rogers ◽  
Katherine M. Appleton ◽  
David Kessler ◽  
Tim J. Peters ◽  
David Gunnell ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cognitive Function ◽  
Randomised Controlled Trial ◽  
Depressed Mood ◽  
Controlled Trial ◽  
Chain Polyunsaturated Fatty Acid ◽  
Pufa Supplementation ◽  
Chain Pufa ◽  
Randomised Controlled ◽  
Long Chain

We recently reported a null outcome from a study of n-3 long-chain PUFA supplementation in depressed mood(1).

Sign in / Sign up

Export Citation Format

Share Document