scholarly journals Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003

BMJ ◽  
2010 ◽  
Vol 340 (jan14 1) ◽  
pp. b5349-b5349 ◽  
Author(s):  
Y. Shimizu ◽  
K. Kodama ◽  
N. Nishi ◽  
F. Kasagi ◽  
A. Suyama ◽  
...  
Keyword(s):  
Radiation Exposure ◽  
Atomic Bomb ◽  
Disease Risk ◽  
Atomic Bomb Survivor ◽  
Circulatory Disease

Gray Matter Heterotopia: Histological Evidence of Intrauterine Radiation Exposure in a Nagasaki Atomic Bomb Survivor

2019 ◽  
Vol 192 (6) ◽  
pp. 666
Author(s):  
Yuko Akazawa ◽  
Masahiro Ito ◽  
Shinji Naito ◽  
Masao Kishikawa ◽  
Ichiro Sekine ◽  
...  
Keyword(s):  
Radiation Exposure ◽  
Gray Matter ◽  
Atomic Bomb ◽  
Atomic Bomb Survivor ◽  
Histological Evidence

scholarly journals Radiation effects on atherosclerosis in atomic bomb survivors: a cross‐sectional study using structural equation modeling

2021 ◽  
Vol 36 (4) ◽  
pp. 401-414
Author(s):  
Tomoki Nakamizo ◽  
John Cologne ◽  
Kismet Cordova ◽  
Michiko Yamada ◽  
Tetsuya Takahashi ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Radiation Exposure ◽  
Structural Equation ◽  
Atomic Bomb ◽  
Cross Sectional Study ◽  
Equation Modeling ◽  
Study Cohort ◽  
Sectional Study ◽  
Cross Sectional ◽  
Atomic Bomb Survivors

AbstractPast reports indicated that total-body irradiation at low to moderate doses could be responsible for cardiovascular disease risks, but the mechanism remains unclear. The purpose of this study was to investigate the association between radiation exposure and atherosclerosis, an underlying pathology of cardiovascular diseases, in the Japanese atomic bomb survivors. We performed a cross-sectional study measuring 14 clinical-physiological atherosclerosis indicators during clinical exams from 2010 to 2014 in 3274 participants of the Adult Health Study cohort. Multivariable analyses were performed by using a structural equation model with latent factors representing underlying atherosclerotic pathologies: (1) arterial stiffness, (2) calcification, and (3) plaque　as measured with indicators chosen a priori on the basis of clinical-physiological knowledge. Radiation was linearly associated with calcification (standardized coefficient per Gy 0.15, 95 % confidence interval: CI [0.070, 0.23]) and plaque (0.11, 95 % CI [0.029, 0.20]), small associations that were comparable to about 2 years of aging per Gy of radiation exposure, but not with arterial stiffness (0.036, 95 % CI [− 0.025, 0.095]). The model fitted better and had narrower confidence intervals than separate ordinary regression models explaining individual indicators independently. The associations were less evident when the dose range was restricted to a maximum of 2 or 1 Gy. By combining individual clinical-physiological indicators that are correlated because of common, underlying atherosclerotic pathologies, we found a small, but significant association of radiation with atherosclerosis.

scholarly journals Radiation Risks of Uterine Cancer in Atomic Bomb Survivors: 1958–2009

2018 ◽  
Vol 2 (4) ◽  
Author(s):  
Mai Utada ◽  
Alina V Brenner ◽  
Dale L Preston ◽  
John B Cologne ◽  
Ritsu Sakata ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Radiation Exposure ◽  
Radiation Effect ◽  
Atomic Bomb ◽  
Uterine Cancer ◽  
Radiation Risk ◽  
Atomic Bomb Survivors ◽  
Exposure Age ◽  
Modifying Effect ◽  
Effect Of Age

Abstract Background Ionizing radiation is known to be capable of causing cancer of many organs, but its relationship with uterine cancer has not been well characterized. Methods We studied incidence of uterine cancer during 1958–2009 among 62 534 female atomic bomb survivors. Using Poisson regression analysis, we fitted excess relative risk (ERR) models to uterine cancer rates adjusted for several lifestyle and reproductive factors. Person-years at risk were also adjusted for the probability of prior hysterectomy, because it could affect the subsequent risk of uterine cancer. We assessed the modifying effect of age and other factors on the radiation risk. For analysis of the modifying effect of age at radiation exposure around menarche, we compared the radiation risk for several exposure-age categories as well as using parametric models. Results There were 224 uterine corpus cancers and 982 cervical cancers. We found a significant association between radiation dose and risk of corpus cancer (ERR per Gray [ERR/Gy] = 0.73, 95% confidence interval [CI] = 0.03 to 1.87) but not for cervical cancer (ERR/Gy = 0.00, 95% CI = −0.22 to 0.31). For corpus cancer, we found statistically significant heterogeneity in ERR/Gy by age (Pheterogeneity = .001) with elevated risk for women exposed to radiation between ages 11 and 15 years (ERR/Gy = 4.10, 95% CI = 1.47 to 8.42) and no indication of a radiation effect for exposures before or after this exposure-age range. Conclusions The current data suggest that uterine corpus is especially sensitive to the carcinogenic effect of radiation exposure occurring during the mid-pubertal period preceding menarche. There is little evidence for a radiation effect on cervical cancer risk.

Occupational radiation exposure and morbidity of circulatory disease among diagnostic medical radiation workers in South Korea

2020 ◽  
Vol 77 (11) ◽  
pp. 752-760
Author(s):  
Eun Shil Cha ◽  
Lydia B Zablotska ◽  
Ye Jin Bang ◽  
Won Jin Lee
Keyword(s):  
South Korea ◽  
Radiation Exposure ◽  
Circulatory Disease ◽  
Occupational Radiation Exposure ◽  
Relative Risks ◽  
Medical Radiation ◽  
Radiation Workers ◽  
Occupational Radiation ◽  
Circulatory Diseases

ObjectivesWe investigated the association between low-dose external occupational radiation exposure and circulatory disease morbidity among diagnostic medical radiation workers.MethodsA cohort of 11 500 diagnostic medical radiation workers was linked with the National Dosimetry Registry data and the National Health Insurance Service data. Relative risks (RRs) were calculated to explore the association between occupational factors and circulatory disease morbidity, and excess relative risks per 100 milligray (ERR/100 mGy) were estimated to quantify the radiation dose-response relationship.ResultsOverall, there were 2270 cases of circulatory diseases during 93 696 person-years of observation (average follow-up=8.1 years). RRs for hypertension were significantly increased for individuals who started working before 2000 compared with those who started in 2005 and later. ERR/100 mGy for all circulatory diseases was 0.14 (95% CI −0.57 to 0.99). Radiation risks of cerebrovascular diseases and ischaemic heart disease were non-significantly increased with estimates of individual cumulative doses to the heart (ERR/100 mGy=3.10 (−0.75 to 11.59) and 1.22 (−0.71 to 4.73), respectively). However, ERR estimates were generally more strongly positive for female versus male workers and for younger workers versus more than 50-year-old workers.ConclusionsThis study provides little evidence in support of a positive association between occupational radiation exposure and the overall risk of circulatory disease over a short follow-up period among medical radiation workers in South Korea. However, significantly increased RR with earlier year first worked, elevated ERR in female workers and young workers should be further followed up.

Abstract 2209: Effects ofIL10haplotypes and atomic bomb radiation exposure on risks of gastric cancer subtypes

2014 ◽  
Author(s):  
Tomonori Hayashi ◽  
John B. Cologne ◽  
Yiqun Hu ◽  
Kengo Yoshida ◽  
Waka Ohishi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Radiation Exposure ◽  
Atomic Bomb ◽  
Cancer Subtypes
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