scholarly journals Temperature Records and Ovarian Activity

BMJ ◽  
1948 ◽  
Vol 1 (4558) ◽  
pp. 952-953
Author(s):  
P. M. F. Bishop
Keyword(s):  
Ovarian Activity ◽  
Temperature Records

scholarly journals Temperature Records and Ovarian Activity

BMJ ◽  
1948 ◽  
Vol 1 (4555) ◽  
pp. 806-807
Author(s):  
M. Barton
Keyword(s):  
Ovarian Activity ◽  
Temperature Records

EFFECT OF DYDROGESTERONE ON HUMAN ENDOMETRIUM AND OVARIAN ACTIVITY

1962 ◽  
Vol 40 (2) ◽  
pp. 203-216 ◽  
Author(s):  
P. M. F. Bishop ◽  
U. Borell ◽  
E. Diczfalusy ◽  
K.-G. Tillinger
Keyword(s):  
Corpus Luteum ◽  
Ovarian Activity ◽  
Temperature Pattern ◽  
Pharmacological Properties ◽  
Human Female ◽  
Daily Dose ◽  
Menstruating Women ◽  
Temperature Records ◽  
Derivatives Of ◽  
Artificial Cycle

ABSTRACT Some of the pharmacological properties of dydrogesterone (9β,10α-pregna-4,6-diene-3,20-dione) were studied in the human female. When dydrogesterone was administered by mouth in daily doses of 10 mg for 10 to 14 days to amenorrhoeic women primed with ethinyloestradiol progestational transformation of the endometrium was found in 30 out of 32 artificial cycles. When administration of ethinyloestradiol was not continued until the end of the artificial cycle, break-through bleeding occurred in 30 out of 35 occasions, whereas it took place in only 9 out of 30 cycles, when ethinyloestradiol was given throughout the cycle. Dydrogesterone was administered in 77 cycles to women with incapacitating dysmenorrhoea from the 5th to the 25th day. When the daily dose was 10 mg, the subsequent period was not incapacitating on 20 out of 31 occasions whereas with daily doses of 15 or 20 mg the corresponding results were 40 out of 46. Forty-eight out of 60 cycles labelled »not incapacitating« were completely painless. No side-effects whatsover were observed. Studies of basal temperature records in amenorrhoeic and dysmenorrhoeic women indicate that dydrogesterone has no thermogenic activity. When the compound was given to normally menstruating women in daily doses of 10 to 40 mg from the beginning of the cycle, it did not interfere with the characteristic biphasic temperature pattern, with the urinary excretion of oestrogen and pregnanediol or with the formation of a corpus luteum as proved at laparotomy. Even following the administration of as much as 400 mg per day a corpus luteum was found. It is concluded therefore, that dydrogesterone does not inhibit ovulation. In a previous paper the effect of alterations in the stereochemical configuration of steroid hormones at C-9 and C-10 on their pharmacological properties was reported (Reerink et al. 1960). Among various derivatives of 9β,10α-progesterone (retro-progesterone) tested, one, 9β,10α-pregna-4,6-diene-3,20-dione (hereafter referred to as »dydrogesterone«), see Fig. 1, was found to be a potent progestational agent when administered orally to rabbits (Schöler 1960) and to amenorrhoeic women (Tillinger & Diczfalusy 1960). The purpose of the present communication is to report on some of the pharmacological properties of this compound in the human female.

Ovarian Activity in Prepuberal Dairy Calves

1962 ◽  
Vol 21 (1) ◽  
pp. 82-90 ◽  
Author(s):  
G. R. Howe ◽  
D. L. Black ◽  
R. C. Foley ◽  
W. G. Black
Keyword(s):  
Dairy Calves ◽  
Ovarian Activity

Premature ovarian ageing following heterozygous loss of Senataxin

2020 ◽  
Author(s):  
G N Subramanian ◽  
M Lavin ◽  
H A Homer
Keyword(s):  
Dna Damage ◽  
Neurodegenerative Disorder ◽  
Dna Helicase ◽  
Dna Integrity ◽  
Ovarian Activity ◽  
Homozygous Mutation ◽  
Female Mice ◽  
Mating Trial ◽  
High Prevalence

Abstract Premature loss of ovarian activity before 40 years of age is known as primary ovarian insufficiency (POI) and occurs in ∼1% of women. A more subtle decline in ovarian activity, known as premature ovarian ageing (POA), occurs in ∼10% of women. Despite the high prevalence of POA, very little is known regarding its genetic causation. Senataxin (SETX) is an RNA/DNA helicase involved in repair of oxidative stress-induced DNA damage. Homozygous mutation of SETX leads to the neurodegenerative disorder, ataxia oculomotor apraxia type 2 (AOA2). There have been reports of POI in AOA2 females suggesting a link between SETX and ovarian ageing. Here, we studied female mice lacking either one (Setx+/−) or both (Setx−/−) copies of SETX over a 12- to 14-month period. We find that DNA damage is increased in oocytes from 8-month-old Setx+/− and Setx−/− females compared with Setx+/+ oocytes leading to a marked reduction in all classes of ovarian follicles at least 4 months earlier than typically occurs in female mice. Furthermore, during a 12-month long mating trial, Setx+/− and Setx−/− females produced significantly fewer pups than Setx+/+ females from 7 months of age onwards. These data show that SETX is critical for preventing POA in mice, likely by preserving DNA integrity in oocytes. Intriguingly, heterozygous Setx loss causes an equally severe impact on ovarian ageing as homozygous Setx loss. Because heterozygous SETX disruption is less likely to produce systemic effects, SETX compromise could underpin some cases of insidious POA.

Ovarian activity in crossbred Thai native does during naturally occurring foot-and-mouth disease (FMD) virus infection

2021 ◽  
Vol 53 (2) ◽  
Author(s):  
Phubet Satsook ◽  
Sukanya Rattanatabtimtong ◽  
Lak Piasai ◽  
Patcharapa Towiboon ◽  
Chalermchart Somgird ◽  
...  
Keyword(s):  
Virus Infection ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Ovarian Activity ◽  
Fmd Virus ◽  
Naturally Occurring ◽  
Foot And Mouth

THE CONTROL OF OVARIAN ACTIVITY

1949 ◽  
Vol 4 (2) ◽  
pp. 248-249
Author(s):  
H. H. COLE
Keyword(s):  
Ovarian Activity

scholarly journals Intraruminal soluble glass boluses containing melatonin can induce early onset of ovarian activity in ewes

Reproduction ◽  
1987 ◽  
Vol 80 (1) ◽  
pp. 235-239 ◽  
Author(s):  
A. L. Poulton ◽  
A. M. Symons ◽  
M. I. Kelly ◽  
J. Arendt
Keyword(s):  
Early Onset ◽  
Ovarian Activity ◽  
Soluble Glass
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