scholarly journals Screening for primary angle closure in Mongolia: a randomised controlled trial to determine whether screening and prophylactic treatment will reduce the incidence of primary angle closure glaucoma in an east Asian population

2003 ◽  
Vol 87 (3) ◽  
pp. 271-274 ◽  
Author(s):  
W P Nolan
Keyword(s):  
Randomised Controlled Trial ◽  
Prophylactic Treatment ◽  
Controlled Trial ◽  
East Asian ◽  
Asian Population ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Randomised Controlled

scholarly journals Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a randomised controlled trial

The Lancet ◽  
2016 ◽  
Vol 388 (10052) ◽  
pp. 1389-1397 ◽  
Author(s):  
Augusto Azuara-Blanco ◽  
Jennifer Burr ◽  
Craig Ramsay ◽  
David Cooper ◽  
Paul J Foster ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Lens Extraction ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Randomised Controlled

scholarly journals Efficacy and safety of phacotrabeculectomy versus phacogoniotomy in advanced primary angle-closure glaucoma: study protocol for a multicentre non-inferiority randomised controlled trial (PVP Study)

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e056876
Author(s):  
Yunhe Song ◽  
Wulian Song ◽  
Yi Zhang ◽  
Hengli Zhang ◽  
Meichun Xiao ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Controlled Clinical Trial ◽  
Efficacy And Safety ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Randomised Controlled

IntroductionPrimary angle-closure glaucoma (PACG) has a high prevalence and blinding rate across Asia. The first-line treatment of PACG is surgery, and phacotrabeculectomy remains the mainstream surgery for advanced PACG. However, it may cause vision-threatening complications with long learning curve. Minimally invasive glaucoma surgery has been gradually used in PACG combined with cataract surgery and achieved efficacy without excessive injury, of which goniotomy is the most commonly performed. Therefore, this study aimed to conduct a multicentre, non-inferiority randomised controlled clinical trial to compare the efficacy and safety of phacotrabeculectomy versus phacogoniotomy in advanced PACG.Methods and analysisThis is a non-inferiority multicentre randomised controlled trial and will be conducted at eight ophthalmic departments and institutes in China. 124 patients with advanced PACG will be enrolled and randomised to undergo phacotrabeculectomy or phacogoniotomy. Comprehensive ophthalmic examinations will be performed before and after the surgery. The primary outcome is the change of intraocular pressure at 12 months after surgery compared with the baseline intraocular pressure. An extended follow-up period of 36 months will be required. Cumulative success rate of surgery, intraoperative and postoperative complications, and number of anti-glaucomatous medications will also be compared between the groups as secondary outcomes.Ethics and disseminationEthical approval has been obtained from the ethical committee of Zhongshan Ophthalmic Center, Sun Yat-sen University, China (ID: 2021KYPJ090) and all subcentres. All the participants will be required to provide written informed consent. The results will be disseminated through scientific meetings and published in peer-reviewed journals.Trial registration numberNCT04878458.

scholarly journals Clear lens extraction for the management of primary angle closure glaucoma: surgical technique and refractive outcomes in the EAGLE cohort

2018 ◽  
Vol 102 (12) ◽  
pp. 1658-1662 ◽  
Author(s):  
Alexander C Day ◽  
David Cooper ◽  
Jennifer Burr ◽  
Paul J Foster ◽  
David S Friedman ◽  
...  
Keyword(s):  
Surgical Technique ◽  
Controlled Trial ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Laser Peripheral Iridotomy ◽  
Lens Extraction ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Refractive Outcomes ◽  
Randomised Controlled

BackgroundTo describe the surgical technique and refractive outcomes following clear lens extraction (CLE) in the Effectiveness, in Angle-closure Glaucoma, of Lens Extraction trial.MethodsReview of prospectively collected data from a multicentre, randomised controlled trial comparing CLE and laser peripheral iridotomy. Eligible participants were ≥50 years old and newly diagnosed with (1) primary angle closure (PAC) with intraocular pressure above 30 mm Hg or (2) PAC glaucoma. We report the postoperative corrected distance visual acuity (CDVA) and refractive outcomes at 12 and 36 months postoperatively for those who underwent CLE.ResultsOf the 419 participants, 208 were randomised to CLE. Mean baseline CDVA was 77.9 (SD 12.4) letters and did not change significantly at 36 months when mean CDVA was 79.9 (SD 10.9) letters. Mean preoperative spherical equivalents were +1.7 (SD 2.3) and +0.08 (SD 0.95) diopters (D) at 36 months. Fifty-nine per cent and 85% eyes were within ±0.5D and ±1.0D of predicted refraction, respectively, at 36 months.ConclusionsMean CDVA in patients undergoing CLE for angle-closure glaucoma appeared stable over the 3-year study period. Refractive error was significantly reduced with surgery but refractive predictability was suboptimal.Trial registration number

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