scholarly journals Prevalence of ocular symptoms and signs with preserved and preservative free glaucoma medication

2002 ◽  
Vol 86 (4) ◽  
pp. 418-423 ◽  
Author(s):  
P J Pisella
Keyword(s):  
Glaucoma Medication ◽  
Ocular Symptoms ◽  
Symptoms And Signs ◽  
Preservative Free

Ocular Symptoms and Signs with Preserved and Preservative-Free Glaucoma Medications

2007 ◽  
Vol 17 (3) ◽  
pp. 341-349 ◽  
Author(s):  
N. Jaenen ◽  
C. Baudouin ◽  
P. Pouliquen ◽  
G. Manni ◽  
A. Figueiredo ◽  
...  
Keyword(s):  
Ocular Symptoms ◽  
Symptoms And Signs ◽  
Preservative Free

Objective ocular surface tolerance in patients with glaucoma treated with topical preserved or unpreserved prostaglandin analogues

2018 ◽  
Vol 29 (6) ◽  
pp. 645-653 ◽  
Author(s):  
Ammar El Ameen ◽  
Guillaume Vandermeer ◽  
Raoul K Khanna ◽  
Pierre-Jean Pisella
Keyword(s):  
Intraocular Pressure ◽  
Prostaglandin Analogue ◽  
Ocular Toxicity ◽  
Prostaglandin Analogues ◽  
Conjunctival Hyperaemia ◽  
Ocular Symptoms ◽  
Tear Meniscus ◽  
Tear Meniscus Height ◽  
Preservative Free ◽  
Ocular Signs

Purpose: Preservatives in glaucoma medications have been associated with ocular toxicity. We compared ocular signs and symptoms in patients with open-angle glaucoma or ocular hypertension treated in monotherapy with preserved or preservative-free prostaglandin analogues. Methods: Observational cross-sectional clinical study in real life. 82 patients treated for at least 6 months with prostaglandin analogue were assessed for intraocular pressure, ocular symptoms and ocular signs including conjunctival hyperaemia, tear break-up time and tear meniscus height measured using objective and non-invasive methods (OCULUS Keratograph 5M). Patients presenting with symptoms of ocular toxicity with preserved prostaglandin analogues were switched to preservative-free latanoprost, and a second assessment was processed 6 months after. Results: At inclusion, 30 (36.6%) patients were treated with preservative-free latanoprost, 25 (30.5%) with preserved latanoprost, 16 (19.5%) with preserved travoprost and 11 (13.4%) with preserved bimatoprost. Patients treated with preservative-free latanoprost reported significantly less ocular symptoms upon instillation (mainly burning) and between instillations than patients treated with preserved prostaglandin analogues. The mean conjunctival hyperaemia (limbal + bulbar) was significantly lower with preservative-free latanoprost (2.08 ± 0.55) compared to preserved latanoprost (2.50 ± 0.7, p = 0.0085), preserved travoprost (2.67 ± 0.82, p = 0.0083) and preserved bimatoprost (2.68 ± 0.67, p = 0.0041). There were no relevant between-group differences in mean tear meniscus height and break-up time. Ocular symptoms and conjunctival hyperaemia improved when preserved prostaglandin analogues were switched to preservative-free latanoprost for 6 months while intraocular pressure reduction was maintained. Conclusion: Overall, this study suggests a better subjective and objective ocular tolerance when patients were treated with preservative-free latanoprost than with other preserved prostaglandin analogues monotherapy. Switching to preservative-free latanoprost maintained intraocular pressure at the same level as preservative prostaglandin analogue, but improved ocular surface tolerance.

scholarly journals Preservatives in glaucoma medication

2018 ◽  
Vol 102 (11) ◽  
pp. 1497-1503 ◽  
Author(s):  
David W Steven ◽  
Pouya Alaghband ◽  
Kin Sheng Lim
Keyword(s):  
Supporting Evidence ◽  
Laboratory Studies ◽  
Regulatory Requirements ◽  
Glaucoma Medication ◽  
Clinically Significant ◽  
Extensive Body ◽  
Randomised Controlled ◽  
Preservative Free

Preservatives continue to be in widespread use in ophthalmic medications due to the convenience they provide, regulatory requirements and the higher cost of alternatives. Benzalkonium chloride (BAK) remains the most commonly used preservative but there is a trend towards the use of preservative-free (PF) drops for glaucoma, although at a higher price. An extensive body of literature explores BAK toxicity on ocular structures in animal and laboratory studies (in vitro and in vivo). Non-randomised controlled studies have provided some supporting evidence of its toxicity in patients, especially in those with pre-existing ocular surface disease (OSD) or on multiple medications. However, there have been very few randomised controlled trials that compare the same medication with and without BAK preservative. Several of these trials have never been published in any peer reviewed journals. Notwithstanding, those that have been published, have not demonstrated any clear benefits of the BAK-free formulations. Short duration and exclusion of those with OSD are limitations of these studies. There is a lack of evidence of clinically significant harm from a small number of BAK preserved drops in patients without OSD. This means that generally more expensive PF glaucoma medications should only be recommended for those on poly pharmacy or those with OSD but are not necessarily required for all patients.

scholarly journals Dural Arteriovenous Fistula within the Hypoglossal Canal Successfully Treated by Transvenous Embolization

2004 ◽  
Vol 10 (1) ◽  
pp. 59-62 ◽  
Author(s):  
Y. Arai ◽  
H. Ishii ◽  
Y. Handa ◽  
Y. Ueda ◽  
N. Shirasaki ◽  
...  
Keyword(s):  
Complete Resolution ◽  
Dural Arteriovenous Fistula ◽  
Jugular Bulb ◽  
Left Vertebral Artery ◽  
Transvenous Embolization ◽  
Superior Ophthalmic Vein ◽  
Hypoglossal Canal ◽  
Ocular Symptoms ◽  
Venous Fistula ◽  
Symptoms And Signs

We report a case of dural arterio venous fistula (DAVF) within the left hypoglossal canal in a 64-year-old man who presented with tinnitus and ocular symptoms. Angiography revealed DAVF with the fistulous pouch medial to the left jugular bulb. The fistula was feeded by meningeal branches of the bilateral ascending pharyngeal arteries and the branches from the left vertebral artery. The fistula shunted into the left jugular bulb, with reflux into the left inferior petrosal (IPS) and cavernous sinuses (Cses), left superior ophthalmic vein (SO V) and cortical veins over the cerebral convexity. We performed transvenous coil embolization to occlude the fistula resulting in complete resolution of symptoms and signs.

Ocular symptoms and signs as presenting features of endocarditis caused byStreptococcus bovisII

2004 ◽  
Vol 65 (11) ◽  
pp. 694-695 ◽  
Author(s):  
Victor Menezo ◽  
Susan Lightman ◽  
Tun Kuan Yeo ◽  
Sidath Liyanage ◽  
William A Lynn
Keyword(s):  
Ocular Symptoms ◽  
Symptoms And Signs

scholarly journals A Survey of Seasonal and Perennial Allergic Conjunctivitis in Children in Southwest China: A Case-Control Study

2020 ◽  
Author(s):  
Xu Gao ◽  
Qin Xiang ◽  
Lan Hong
Keyword(s):  
Allergic Conjunctivitis ◽  
Southwest China ◽  
Allergic Diseases ◽  
House Dust Mites ◽  
Control Group ◽  
Case Group ◽  
Prick Test ◽  
Ocular Symptoms ◽  
Eye Exams ◽  
Symptoms And Signs

Abstract Background Seasonal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC) were the most usual types of allergic conjunctivitis. House dust mites were the most common sensitization agents for SAC and PAC. This study aimed to explore SAC and PAC risk factors in children.Methods We recruited 176 children suffering from SAC or PAC and 131 control subjects in southwest China. A questionnaire , several eye exams and the skin prick test (SPT) were performed.The scores of the symptoms/signs were recorded.Results The percentage of children that had ever been breastfed in the case group was lower than in the control group (P<0.05). The rate of parental allergy history in the case group was higher than for the control group (P<0.01). Compared with the control group, the case group was more likely to have other systemic allergic diseases (P<0.01).The incidence rate of adenoidal hypertrophy (ATH) in case group was higher than control group (P<0.05). The ocular symptoms and signs scores had significant correlation to the course (P<0.05), but no correlation to the SPT results (P>0.05).Conclusion Allergic conjunctivitis may coexist with a variety of allergic diseases, and SAC and PAC may be a risk factor for ATH. Breastfeeding should be recommended, as it may be an alleviating factor for allergic diseases, especially for children of parents with a history of allergic diseases. The disease severity is closely related to its course. Therefore, to avoid difficulty in treatment caused by the aggravation of symptoms and signs, timely antiallergic treatment was recommended.

scholarly journals A survey of seasonal and perennial allergic conjunctivitis in children in southwest China: a case-control study

2020 ◽  
Author(s):  
Xu Gao ◽  
Xiaojiao Tang ◽  
Qin Xiang
Keyword(s):  
Allergic Conjunctivitis ◽  
Southwest China ◽  
Allergic Diseases ◽  
House Dust Mites ◽  
Control Group ◽  
Case Group ◽  
Prick Test ◽  
Ocular Symptoms ◽  
Eye Exams ◽  
Symptoms And Signs

Abstract Background: Seasonal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC) were the most usual types of allergic conjunctivitis. House dust mites were the most common sensitization agents for SAC and PAC. This study aimed to explore SAC and PAC risk factors in children. Methods：We recruited 176 children suffering from SAC or PAC and 131 control subjects in southwest China. A questionnaire was provided to all the subjects’ parents. Several eye exams were performed, and all the subjects received the skin prick test (SPT). We analyzed the questionnaire data, the scores of the symptoms/signs and the SPT results. Results: The percentage of children that had ever been breastfed in the case group was lower than in the control group (P<0.05). The rate of parental allergy history in the case group was higher than for the control group (P<0.01). Compared with the control group, the case group was more likely to have other systemic allergic diseases (P<0.01). Some children in case group had adenoidal hypertrophy (ATH), and incidence rate was different from control group (P<0.05). The ocular symptoms and signs scores had significant correlation to the clinical course (P<0.05), but there was no correlation to the SPT results (P>0.05). Conclusion: Allergic conjunctivitis may coexist with a variety of allergic diseases, and SAC and PAC may be a risk factor for ATH. Breastfeeding should be recommended, as it may be an alleviating factor for allergic diseases, especially for children of parents with a history of allergic diseases. The disease severity is closely related to its course. Therefore, to avoid difficulty in treatment caused by the aggravation of symptoms and signs, timely antiallergic treatment was recommended.

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