scholarly journals Quantitative assessment of macular thickness in normal subjects and patients with diabetic retinopathy by scanning retinal thickness analyser

1999 ◽  
Vol 83 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Y. Oshima ◽  
K. Emi ◽  
S. Yamanishi ◽  
M. Motokura
Keyword(s):  
Diabetic Retinopathy ◽  
Quantitative Assessment ◽  
Retinal Thickness ◽  
Normal Subjects ◽  
Macular Thickness ◽  
Retinal Thickness Analyser

scholarly journals Assessing Errors Inherent in OCT-Derived Macular Thickness Maps

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Daniel Odell ◽  
Adam M. Dubis ◽  
Jackson F. Lever ◽  
Kimberly E. Stepien ◽  
Joseph Carroll
Keyword(s):  
Axial Length ◽  
Retinal Thickness ◽  
Normal Subjects ◽  
Macular Thickness ◽  
Ideal Observer ◽  
Factors Affecting ◽  
Data Collection And Analysis ◽  
Thickness Measurements ◽  
Retinal Pathologies ◽  
Sd Oct

SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness maps. Forty-three patients with various retinal pathologies and 113 normal subjects were imaged using Cirrus HD-OCT. Reduced B-scan density was associated with increased interpolation error in ETDRS macular thickness plots. Correcting for individual differences in axial length revealed modest errors in retinal thickness maps, while more pronounced errors were observed when the ETDRS plot was not positioned at the center of the fovea (which can occur as a result of errant fixation). Cumulative error can exceed hundreds of microns, even under “ideal observer” conditions. This preventable error is particularly relevant when attempting to compare macular thickness maps to normative databases or measuring the area or volume of retinal features.

scholarly journals Diabetic Retinopathy Vascular Density Maps Using Optical Coherence Topography Angiography

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
N A H Omran ◽  
A G Salman ◽  
Y A T Farweez ◽  
P S Saif
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Quantitative Assessment ◽  
Retinal Thickness ◽  
Vitreous Hemorrhage ◽  
Foveal Avascular Zone ◽  
Control Group ◽  
Vascular Density ◽  
Diabetic Patients ◽  
Optical Coherence

Abstract Background Diabetic retinopathy (DR) is one of the most common diabetic complications, which has become a leading cause for vision loss, mainly because of macular edema and vitreous hemorrhage. Objective Using Optical Coherence Tomography(OCT) and Optical Coherence Tomography Angiography (OCT-A) for qualitative and quantitative assessment of retinal vascular density in superficial capillary plexus, quantitative assessment of foveal avascular zone, choroidal vascular density map, assessment of retinal thickness and choroidal thickness in normal individuals and diabetic patients with and without diabetic retinopathy (DR). Patients and Methods This study included 64 eyes. Diabetics and control group were recruited from internal medicine clinic in Misr University for science and Technology Hospital and asked to participate in this study. This study was designed as an observational and cross sectional study in the period from 8/2018 to 2/2019. Results There is decrease in Choroidal vascular density in diabetic patients. There is decrease in retinal thickness in diabetic patients and there is no significant differences in the retinal thickness between control subjects and patients with NDR. Conclusion Our study suggested that OCTA can identify preclinical DR before the manifestation of clinically apparent retinopathy. Our findings highlight the potential role of OCT-A in monitoring and quantifying retinal vascular alterations in diabetes

scholarly journals Effect of Uncomplicated Cataract Surgery on Central Macular Thickness in Diabetic and Non-diabetic Subjects

2019 ◽  
Author(s):  
Brahm Prakash Guliani ◽  
Isha Agarwal ◽  
Mayuresh P. Naik
Keyword(s):  
Diabetic Retinopathy ◽  
Cataract Surgery ◽  
Normal Subjects ◽  
Early Postoperative Period ◽  
Macular Thickness ◽  
Central Macular Thickness ◽  
Significant Difference ◽  
The Mean ◽  
Group 2 ◽  
Group 1

Purpose: To assess the quantitative changes of macula in diabetic and non-diabetic eyes after uncomplicated cataract surgery. Methods: In this prospective interventional study being performed in a tertiary healthcare hospital, a total of 660 eyes were divided into two groups. Group 1 included 330 eyes from healthy subjects and group 2 included 330 eyes from well-controlled diabetic subjects with no diabetic retinopathy planned for phacoemulsification with foldable IOL implantation by the same surgeon under similar settings. Optical Coherence Tomography (Heidelberg Spectralis SD-OCT) was used to assess preoperative and postoperative central macular thickness (CMT) at weeks 1 and 6. Results: The mean CMT in group 1 preoperatively, at postoperative week 1, and at post-operative week 6 was 257.03 ± 20.904, 262.82 ± 17.010, and 265.15 ± 20.078 μm, respectively. The corresponding values in group 2 were 255.36 ± 17.852, 259.15 ± 16.644, and 266.09 ± 18.844 μm, respectively. There was no significant difference in the mean CMT values between the two groups on any of the three occasions when the CMT was measured (P = 0.374 and P = 0.313 at weeks 1 and 6, respectively). Conclusion: There was no statistically significant difference in CMT between normal subjects and diabetic subjects without diabetic retinopathy preoperatively and in early postoperative period after uncomplicated phacoemulsification surgery.

Transplantation of Bone Marrow Mesenchymal Stem Cells (BMSCs) Overexpressing Circular Zinc Finger Protein 609 Alleviates Diabetic Retinopathy

2021 ◽  
Vol 11 (12) ◽  
pp. 2497-2501
Author(s):  
Sheng Chen ◽  
Meiwen Tian ◽  
Shenwen Liu
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Diabetic Retinopathy ◽  
Rat Model ◽  
Zinc Finger Protein ◽  
Retinal Thickness ◽  
Vitreous Body ◽  
Macular Volume ◽  
Marrow Mesenchymal Stem Cells

Diabetic retinopathy (DR) is a chronic complications and its pathogenesis remains unclear. This study aims to elucidate the underlying mechanism by how bone marrow mesenchymal stem cells (BMSCs) affects DR development in a rat model. A rat model of DR was established and injected with BMSCs overexpressing Cir-ZNF609 and shRNA Cir-ZNF609 to vitreous body followed by analysis of the retinal vascular permeability and macular retinal layers thickness, and the levels of HIF-1α, ICAM-1 and VEGF in rat retina by ELISA and immunohistochemistry. Injection of BMSCs overexpressing Cir-ZNF609 resulted in decreased HIF-1α ICAM-1 and VEGF expression, amelioration of retinal ganglion choriocapillaris injury and reducing ganglion cells. Twelve weeks after treatment, neovascularization took place and fibroblasts appeared with some nucleus disappearing and pigment taking off. Besides, permeability also elevated in the presence of overexpressing Cir-ZNF609 and penetration rate for Evans blue (16.36+3.25, 15.45±3.46 μg/g) was lower than healthy rats (28.66±2.08, 32.24±4.36 μg/g) and controls (26.93±3.03, 33.49±5.02 μg/g) (p < 0.01). Moreover, upregulation of Cir-ZNF609 decreased retinal thickness and macular volume in DR rats (p < 0.05). In conclusion, intravitreal injection of mouse BMSCs overexpressing Cir-ZNF609 alleviates retinal injury and decreases retinal thickness and macular volume, and enhances neovascularization. These evidence provides a novel insight into gene therapy for DR.

scholarly journals Comparative study of optical coherence tomographic analysis of macula in preoperative and postoperative diabetic patients undergoing small incision cataract surgery

2021 ◽  
Vol 7 (2) ◽  
pp. 352-357
Author(s):  
Shruthi Marati ◽  
Vallabha K
Keyword(s):  
Diabetic Retinopathy ◽  
Cataract Surgery ◽  
Macular Edema ◽  
Macular Thickness ◽  
Diabetic Patients ◽  
Optical Coherence ◽  
Small Incision Cataract Surgery ◽  
Small Incision ◽  
Spectral Domain Oct ◽  
Quantitative Changes

The clinical evaluation of macular edema has been difficult to characterize, but evaluation has become more precise with the help of optical coherence tomography (OCT). This study is undertaken to evaluate the quantitative changes in macular thickness using spectral domain OCT in diabetic patients undergoing cataract surgery pre and post operatively and its relation with diabetic retinopathy (DR). Study participants included 65 diabetic patients irrespective of presence or absence of retinopathy who underwent cataract surgery. Each eye underwent fundus examination with indirect ophthalmoscopy and OCT of macula i.e.,preoperatively and at postoperatively at day 1, 1 week, 4 weeks and at 12 weeks. Best-corrected visual acuity (BCVA) was recorded at each visit. The central subfield macular thickness (CSMT) increased in all patients irrespective of presence or absence of diabetic retinopathy of about 17.4±25.3µm and 29µm±38.8 at 1 month and 3 month follow up. There was a statistically significant increase seen in CSMT after cataract surgery especially in patients with preoperatively diagnosed macular edema. Associated retinopathy also acts as a risk factor. But there was no statistically significant increase in mild and moderate NPDR preoperatively and also in postoperative period after uncomplicated small incision cataract surgery.

scholarly journals Detecting retinal neurodegeneration in people with diabetes: Findings from the UK Biobank

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257836
Author(s):  
Roomasa Channa ◽  
Kyungmoo Lee ◽  
Kristen A. Staggers ◽  
Nitish Mehta ◽  
Sidra Zafar ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Glycated Hemoglobin ◽  
Retinal Thickness ◽  
Self Report ◽  
Inner Plexiform Layer ◽  
Uk Biobank ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Retinal Neurodegeneration ◽  
The Uk

Importance Efforts are underway to incorporate retinal neurodegeneration in the diabetic retinopathy severity scale. However, there is no established measure to quantify diabetic retinal neurodegeneration (DRN). Objective We compared total retinal, macular retinal nerve fiber layer (mRNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness among participants with and without diabetes (DM) in a population-based cohort. Design/setting/participants Cross-sectional analysis, using the UK Biobank data resource. Separate general linear mixed models (GLMM) were created using DM and glycated hemoglobin as predictor variables for retinal thickness. Sub-analyses included comparing thickness measurements for patients with no/mild diabetic retinopathy (DR) and evaluating factors associated with retinal thickness in participants with and without diabetes. Factors found to be significantly associated with DM or thickness were included in a multiple GLMM. Exposure Diagnosis of DM was determined via self-report of diagnosis, medication use, DM-related complications or glycated hemoglobin level of ≥ 6.5%. Main outcomes and measures Total retinal, mRNFL and GC-IPL thickness. Results 74,422 participants (69,985 with no DM; 4,437 with DM) were included. Median age was 59 years, 46% were men and 92% were white. Participants with DM had lower total retinal thickness (-4.57 μm, 95% CI: -5.00, -4.14; p<0.001), GC-IPL thickness (-1.73 μm, 95% CI: -1.86, -1.59; p<0.001) and mRNFL thickness (-0.68 μm, 95% CI: -0.81, -0.54; p<0.001) compared to those without DM. After adjusting for co-variates, in the GLMM, total retinal thickness was 1.99 um lower (95% CI: -2.47, -1.50; p<0.001) and GC-IPL was 1.02 μm lower (95% CI: -1.18, -0.87; p<0.001) among those with DM compared to without. mRNFL was no longer significantly different (p = 0.369). GC-IPL remained significantly lower, after adjusting for co-variates, among those with DM compared to those without DM when including only participants with no/mild DR (-0.80 μm, 95% CI: -0.98, -0.62; p<0.001). Total retinal thickness decreased 0.40 μm (95% CI: -0.61, -0.20; p<0.001), mRNFL thickness increased 0.20 μm (95% CI: 0.14, 0.27; p<0.001) and GC-IPL decreased 0.26 μm (95% CI: -0.33, -0.20; p<0.001) per unit increase in A1c after adjusting for co-variates. Among participants with diabetes, age, DR grade, ethnicity, body mass index, glaucoma, spherical equivalent, and visual acuity were significantly associated with GC-IPL thickness. Conclusion GC-IPL was thinner among participants with DM, compared to without DM. This difference persisted after adjusting for confounding variables and when considering only those with no/mild DR. This confirms that GC-IPL thinning occurs early in DM and can serve as a useful marker of DRN.

scholarly journals Retina assessment by optical coherence tomography of diabetic dogs

2018 ◽  
Vol 38 (10) ◽  
pp. 1966-1971
Author(s):  
Michelle B.P. Braga-Sá ◽  
Paulo S.M. Barros ◽  
Juliana S. Jorge ◽  
Pamela Dongo ◽  
Paula Finkensieper ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Retinal Thickness ◽  
Statistical Significance ◽  
Endocrine Disorders ◽  
Optical Coherence ◽  
Ocular Manifestations ◽  
Diabetic Dogs ◽  
Large Vessels

ABSTRACT: Diabetes mellitus is one of the most common endocrine disorders characterized by relative or absolute lack of insulin; this can lead to several ocular manifestations, among them diabetic retinopathy and cataracts. Diabetic retinopathy (DR) is a microangiopathy that involves retinal precapillary arterioles, postcapillary venules, and large vessels, causing them to be functionally and anatomically incompetent. Hyperglycemia seems to be the most probable cause of damage to the retina due to interference in cellular metabolism and transduction processes. The aim of this study was to evaluate retinal thickness in eight diabetic dogs, four females and four males of different breeds and ages ranging from 6 to 15 years, by optical coherence tomography (OCT) and to compare them with non-diabetic dogs. Assessment provided by OCT in diabetic dogs showed retinal layers thinning and loss of stratification when compared to non-diabetic dogs (198μm versus 219μm respectively), with statistical significance (p=0.008). OCT images may suggest that diabetes mellitus causes retinal neuropathy in dogs, as also seen in diabetic humans.

scholarly journals Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis

Biomedicines ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. 190
Author(s):  
Ruby Kala Prakasam ◽  
Aleksandra Matuszewska-Iwanicka ◽  
Dagmar-Christiane Fischer ◽  
Heidrun Schumann ◽  
Diethelm Tschöpe ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Retinal Thickness ◽  
Early Stage ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Retinal Layers

Optical coherence tomography (OCT) supports the detection of thickness changes in intraretinal layers at an early stage of diabetes mellitus. However, the analysis of OCT data in cross-sectional studies is complex and time-consuming. We introduce an enhanced deviation map-based analysis (MA) and demonstrate its effectiveness in detecting early changes in intraretinal layer thickness in adults with type 2 diabetes mellitus (T2DM) compared to common early treatment diabetic retinopathy study (ETDRS) grid-based analysis (GA). To this end, we obtained OCT scans of unilateral eyes from 33 T2DM patients without diabetic retinopathy and 40 healthy controls. The patients were categorized according to concomitant diabetic peripheral neuropathy (DN). The results of MA and GA demonstrated statistically significant differences in retinal thickness between patients and controls. Thinning was most pronounced in total retinal thickness and the thickness of the inner retinal layers in areas of the inner macular ring, selectively extending into areas of the outer macular ring and foveal center. Patients with clinically proven DN showed the strongest thinning of the inner retinal layers. MA showed additional areas of thinning whereas GA tended to underestimate thickness changes, especially in areas with localized thinning. We conclude that MA enables a precise analysis of retinal thickness data and contributes to the understanding of localized changes in intraretinal layers in adults with T2DM.

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