scholarly journals Ultrastructural features and prevalence of tubuloreticular structures in the ocular vasculature of patients with AIDS: a study of 23 cases.

1996 ◽  
Vol 80 (3) ◽  
pp. 252-255 ◽  
Author(s):  
R K Maturi ◽  
R L Font
1976 ◽  
Vol 56 (3) ◽  
pp. 304-311 ◽  
Author(s):  
Satish Chandra ◽  
Stefano S. Stefani

Author(s):  
Gonzague S. Kistler ◽  
Peter Groscurth

Tubuloreticular structures (TRS) consisting of branching tubules of variable length and with a diameter of 18-30 nm have been described within dilated endoplasmic reticulum cisternae of endothelial and other cells in a variety of conditions. Thus, TRS have been observed in apparently normal human and animal cells, in cells of patients with auto-immune disease (e. g. systemic lupus erythematodes), with neoplasia (leukemias, carcinomas, sarcomas) as well as with a number of viral infections caused by both DNA or RNA viruses. Whereas earlier investigators regarded TRS as viral or virus-like in nature, it is now widely accepted that these structures represent focal proliferations of ER-membranes and that they reflect a cellular response to a broad range of stimuli. The biological significance of TRS has, however, not been resolved.In rubella-infected human embryos and fetuses, vascular lesions are the most frequently observed light microscopical findings.


1984 ◽  
Vol 34 (1) ◽  
pp. 1-9
Author(s):  
Hidekatsu Matsumura ◽  
Takao Setoguti ◽  
Kazuo Mori ◽  
Emanuel R. Ross ◽  
Atsuo Koto

1978 ◽  
Vol 34 (9) ◽  
pp. 1218-1219 ◽  
Author(s):  
A. P. Alves de Matos ◽  
R. Camara e Sousa

1999 ◽  
Vol 5 (S2) ◽  
pp. 1092-1093
Author(s):  
Gurdip S. Sidhu ◽  
Nicholas D. Cassai

TRS and CCC are endoplasmic reticulum membrane-derived structures seen in HIV-infected individuals in a variety of cell types. TRS (synonym: tubuloreticular inclusions) are 24-25 nm in diameter, branching tubules which are short or long and associated with the granular or smooth endoplasmic reticulum, the Golgi complex, the perinuclear cistern, and annulate lamellae (Fig. 1-3, 8). The tubules are noticeably more stretched out in Kaposi's sarcoma endothelial cells, presumably by an increase of matrix material within the reticulum sac (Fig. 3). TRS consist of membranous components, including polypeptides, but lack nucleic acid.CCC (test tube and ring-shaped forms; curvilinear membranes) are formed by a concentric stacking of two or three cisterns of endoplasmic reticulum resembling nuclear membrane in mitosis (Fig. 7), but with the interposition between the opposing membranes of a layer of electron-dense material that is resistant to lipid solvents (Fig. 4,5,8).


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