scholarly journals Ocular blood flow velocities in patients with proliferative diabetic retinopathy and healthy volunteers: a prospective study.

1995 ◽  
Vol 79 (5) ◽  
pp. 413-416 ◽  
Author(s):  
A Mendivil ◽  
V Cuartero ◽  
M P Mendivil
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Prospective Study ◽  
Healthy Volunteers ◽  
Proliferative Diabetic Retinopathy ◽  
Ocular Blood Flow ◽  
Blood Flow Velocities ◽  
A Prospective Study ◽  
Flow Velocities

Blood Flow Velocities in the Basal Cerebral Vein After Head Trauma: A Prospective Study in 82 Patients

2002 ◽  
Vol 12 (4) ◽  
pp. 325-329 ◽  
Author(s):  
Kay Mursch ◽  
Christian-Andreas Müller ◽  
Wolfgang Buhre ◽  
Johannes K. Lang ◽  
Hartmut Vatter ◽  
...  
Keyword(s):  
Blood Flow ◽  
Prospective Study ◽  
Head Trauma ◽  
Cerebral Vein ◽  
Blood Flow Velocities ◽  
A Prospective Study ◽  
Flow Velocities

The relation between cerebral blood flow velocities as measured by TCD and the incidence of delayed ischemic deficits. A prospective study after subarachnoid hemorrhage

2002 ◽  
Vol 24 (6) ◽  
pp. 582-592 ◽  
Author(s):  
Katarzyna Jarus-Dziedzic ◽  
Henryk Juniewicz ◽  
Jerzy Wroñski ◽  
Wojciech Leslaw Zub ◽  
Ekkehard Kasper ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Subarachnoid Hemorrhage ◽  
Prospective Study ◽  
Blood Flow Velocities ◽  
A Prospective Study ◽  
Flow Velocities

The Assessment of Blood Flow Velocities in Retinal Collaterals in Diabetic Retinopathy

2019 ◽  
Vol 236 (04) ◽  
pp. 530-535
Author(s):  
Gabor Somfai ◽  
Thalmon Campagnoli ◽  
Jing Tian ◽  
Heinrich Gerding ◽  
William Smiddy ◽  
...  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Microvascular Disease ◽  
Retinal Ischemia ◽  
Microvascular Changes ◽  
Significant Difference ◽  
Blood Flow Velocities ◽  
Collateral Vessels ◽  
Flow Velocities

Abstract Purpose Diabetic retinopathy (DR) is a microvascular disease characterized by capillary dropout and resultant retinal ischemia which then leads to retinal vascular remodeling. Our goal was to assess blood flow velocities in retinal collateral vessels in healthy and diabetic subjects with various stages of DR. Methods In our pilot study, we enrolled five eyes of five healthy subjects (H), five eyes of four subjects with diabetes and no retinopathy (DM), three eyes of three subjects with mild non-proliferative diabetic retinopathy (MDR), and five eyes of four subjects with proliferative diabetic retinopathy (PDR). Following routine ophthalmic examination, all subjects were imaged using a retinal function imager (RFI; Optical Imaging Inc., Rehovot, Israel). The built-in software of the RFI was used to identify and segment retinal collaterals with measurement of the blood flow velocities (BFV). One-way ANOVA was performed for BFV, followed by Newman-Keuls post hoc test. The level of significance was set at 5%. Results The total number of collateral segments involved in the study was 30, 31, 21, and 39 in the H, DM, MDR, and PDR groups, respectively. The BFVs in the collaterals were significantly lower in PDR (H: 1.86 ± 0.67, DM: 1.91 ± 0.71, MDR: 1.71 ± 0.53, PDR: 1.37 ± 0.58 mm/s). The PDR group showed a statistically significant difference in the comparisons to all groups (p = 0.012, p = 0.008, and p = 0.043 for the H, DM, and MDR groups, respectively), while no other comparisons between the groups were significant. Conclusion We observed decreased BFV in retinal collaterals in PDR that may be due to the extensive capillary dropout and retinal ischemia. Further studies are needed for the noninvasive functional assessment of retinal microvascular changes in DR to better understand the underlying pathophysiology.

scholarly journals Detection of significantly high vitreous concentrations of fatty acid-binding protein 4 in patients with proliferative diabetic retinopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kaku Itoh ◽  
Masato Furuhashi ◽  
Yosuke Ida ◽  
Hiroshi Ohguro ◽  
Megumi Watanabe ◽  
...  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Fatty Acid ◽  
Proliferative Diabetic Retinopathy ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Fatty Acid Binding ◽  
High Positive Correlation ◽  
Blood Biochemical

AbstractThe fatty acid-binding protein4 (FABP4) and vascular endothelial growth factor A (VEGFA) play key roles in the metabolic and cardiovascular diseases, and proliferative diabetic retinopathy (PDR), respectively. To identify FABP4 in vitreous fluid in PDR, vitreous concentrations of FABP4 (V-FABP4) and VEGFA (V-VEGFA) from PDR (n = 20) and non-PDR (n = 20) patients were determined by Enzyme-Linked ImmunoSorbent Assays. The data, which included height and weight, systemic blood pressures, several blood biochemical parameters and blood flow at the optic nerve head (ONH) by laser speckle flowgraphy (LSFG) were collected. The levels of V-FABP4 and V-VEGFA were significantly higher in PDR patients than in non-PDR patients (P < 0.001) with a high positive correlation (r = 0.72, P < 0.001) between them. The findings were not affected by body mass index values and the presence of vitreous hemorrhaging. Among the clinical parameters, V-FABP4 correlated positively with creatinine and negatively with age and aspartate transaminase (AST) levels, while V-VEGFA correlated positively with fasting plasma glucose and hemoglobin A1c (HbA1c) levels but negatively with AST. Multiple regression analyses indicated that V-VEGFA, or V-FABP4, AST and HbA1c were independent predictors of V-FABP4 or V-VEGFA, respectively. Both were negatively correlated, but more evident in V-FABP4, with the ONH ocular blood flow.

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