scholarly journals Infective conjunctivitis and corneal scarring in three brothers with sex linked hypogammaglobulinaemia (Bruton's disease).

1990 ◽  
Vol 74 (2) ◽  
pp. 118-120 ◽  
Author(s):  
T T Hansel ◽  
D P O'Neill ◽  
M L Yee ◽  
J M Gibson ◽  
R A Thompson
Keyword(s):  
Corneal Scarring ◽  
Bruton’S Disease

scholarly journals Visual and tear function improvement after superficial phototherapeutic keratectomy (PTK) for mid-stromal corneal scarring

Eye ◽  
2000 ◽  
Vol 14 (5) ◽  
pp. 779-784 ◽  
Author(s):  
Murat Dogru ◽  
Chikako Katakami ◽  
Masato Miyashita ◽  
Etsuko Hida ◽  
Mamoru Uenishi ◽  
...  
Keyword(s):  
Phototherapeutic Keratectomy ◽  
Corneal Scarring

Controlled thermocoagulation of trigeminal ganglion and rootlets for differential destruction of pain fibers

1974 ◽  
Vol 40 (2) ◽  
pp. 143-156 ◽  
Author(s):  
William H. Sweet ◽  
James G. Wepsic
Keyword(s):  
Trigeminal Neuralgia ◽  
Facial Pain ◽  
Electrical Heating ◽  
Gasserian Ganglion ◽  
Foramen Ovale ◽  
Content Type ◽  
Corneal Scarring ◽  
Radiofrequency Heating ◽  
Neurological Morbidity ◽  
Fine Print

✓ The authors report their experience in the treatment of trigeminal neuralgia with controlled increments of radiofrequency heating from an electrode placed in the Gasserian ganglion or its posterior rootlets. Touch is preserved in some or all of a trigeminal zone rendered analgesic. The electrode tip is introduced through the foramen ovale and placed among the desired rootlets with the help of a combination of radiographs and the conscious patient's response to electrical stimulation with a square wave signal and gentle electrical heating. The degree of heat is measured by a thermister at the electrode tip. The patient's cooperation is maintained by the use of the neurolept anesthetic Innovar and the production of brief unconsciousness for the painful parts of the operation by methohexital (Brevital). Of 274 patients with facial pain so treated, 214 had trigeminal neuralgia; 91% of the latter group experienced relief of pain and 125 followed for 2½ to 6 years had a recurrence rate of 22%. In a total of 353 procedures, there has been no mortality and no neurological morbidity outside the trigeminal nerve. Only six of the patients with trigeminal neuralgia have complained significantly of postoperative paresthesias. The most serious undesired result has been the production of an anesthetic cornea in 28 patients, one of whom lost the sight of one eye due to corneal scarring. Correlating findings in our patients with those in studies by other authors, we conclude that the preservation of some touch is due to resistance to heating by the heavily myelinated A-beta fibers.

scholarly journals Circinate corneal scarring

2004 ◽  
Vol 87 (1) ◽  
pp. 28-33
Author(s):  
Sandra Coulson BOptom ◽  
Adrian Bruce
Keyword(s):  
Corneal Scarring

HSV-1 small non-coding RNA (sncRNA) 1 and 2 activate the Herpes virus entry mediator (HVEM) promoter

2021 ◽  
Author(s):  
Kati Tormanen ◽  
Shaohui Wang ◽  
Harry H. Matundan ◽  
Jack Yu ◽  
Ujjaldeep Jaggi ◽  
...  
Keyword(s):  
Binding Sites ◽  
Promoter Activity ◽  
Start Codon ◽  
Type I ◽  
Rna Molecules ◽  
Corneal Scarring ◽  
Non Coding Rna ◽  
Interferon Pathway ◽  
Antiapoptotic Activity ◽  
Hsv 1

HSV-1 latency associated transcript (LAT) plays a significant role in efficient establishment of latency and reactivation. LAT has antiapoptotic activity and downregulates expression of components of the Type I interferon pathway. LAT also specifically activates expression of the herpesvirus entry mediator (HVEM), one of seven known receptors used by HSV-1 for cell entry that is crucial for latency and reactivation. However, the mechanism by which LAT regulates HVEM expression is not known. LAT encodes two sncRNAs that are not miRNAs, within its 1.5 kb stable transcript, which also have antiapoptotic activity. These sncRNAs may encode short peptides, but experimental evidence is lacking. Here, we demonstrate that these two sncRNAs control HVEM expression by activating its promoter. Both sncRNAs are required for WT level of activation of HVEM and sncRNA1 is more important in HVEM activation than sncRNA2. Disruption of a putative start codon in sncRNA1 and sncRNA2 sequences reduced HVEM promoter activity, suggesting that sncRNAs may encode a protein. However, we did not detect peptide binding using two chromatin immunoprecipitation (ChIP) approaches and a web-based algorithm predicts low probability that the putative peptides bind to DNA. In addition, computational modeling predicts that sncRNA molecules bind with high affinity to the HVEM promoter and deletion of these binding sites to sncRNA1, sncRNA2 or both reduced HVEM promoter activity. Together, our data suggests that sncRNAs exert their function as RNA molecules, not as proteins, and we provide a model for the predicted binding affinities and binding sites of sncRNA1 and sncRNA2 in the HVEM promoter. IMPORTANCE HSV-1 causes recurrent ocular infections, which is the leading cause of corneal scarring and blindness. Corneal scarring is caused by the host immune response to repeated reactivation events. LAT functions by regulating latency and reactivation, in part by inhibiting apoptosis and activating HVEM expression. However, the mechanism used by LAT to control of HVEM expression is unclear. Here, we demonstrate that two sncRNAs encoded within the 1.5 kb LAT transcript activate HVEM expression by binding to two regions of its promoter. Interfering with these interactions may reduce latency and thereby eye disease associated with reactivation.

Increased Corneal Scarring after Phototherapeutic Keratectomy in Fuchs' Corneal Dystrophy

1997 ◽  
Vol 13 (3) ◽  
pp. 308-310
Author(s):  
Mohammed Alaa ◽  
George O Waring ◽  
Amin Malaty ◽  
Hans Grossniklaus
Keyword(s):  
Corneal Dystrophy ◽  
Phototherapeutic Keratectomy ◽  
Corneal Scarring

Penetrating Keratoplasty in Patients With Corneal Scarring Due to Trachoma

1999 ◽  
Vol 30 (9) ◽  
pp. 734-741
Author(s):  
Inci Kocak-Midillioglu ◽  
Yonca Aydin Akova ◽  
Ayse Gul Koçak-Altintas ◽  
Bekir S Aslan ◽  
Sunay Duman
Keyword(s):  
Penetrating Keratoplasty ◽  
Corneal Scarring

scholarly journals Significant Inhibition of Corneal Scarring In Vivo with Tissue-Selective, Targeted AAV5 Decorin Gene Therapy

2011 ◽  
Vol 52 (7) ◽  
pp. 4833 ◽  
Author(s):  
Rajiv R. Mohan ◽  
Ashish Tandon ◽  
Ajay Sharma ◽  
John W. Cowden ◽  
Jonathan C. K. Tovey
Keyword(s):  
Gene Therapy ◽  
Significant Inhibition ◽  
Corneal Scarring

scholarly journals Diamond burr superficial keratectomy with mitomycin C for corneal scarring and high corneal astigmatism after pterygium excision

2013 ◽  
pp. 951 ◽  
Author(s):  
Engin Bilge Ozgurhan ◽  
Necip Kara ◽  
Aydin Yildirim ◽  
Ercüment Bozkurt ◽  
Demirok ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Corneal Astigmatism ◽  
Corneal Scarring ◽  
Diamond Burr ◽  
Pterygium Excision

Corneal Scarring and Vision in Keratoconus

Cornea ◽  
2000 ◽  
Vol 19 (6) ◽  
pp. 804-812 ◽  
Author(s):  
Karla Zadnik ◽  
Joseph T. Barr ◽  
Timothy B. Edrington ◽  
Jason J. Nichols ◽  
Brad S. Wilson ◽  
...  
Keyword(s):  
Corneal Scarring
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