scholarly journals Induced corneal opacities in the rat.

1967 ◽  
Vol 51 (2) ◽  
pp. 124-129 ◽  
Author(s):  
R J Fabian ◽  
J M Bond ◽  
H P Drobeck
Keyword(s):  
Corneal Opacities

The technique of one-piece mushroom keratoplasty for stromal corneal opacities

2020 ◽  
pp. 62-63
Author(s):  
E.A. Budnikova ◽  
◽  
S.V. Trufanov ◽  
A.V. Zaitsev ◽  
M.A. Makarova ◽  
...  
Keyword(s):  
Corneal Opacities

PRE‐NATAL CORNEAL OPACITIES

1915 ◽  
Vol 1 (1) ◽  
pp. 8-8
Author(s):  
James M. Baxter
Keyword(s):  
Corneal Opacities

scholarly journals Diagnosing Paraproteinemic Keratopathy: A Case Report

2021 ◽  
pp. 337-343
Author(s):  
Eugenie Mok ◽  
Ka Wai Kam ◽  
Anthony J. Aldave ◽  
Alvin L. Young
Keyword(s):  
Optical Coherence Tomography ◽  
Genetic Testing ◽  
Serum Protein ◽  
Molecular Genetic ◽  
Anterior Segment ◽  
Protein Electrophoresis ◽  
Serum Protein Electrophoresis ◽  
Optical Coherence ◽  
Molecular Genetic Testing ◽  
Corneal Opacities

A 65-year-old man presented with bilateral, painless, progressive blurring of vision over 9 years. Slit-lamp examination revealed bilateral subepithelial corneal opacities in clusters located at the mid-periphery. Anterior segment optical coherence tomography, in vivo confocal microscopy (IVCM), serum protein electrophoresis, and molecular genetic testing were performed to evaluate the cause of corneal opacities. Anterior segment optical coherence tomography revealed a band-like, hyperreflective lesion in the Bowman layer and anterior stroma of both corneas. IVCM revealed hyperreflective deposits in the epithelium, anterior stroma, and endothelium. Serum protein electrophoresis identified the presence of paraproteins (immunoglobulin kappa), and molecular genetic testing revealed absence of mutations in the transforming growth factor beta-induced gene (<i>TGFBI</i>) and collagen type XVII alpha 1 gene (<i>COL17A1</i>). The ocular diagnosis of paraproteinemic keratopathy eventually led to a systemic diagnosis of monoclonal gammopathy of undetermined significance by our hematologist/oncologist. Paraproteinemic keratopathy is a rare differential diagnosis in patients with bilateral corneal opacities and therefore may be misdiagnosed as corneal dystrophy or neglected as scars. In patients with bilateral corneal opacities of unknown cause, serological examination, adjunct anterior segment imaging, and molecular genetic testing play a role in establishing the diagnosis.

The Use of an Opacitometer to Compare the In Vitro Cornea Opacifying Effects of Timolol With and Without Benzalkonium Chloride

1991 ◽  
Vol 19 (2) ◽  
pp. 263-270
Author(s):  
Haruyoshi Igarashi ◽  
Yasunaga Katsuta ◽  
Yoshiharu Nakazato ◽  
Tohru Kawasaki
Keyword(s):  
Benzalkonium Chloride ◽  
Additive Effects ◽  
Timolol Maleate ◽  
Epithelial Surface ◽  
Endothelial Surface ◽  
Draize Test ◽  
Corneal Opacities

We have evaluated a new in vitro opacitometer method as an alternative to the in vivo Draize test for ocular irritancy. Several concentrations of timolol maleate (timolol) with or without 0.005% benzalkonium chloride were applied to porcine isolated corneas which were either intact or with the epithelium, endothelium, or both epithelium and endothelium removed. Corneal opacities were measured using an opacitometer. In general, timolol with benzalkonium chloride caused a greater degree of opacity to develop in the cornea than did timolol alone. At the lower concentrations of timolol, the increased opacity probably represented additive effects of the two compounds. However, at the highest concentration of timolol (5 x 10 2M), there was an enhanced opacification in the presence of benzalkonium chloride, which may have been due to an increase in penetration, particularly through the epithelium. Timolol caused a greater degree of opacity to develop in the isolated intact porcine corneas when the drug was applied to the endothelial surface, than when applied to the epithelial surface or to both the epithelial and endothelial surfaces. However, timolol with benzalkonium chloride caused a greater degree of opacity in the intact cornea, when the drug was applied to both surfaces than when it was applied only to the epithelial or the endothelial surface.

Novel Lamellar, Flap-Based Tattooing Techniques for Corneal Opacities in Scarred and Vascularized Blind Eyes

Cornea ◽  
2015 ◽  
Vol 34 (1) ◽  
pp. 82-86 ◽  
Author(s):  
Deniz Hos ◽  
Ludwig M. Heindl ◽  
Franziska Bucher ◽  
Claus Cursiefen
Keyword(s):  
Corneal Opacities

Overview of Congenital Corneal Opacities: Clinical Diagnosis, Treatment, and Prognosis

2021 ◽  
Vol 62 (1) ◽  
pp. 1-13
Author(s):  
Abdelrahman M. Elhusseiny ◽  
Omar Solyman ◽  
Shazia F. Ali
Keyword(s):  
Clinical Diagnosis ◽  
Corneal Opacities

Visual System Screening in Infants and Young Children

1982 ◽  
Vol 4 (3) ◽  
pp. 71-73
Author(s):  
J. Allen Gammon
Keyword(s):  
Young Children ◽  
Visual System ◽  
Early Recognition ◽  
Visual Development ◽  
Congenital Glaucoma ◽  
Laboratory Animals ◽  
Congenital Cataracts ◽  
Ocular Abnormalities ◽  
Corneal Opacities ◽  
Infants And Young Children

Many abnormalities of the visual system in infants and young children respond to treatment when instituted at an early age. Ocular abnormalities that require early recognition and therapy include congenital cataracts, congenital glaucoma, intraocular tumors, intraocular inflammation, large errors of refraction, strabismus, and corneal opacities (Figs 1 to 6). The visual prognosis for children with these problems is often directly related to early detection and treatment of the visual disorder. Visual deprivation of young laboratory animals can permanently damage their developing central nervous system. Diseases once believed hopeless, such as monocular congenital cataracts, can now be treated.1 Technologic advances, such as extended-wear contact lenses which are useful for infants who have had cataract surgery during the first few weeks of life, have facilitated visual rehabilitation of young eyes. Corneal opacities, complete ptosis, prolonged patching, and eyelid or orbit abnormalities such as large hemangiomas can cause amblyopia if the vision is obstructed. Even brief occlusion can result in irreversible amblyopia during the early months of life.2 Unilateral disruptions of vision are generally more damaging to the eye than are bilateral ocular abnormalities. Each of the young child's eyes must enjoy a clear, focused retinal image for visual development to progress normally. Early diagnosis and treatment of congenital glaucoma is important so that intraocular pressure can be lowered, thereby, avoiding irreversible anatomic damage to the eye.

scholarly journals Prevalence of visual impairment and eye diseases in Afghan refugees in Pakistan

1998 ◽  
Vol 4 (3) ◽  
pp. 560-566
Author(s):  
H. R. Awan ◽  
T. Ihsan
Keyword(s):  
Visual Loss ◽  
Eye Diseases ◽  
Refractive Errors ◽  
Northern Pakistan ◽  
Active Trachoma ◽  
Who Criteria ◽  
Afghan Refugees ◽  
Refugee Community ◽  
Afghan Refugee ◽  
Corneal Opacities

The prevalence and etiology of visual loss and eye diseases were determined in a resident Afghan refugee community in northern Pakistan. The survey included 1156 people and revealed that 2.1% of the population were blind and 6.9% were visually impaired according to WHO criteria. The leading causes of blindness included cataract [62.5%], uncorrected refractive errors [16.6%], retinal degeneration/dystrophy [12.5%], glaucoma [4.2%] and microphthalmos [4.2%]. The causes of visual loss were uncorrected refractive errors [46.2%], cataract [32.7%] and corneal opacities [4.8%]. These conditions were also important causes of unilateral lost vision. Active trachoma was found in 3.7% of all children under 10 years of age

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