Immunohistochemical localisation of intravitreally injected bevacizumab in the anterior chamber angle, iris and ciliary body of the primate eye

2008 ◽  
Vol 92 (4) ◽  
pp. 541-544 ◽  
Author(s):  
S Peters ◽  
P Heiduschka ◽  
S Julien ◽  
K-U Bartz-Schmidt ◽  
U Schraermeyer
Keyword(s):  
Anterior Chamber ◽  
Ciliary Body ◽  
Anterior Chamber Angle ◽  
Chamber Angle

Anterior Chamber Angle and Iris-Lens Contact Alteration During Pupillary Dilation

2011 ◽  
Author(s):  
Sara Jouzdani ◽  
Rouzbeh Amini ◽  
Victor H. Barocas
Keyword(s):  
Intraocular Pressure ◽  
Anterior Chamber ◽  
Aqueous Humor ◽  
Ciliary Body ◽  
Ocular Tissue ◽  
Posterior Chamber ◽  
Pupillary Dilation ◽  
Anterior Chamber Angle ◽  
Aqueous Outflow ◽  
Chamber Angle

The aqueous humor (AH) provides oxygen and nutrients for the avascular ocular tissue specifically, the cornea and lens. AH is secreted by the ciliary body into the posterior chamber, passes through pupil, and drains into the anterior chamber (Fig. 1a). Resistance to the aqueous outflow generates the intraocular pressure (IOP), which is 15–20 mmHg in the normal eyes.

scholarly journals Penetration of Bevacizumab into the Iris, Anterior Chamber Angle and Ciliary Body After Intravitreal Injection

2009 ◽  
Vol 03 (01) ◽  
pp. 36
Author(s):  
Swaantje Peters ◽  
Peter Heiduschka ◽  
Karl-Ulrich Bartz-Schmidt ◽  
Ulrich Schraermeyer ◽  
◽  
...  
Keyword(s):  
Anterior Chamber ◽  
Intravitreal Injection ◽  
Ciliary Body ◽  
Anterior Segment ◽  
Intravitreal Bevacizumab ◽  
Neovascular Glaucoma ◽  
Anterior Chamber Angle ◽  
Rubeosis Iridis ◽  
Endothelial Growth Factor ◽  
Chamber Angle

Recently, it was suggested that the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab could be used in the treatment of rubeosis iridis. Therefore, we aimed to trace the penetration of bevacizumab into the anterior chamber after intravitreal injection of the drug. We found that intravitreally injected bevacizumab penetrates well and quickly into the anterior chamber angle, iris and ciliary body. The highest concentration of bevacizumab is present on days one to four after injection, with penetration into the iris appearing to be faster than that into the anterior chamber angle and ciliary body. These findings are consistent with the clinically described regression of iris neovascularisation one to three days after injection. Furthermore, we demonstrated progressive penetration through the tissues of the anterior chamber towards the sclera. Our study showed that the intravitreal application mode is suitable for obtaining an accumulation of bevacizumab throughout the vascularised tissues of the anterior segment. Intravitreal bevacizumab may be used as a supplementary treatment for rubeosis iridis and neovascular glaucoma.

Glaucoma Problems Associated with Aniridia

2010 ◽  
Author(s):  
Peter A. Netland
Keyword(s):  
Intraocular Pressure ◽  
Anterior Chamber ◽  
Trabecular Meshwork ◽  
Ciliary Body ◽  
Vision Loss ◽  
Visual Field Loss ◽  
Anterior Chamber Angle ◽  
Foveal Hypoplasia ◽  
Closed Angle ◽  
Chamber Angle

Glaucoma is a potentially vision-threatening problem that is commonly encountered in aniridia patients. This condition may develop at birth, or shortly thereafter. More commonly, however, glaucoma is acquired later in childhood or even young adulthood. If unrecognized and untreated, glaucoma can result in blindness. For this reason, it is important to be vigilant in watching for this condition in children affected with aniridia. Vision lost due to glaucomatous damage cannot be regained at a later time. In addition to glaucoma, children with aniridia may demonstrate other problems with their vision. They may have refractive errors, corneal or retinal problems, or abnormalities of eye movement. Foveal hypoplasia (lack of development of the retina) may limit vision in some children. In aniridia patients, cataract (opacification or cloudiness of the lens) is seen with approximately the same prevalence as glaucoma. Cataract, however, differs from glaucoma in that the vision loss due to cataract is reversible. Glaucoma is suspected in aniridia patients when there is an increased intraocular pressure. Glaucoma can be definitely diagnosed when changes of the optic nerve occur due to this elevated intraocular pressure. At the later stages of the disease, visual field loss occurs. In the normal eye, the fluid (aqueous humor) in the front of the eye (the anterior chamber) is produced by the ciliary body, which is located behind the iris (see Figure 5.1). The fluid produced from the ciliary body flows forward into the anterior chamber, where it drains from the anterior chamber angle through tissue called the trabecular meshwork. When there is an abnormal situation, the fluid exits the eye poorly or not at all, and the intraocular pressure may be increased. The fluid may be blocked from exiting the eye by a closed angle, or may flow poorly out of the eye even though the angle is open (see Figure 5.2). The angle may be closed in aniridic patients when the stump of residual iris covers the trabecular meshwork in the anterior chamber angle.

Ciliary Body and Iris Metastases With Anterior Chamber Angle Infiltration

2020 ◽  
Vol 29 (3) ◽  
pp. e12-e15
Author(s):  
Andrew J. Swampillai ◽  
Adam P. Booth ◽  
Victoria M.L. Cohen
Keyword(s):  
Anterior Chamber ◽  
Ciliary Body ◽  
Anterior Chamber Angle ◽  
Chamber Angle
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