scholarly journals Localisation of SDF-1 and its receptor CXCR4 in retina and choroid of aged human eyes and in eyes with age related macular degeneration

2006 ◽  
Vol 90 (7) ◽  
pp. 906-910 ◽  
Author(s):  
I A Bhutto ◽  
D S McLeod ◽  
C Merges ◽  
T Hasegawa ◽  
G A Lutty
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Human Eyes

scholarly journals Fibulin-5 distribution in human eyes: Relevance to age-related macular degeneration

2007 ◽  
Vol 84 (2) ◽  
pp. 378-380 ◽  
Author(s):  
Robert F. Mullins ◽  
Marissa A. Olvera ◽  
Abbot F. Clark ◽  
Edwin M. Stone
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Human Eyes

scholarly journals Fructosamine-3-Kinase as a Potential Treatment Option for Age-Related Macular Degeneration

2020 ◽  
Vol 9 (9) ◽  
pp. 2869
Author(s):  
Sander De Bruyne ◽  
Caroline Van den Broecke ◽  
Henk Vrielinck ◽  
Samira Khelifi ◽  
Olivier De Wever ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Near Infrared ◽  
Ex Vivo ◽  
Pairwise Comparison ◽  
Age Related Macular Degeneration ◽  
Tissue Sections ◽  
Age Related ◽  
Human Eyes ◽  
Developed World ◽  
First Time

Age-related macular degeneration is the leading cause of blindness in the developed world. Since advanced glycation end products (AGEs) are implicated in the pathogenesis of AMD through various lines of evidence, we investigated the potential of fructosamine-3-kinase (FN3K) in the disruption of retinal AGEs, drusenoid material and drusenoid lesions in patients with AMD. AGE-type autofluorescence was measured to evaluate the effects of FN3K on glycolaldehyde-induced AGE-modified neural porcine retinas and unmodified human neural retinas. Eye pairs from cigarette-smoke- and air-exposed mice were treated and evaluated histologically. Automated optical image analysis of human tissue sections was performed to compare control- and FN3K-treated drusen and near-infrared (NIR) microspectroscopy was performed to examine biochemical differences. Optical coherence tomography (OCT) was used to evaluate the effect of FN3K on drusenoid deposits after treatment of post-mortem human eyes. FN3K treatment provoked a significant decrease (41%) of AGE-related autofluorescence in the AGE-modified porcine retinas. Furthermore, treatment of human neural retinas resulted in significant decreases of autofluorescence (−24%). FN3K-treated murine eyes showed less drusenoid material. Pairwise comparison of drusen on tissue sections revealed significant changes in color intensity after FN3K treatment. NIR microspectroscopy uncovered clear spectral differences in drusenoid material (Bruch’s membrane) and drusen after FN3K treatment. Ex vivo treatment strongly reduced size of subretinal drusenoid lesions on OCT imaging (up to 83%). In conclusion, our study demonstrated for the first time a potential role of FN3K in the disruption of AGE-related retinal autofluorescence, drusenoid material and drusenoid lesions in patients with AMD.

Elemental concentrations in Choroid-RPE and retina of human eyes with age-related macular degeneration

2019 ◽  
Vol 186 ◽  
pp. 107718 ◽  
Author(s):  
Seeneevasan Aberami ◽  
Sampath Nikhalashree ◽  
Muthuvel Bharathselvi ◽  
Jyotirmay Biswas ◽  
Konerirajapuram Natarajan Sulochana ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Elemental Concentrations ◽  
Age Related ◽  
Human Eyes

scholarly journals Choriocapillaris Vascular Dropout Related to Density of Drusen in Human Eyes with Early Age-Related Macular Degeneration

2011 ◽  
Vol 52 (3) ◽  
pp. 1606 ◽  
Author(s):  
Robert F. Mullins ◽  
Micaela N. Johnson ◽  
Elizabeth A. Faidley ◽  
Jessica M. Skeie ◽  
Jian Huang
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Early Age ◽  
Age Related ◽  
Human Eyes

scholarly journals Localization of complement 1 inhibitor (C1INH/SERPING1) in human eyes with age-related macular degeneration

2009 ◽  
Vol 89 (5) ◽  
pp. 767-773 ◽  
Author(s):  
Robert F. Mullins ◽  
Elizabeth A. Faidley ◽  
Heather T. Daggett ◽  
Catherine Jomary ◽  
Andrew J. Lotery ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Human Eyes

scholarly journals Distribution and Quantification of Choroidal Macrophages in Human Eyes With Age-Related Macular Degeneration

2016 ◽  
Vol 57 (14) ◽  
pp. 5843 ◽  
Author(s):  
D. Scott McLeod ◽  
Imran Bhutto ◽  
Malia M. Edwards ◽  
Rachel E. Silver ◽  
Johanna M. Seddon ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Human Eyes

scholarly journals Ex Vivo Hyperspectral Autofluorescence Imaging and Localization of Fluorophores in Human Eyes with Age-Related Macular Degeneration

Vision ◽  
2018 ◽  
Vol 2 (4) ◽  
pp. 38
Author(s):  
Taariq Mohammed ◽  
Yuehong Tong ◽  
Julia Agee ◽  
Nayanika Challa ◽  
Rainer Heintzmann ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Ex Vivo ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Emission Spectra ◽  
Age Related Macular Degeneration ◽  
Autofluorescence Imaging ◽  
Age Related ◽  
Human Eyes ◽  
Similar Peak

To characterize fluorophore signals from drusen and retinal pigment epithelium (RPE) and their changes in age related macular degeneration (AMD), the authors describe advances in ex vivo hyperspectral autofluorescence (AF) imaging of human eye tissue. Ten RPE flatmounts from eyes with AMD and 10 from eyes without AMD underwent 40× hyperspectral AF microscopic imaging. The number of excitation wavelengths tested was initially two (436 nm and 480 nm), then increased to three (436 nm, 480 nm, and 505 nm). Emission spectra were collected at 10 nm intervals from 420 nm to 720 nm. Non-negative matrix factorization (NMF) algorithms decomposed the hyperspectral images into individual emission spectra and their spatial abundances. These include three distinguishable spectra for RPE fluorophores (S1, S2, and S3) in both AMD and non-AMD eyes, a spectrum for drusen (SDr) only in AMD eyes, and a Bruch’s membrane spectrum that was detectable in normal eyes. Simultaneous analysis of datacubes excited atthree excitation wavelengths revealed more detailed spatial localization of the RPE spectra and SDr within drusen than exciting only at two wavelengths. Within AMD and non-AMD groups, two different NMF initialization methods were tested on each group and converged to qualitatively similar spectra. In AMD, the peaks of the SDr at ~510 nm (436 nm excitation) were particularly consistent. Between AMD and non-AMD groups, corresponding spectra in common, S1, S2, and S3, also had similar peak locations and shapes, but with some differences and further characterization warranted.

Age related macular degeneration (ARMD) – pathophysiological and clinical features and therapeutic concepts

2001 ◽  
Vol 58 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Ursula Körner-Stiefbold
Keyword(s):  
Macular Degeneration ◽  
Clinical Features ◽  
Altersbedingte Makuladegeneration ◽  
Age Related Macular Degeneration ◽  
Genetische Faktoren ◽  
Age Related ◽  
Therapeutic Concepts

Die altersbedingte Makuladegeneration (AMD) ist eine der häufigsten Ursachen für einen irreversiblen Visusverlust bei Patienten über 65 Jahre. Nahezu 30% der über 75-Jährigen sind von einer AMD betroffen. Trotz neuer Erkenntnisse in der Grundlagenforschung ist die Ätiologie, zu der auch genetische Faktoren gehören, noch nicht völlig geklärt. Aus diesem Grund sind die Behandlungsmöglichkeiten zum jetzigen Zeitpunkt noch limitiert, so dass man lediglich von Therapieansätzen sprechen kann. Die derzeit zur Verfügung stehenden Möglichkeiten wie medikamentöse, chirurgische und laser- und strahlentherapeutische Maßnahmen werden beschrieben.

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