scholarly journals Unilateral necrotising toxoplasmic retinochoroiditis as the main clinical manifestation of a peptide transporter (TAP) deficiency

2005 ◽  
Vol 89 (12) ◽  
pp. 1661-1662 ◽  
Author(s):  
A Parissiadis
Keyword(s):  
Clinical Manifestation ◽  
Peptide Transporter ◽  
Toxoplasmic Retinochoroiditis ◽  
Main Clinical Manifestation

scholarly journals Enteropathy with impaired membrane digestion and the prospects for cytoprotective therapy

2021 ◽  
Vol 93 (2) ◽  
pp. 129-137
Author(s):  
A. I. Parfenov ◽  
O. V. Akhmadullina ◽  
N. I. Belostotsky ◽  
E. A. Sabelnikova ◽  
A. A. Novikov ◽  
...  
Keyword(s):  
Small Intestine ◽  
Mucous Membrane ◽  
Clinical Manifestation ◽  
Clinical Picture ◽  
Food Products ◽  
The Poor ◽  
Intestinal Infections ◽  
Poor Tolerance ◽  
Carbohydrate Intolerance ◽  
Main Clinical Manifestation

The article describes enteropathy with impaired membrane digestion (EIMD) as a new nosological form. The main clinical manifestation of EIMD is the poor tolerance of food products, in particular carbohydrates and a decrease in the activity of membrane enzymes, in particular, carbohydrates, in the mucous membrane of the small intestine. The cause of the disease can be acute intestinal infections, viruses, drugs and other agents that damage the small intestine. The pathophysiology, clinical picture and diagnosis of EIMD are described. The basis of therapy is rebamipide, which has the ability to reduce the symptoms of carbohydrate intolerance and increase the activity of disaccharidases.

FEATURES OF THE CLINICAL COURSE OF MEMBRANOUS NEPHROPATHY

Vestnik ◽  
2021 ◽  
pp. 155-157
Author(s):  
Л.П. Мамедова ◽  
А.К. Беисбекова
Keyword(s):  
Nephrotic Syndrome ◽  
Clinical Manifestation ◽  
Immune Complexes ◽  
Membranous Nephropathy ◽  
Clinical Course ◽  
The Body ◽  
High Cholesterol ◽  
Vascular Walls ◽  
Progressive Stage ◽  
Main Clinical Manifestation

Мембранозная нефропатия является иммунологически обусловленной не воспалительной гломерулопатией, имеет прогрессирующее стадийное течение и характеризуется дистрофическими и склеротическими процессами. Мембранозная нефропатия - это поражение почечных клубочков (основные функциональные единицы почек), возникающее вследствие оседания на стенках почечных капилляров иммунных комплексов. Это приводит к утолщению и дальнейшему расслоению базальных мембран и стенок сосудов в клубочках. Основным клиническим проявлением МН является нефротический синдром (отеки по всему телу, наличие белка в моче и высокий холестерин в крови). Membranous nephropathy is an immunologically determined non-inflammatory glomerulopathy, has a progressive stage course and is characterized by dystrophic and sclerotic processes. Membranous nephropathy is a lesion of the renal glomeruli (the main functional units of the kidneys) that occurs due to the settling of immune complexes on the walls of the renal capillaries. This leads to thickening and further delamination of the basal membranes and vascular walls in the glomeruli. The main clinical manifestation of MN is nephrotic syndrome (edema throughout the body, the presence of protein in the urine and high cholesterol in the blood).

Cranial Nerve-VI Palsy as the Main Clinical Manifestation of Neurosarcoidosis

2016 ◽  
Vol 21 (6) ◽  
pp. 109-111 ◽  
Author(s):  
Zaid A. Al-Qudah ◽  
Hussam A. Yacoub ◽  
Nizar Souayah
Keyword(s):  
Clinical Manifestation ◽  
Cranial Nerve ◽  
Main Clinical Manifestation

scholarly journals Acute myocarditis as the main clinical manifestation of SARS-CoV 2 infection: A case report

2020 ◽  
Vol 12 (2) ◽  
Author(s):  
Gianluca Cuomo ◽  
Marianna Menozzi ◽  
Federica Carli ◽  
Margherita Digaetano ◽  
Alessandro Raimondi ◽  
...  
Keyword(s):  
Case Report ◽  
Clinical Manifestation ◽  
Cardiac Mri ◽  
Laboratory Tests ◽  
Acute Myocarditis ◽  
Favorable Outcome ◽  
Immunological Pathogenesis ◽  
Main Clinical Manifestation ◽  
The Way

We describe a case of acute myocarditis which was reported as the main COVID-19 clinical manifes-tation, with a favorable outcome. In addition to symptoms, laboratory tests (BNP and troponin), echo-cardiogram and cardiac MRI contributed to diagnosis. Regardless heart biopsy was not obtained, it is likely an immunological pathogenesis of this condition which pave the way to further therapeutic im-plications, since there are currently no standardized treatments.

scholarly journals Multiple endocrine neoplasia syndrome

2021 ◽  
Vol 29 (2) ◽  
pp. 150-158
Author(s):  
М. V. Krasnoselskyi ◽  
А. V. Svynarenko ◽  
N. S. Pidchenko ◽  
A. S. Simbirоva
Keyword(s):  
Radiation Therapy ◽  
Clinical Manifestation ◽  
Multiple Endocrine Neoplasia ◽  
Type I ◽  
Reliable Control ◽  
Endocrine Neoplasia ◽  
Pancreatic Insulinoma ◽  
Multiple Endocrine Neoplasia Syndrome ◽  
Remote Radiation ◽  
Main Clinical Manifestation

Background. Multiple endocrine neoplasia type 1 is a rare inherited disease that combines heterogeneous autosomal inherited disorders, the pathogenesis of which is based on hyperplasia or tumor transformation of several neuro- endocrine glands. In this pathology, treatment protocols are insufficient. Surgical treatment, suppressive or replacement therapy, radiation and chemotherapy are mainly used. We presented a successful experience of combined radiotherapy of multiple pancreatic insulinoma as the main clinical manifestation of the syndrome of multiple endocrine neoplasia. The combination of intra-tissue brachytherapy and megavolt remote therapy in TFD, isoeffective 50 Gy, allowed to achieve reliable control of hypoglycemic attacks within 2 years of follow-up. Purpose – to acquaint the medical community with successful experience of combined radiation treatment of multiple pancreatic insulinoma as a main clinical manifestation of the multiple endocrine neoplasia syndrome. Materials and Methods. Clinical case of patient L., 30 years old, who received combined radiation therapy for clinically significant manifestations of hormonally active multiple insulinoma of the pancreas in the Department of Radiological Oncology of State Organization «Grigoriev Institute for Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine». Results. In May 2019, palliative contact brachytherapy was performed on the MULTISOURCE device. Total focal dose (TFD) for cells in the pancreas GENUS 3 Gy 5 times a week, TFD 18 Gy. At the end of brachytherapy, attacks of hypoclycemia were stopped. In March 2020, remote radiation therapy was performed on a linear accelerator CLINAC-600C (6MeV) in the mode of classical fractionation (single focal dose (SFD) 1.8 Gy 5 times a week), TFD for the entire volume of the pancreas 30.6 Gy. In May 2021, CT scan showed that the process in the pancreas was stabilized, but in connection with the resumption of hypoglycemia and the emergence of dyshormonal osteopathy, a course of remote radiation therapy for the entire pancreas, SFD 1.8 Gy, TFD 20 Gy simultaneously with the introduction of bisphosphonates. Conclusions. Our patient demonstrates type I syndrome of multiple neo- plasms, neuroendocrine tumor of pancreas G1 T3N0M0 IIB stage. Due to multi-stage combined radiation therapy for 2 years it is possible to achieve stabilization of the process and reliable control of hypoglycemic attacks, which indicates the effectiveness of this method as an alternative to surgery in unresectable cases.

scholarly journals Epidemiology and antimicrobial susceptibility of invasive Escherichia coli infection in neonates from 2012 to 2019 in Xiamen, China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jidong Lai ◽  
Yao Zhu ◽  
Lixia Tang ◽  
Xinzhu Lin
Keyword(s):  
Escherichia Coli ◽  
Nosocomial Infection ◽  
Clinical Manifestation ◽  
Early Onset ◽  
Late Onset ◽  
Invasive Infection ◽  
E Coli ◽  
Escherichia Coli Infection ◽  
Sensitivity Rate ◽  
Main Clinical Manifestation

Abstract Background Escherichia coli (E. coli) is one of the important causative pathogens of neonatal invasive infection. The epidemiological and clinical profile of invasive E. coli infection in Chinese newborns is not well characterized. Methods Ninety-four infants with invasive E. coli infection were categorized into E. coli early onset disease (EOD) group (onset ≤72 h after birth) (n = 46) and E. coli late onset disease (LOD) group (onset > 72 h) (n = 48). We compared and analyzed the clinical characteristics and drug sensitivity profile of early-onset and late-onset E. coli invasive infection in neonates. Results The incidence of E. coli-EOD and E.coli-LOD was 0.45/1000 live births (LBs) and 0.47/1000 LBs, respectively. The incidence of gestational diabetes mellitus, perinatal fever, urinary tract infection, chorioamnionitis, and positive E. coli culture among mothers in the E. coli-EOD group were significantly higher than that in E. coli-LOD group. The incidence of premature birth, low-birth-weight, nosocomial infection, and hospitalization time were significantly higher in the E. coli-LOD group. The main disease in E. coli-EOD group was pneumonia (main clinical manifestation: dyspnea). The main disease in E. coli-LOD group was sepsis (main clinical manifestation: fever). The sensitivity rates of E. coli strains to ampicillin and piperacillin were low (25.00–28.79%); sensitivity to cephalosporins was also low except ceftazidime (lowest sensitivity rate: 57.14%). Sensitivity to compound preparations containing β-lactamase inhibitors was high, even for extended spectrum β-lactamase-positive strains (nearly 100%). Conclusion E. coli is an important cause of invasive infection of newborns in Xiamen, China. E. coli-EOD was largely attributable to perinatal factors, while E. coli-LOD was largely related to nosocomial infection. Compound preparations containing β-lactamase inhibitor or carbapenem antibiotics should be preferred for neonatal invasive infection by E. coli.

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