scholarly journals Comparison of autologous serum eye drops with conventional therapy in a randomised controlled crossover trial for ocular surface disease

2004 ◽  
Vol 88 (5) ◽  
pp. 647-652 ◽  
Author(s):  
B A Noble
Keyword(s):  
Ocular Surface ◽  
Conventional Therapy ◽  
Crossover Trial ◽  
Ocular Surface Disease ◽  
Autologous Serum ◽  
Eye Drops ◽  
Randomised Controlled ◽  
Serum Eye Drops

scholarly journals Evaluation of the Efficacy of 50% Autologous Serum Eye Drops in Different Ocular Surface Pathologies

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Francesco Semeraro ◽  
Eliana Forbice ◽  
Osvaldo Braga ◽  
Alessandro Bova ◽  
Attilio Di Salvatore ◽  
...  
Keyword(s):  
Ocular Surface ◽  
Conventional Therapy ◽  
Keratoconjunctivitis Sicca ◽  
Signs And Symptoms ◽  
Autologous Serum ◽  
Eye Drops ◽  
Blurred Vision ◽  
Group 2 ◽  
Serum Eye Drops ◽  
Group 1

Purpose. This study evaluated the efficacy of 50% autologous serum eye drops in ocular surface diseases not improved by conventional therapy.Methods. We analyzed two groups: (1) acute eye pathologies (e.g., chemical burns) and (2) chronic eye pathologies (e.g., recurrent corneal erosion, neurotropic keratitis, and keratoconjunctivitis sicca). The patients were treated for surface instability after conventional therapy. The patients received therapy 5 times a day until stabilization of the framework; they then reduced therapy to 3 times a day for at least 3 months. We analyzed the best corrected visual acuity, epithelial defects, inflammation, corneal opacity, and corneal neovascularization. We also analyzed symptoms such as tearing, burning, sense of foreign body or sand, photophobia, blurred vision, and difficulty opening the eyelids.Results. We enrolled 15 eyes in group 1 and 11 eyes in group 2. The average therapy period was 16 ± 5.86 weeks in group 1 and 30.54 ± 20.33 weeks in group 2. The epithelial defects all resolved. Signs and symptoms improved in both groups. In group 2, the defect recurred after the suspension of therapy in 2 (18%) patients; in group 1, no defects recurred.Conclusions. Autologous serum eye drops effectively stabilize and improve signs and symptoms in eyes previously treated with conventional therapy.

scholarly journals Effect of Autologous Serum Eye Drops in Patients with Sjögren Syndrome-related Dry Eye: Clinical and In Vivo Confocal Microscopy Evaluation of the Ocular Surface

In Vivo ◽  
2016 ◽  
Vol 30 (6) ◽  
pp. 931-938 ◽  
Author(s):  
FRANCESCO SEMERARO ◽  
ELIANA FORBICE ◽  
GIUSEPPE NASCIMBENI ◽  
MARCO TAGLIETTI ◽  
VITO ROMANO ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Dry Eye ◽  
Ocular Surface ◽  
Sjögren Syndrome ◽  
Autologous Serum ◽  
Sjogren Syndrome ◽  
Eye Drops ◽  
In Vivo Confocal Microscopy ◽  
Serum Eye Drops

scholarly journals Autologous serum eye drops for ocular surface disorders- a clinical study

2015 ◽  
Vol 3 (4) ◽  
pp. 394-399
Author(s):  
Dr. Vijaya Sahu ◽  
◽  
Dr. Nidhi Pandey ◽  
Dr. A K Chandrakar ◽  
Dr. M.L. Garg ◽  
...  
Keyword(s):  
Clinical Study ◽  
Ocular Surface ◽  
Autologous Serum ◽  
Eye Drops ◽  
Serum Eye Drops

scholarly journals A Case-Control Study on the Oxidative Balance of 50% Autologous Serum Eye Drops

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Patrícia Ioschpe Gus ◽  
Diane Marinho ◽  
Samira Zelanis ◽  
Adriane Belló-Klein ◽  
Claudete Locatelli ◽  
...  
Keyword(s):  
Ocular Surface ◽  
Case Control Study ◽  
Case Control ◽  
Demographic Characteristics ◽  
Ocular Surface Disease ◽  
Autologous Serum ◽  
Eye Drops ◽  
Healthy Controls ◽  
Oxidative Balance ◽  
Control Study

Importance.Autologous serum (AS) eye drops are recommended for severe dry eye in patients with ocular surface disease. No description of the antioxidant balance of AS eye drops has been reported in the literature.Objective.This study sought to evaluate the total reactive antioxidant potential (TRAP) and concentration of reactive oxygen species (ROS) in samples of 50% AS eye drops and their correlations with the demographic characteristics and lifestyle habits of patients with ocular surface disease and healthy controls.Design.This was a case-control study with a 3-month follow-up period.Participants. 16 patients with severe dry eye disease of different etiologies and 17 healthy controls matched by age, gender, and race were included.Results.TRAP and ROS were detected at all evaluated times. There were no differences in the mean ROS (p=0.429) or TRAP (p=0.475) levels between cases and controls. No statistically significant differences in the concentrations of ROS or TRAPs were found at 0, 15, or 30 days (pfor ROS = 0.087 andpfor TRAP = 0.93). Neither the demographic characteristics nor the lifestyle habits were correlated with the oxidative balance of the 50% AS eye drops.Conclusions and Relevance.Both fresh and frozen 50% AS eye drops present antioxidant capacities and ROS in an apparently stable balance. Moreover, patients with ocular surface disease and normal controls produce equivalent AS eye drops in terms of oxidative properties.

scholarly journals The Royal College of Ophthalmologists guidelines on serum eye drops for the treatment of severe ocular surface disease: executive summary

Eye ◽  
2017 ◽  
Vol 32 (1) ◽  
pp. 44-48 ◽  
Author(s):  
S Rauz ◽  
S-Y Koay ◽  
B Foot ◽  
S B Kaye ◽  
F Figueiredo ◽  
...  
Keyword(s):  
Royal College ◽  
Ocular Surface ◽  
Ocular Surface Disease ◽  
Eye Drops ◽  
Executive Summary ◽  
Serum Eye Drops

Efficacy of 2-Month Treatment With Cord Blood Serum Eye Drops in Ocular Surface Disease

Cornea ◽  
2017 ◽  
Vol 36 (8) ◽  
pp. 915-921 ◽  
Author(s):  
Giuseppe Giannaccare ◽  
Marina Buzzi ◽  
Michela Fresina ◽  
Claudio Velati ◽  
Piera Versura
Keyword(s):  
Blood Serum ◽  
Cord Blood ◽  
Ocular Surface ◽  
Ocular Surface Disease ◽  
Eye Drops ◽  
Cord Blood Serum ◽  
Serum Eye Drops
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