scholarly journals Dopamine is an indicator but not an independent risk factor for grade 3 retinopathy of prematurity in extreme low birthweight infants

2004 ◽  
Vol 88 (2) ◽  
pp. 309-a-310 ◽  
Author(s):  
K Allegaert
Keyword(s):  
Risk Factor ◽  
Retinopathy Of Prematurity ◽  
Independent Risk Factor ◽  
Low Birthweight ◽  
Grade 3

scholarly journals Cytokine Release Syndrome Is an Independent Risk Factor Associated With Platelet Transfusion Refractoriness After CAR-T Therapy for Relapsed/Refractory Acute Lymphoblastic Leukemia

2021 ◽  
Vol 12 ◽  
Author(s):  
Yadan Liu ◽  
Bin Liang ◽  
Yan Liu ◽  
Guoqing Wei ◽  
Wenjun Wu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Acute Lymphoblastic Leukemia ◽  
Platelet Transfusion ◽  
Independent Risk Factor ◽  
Lymphoblastic Leukemia ◽  
Cytokine Release ◽  
Cytokine Release Syndrome ◽  
Car T ◽  
Grade 3 ◽  
Platelet Transfusions

Background: Chimeric antigen receptor T cell (CAR-T) therapy is successful in improving treatment outcomes for relapsed/refractory acute lymphoblastic leukemia (R/R ALL). However, toxicities associated with CAR-T therapy are being increasingly identified. Pancytopenia is one of the most common complications after CAR-T therapy, and platelet transfusions are an essential part of its supportive care.Study Design and Methods: This study aimed to assess the effectiveness of platelet transfusions for R/R ALL patients at our single center and identify associated risk factors. Overall, 44 R/R ALL patients were enrolled in this study, of whom 26 received CAR-T therapy and 18 received salvage chemotherapy.Result: Patients in the CAR-T group had a higher incidence of platelet transfusion refractoriness (PTR) (15/26, 57.7%) than those in the chemotherapy group (3/18, 16.7%) (p = 0.007). For patients receiving CAR-T therapy, multivariate analysis showed that the grade of cytokine release syndrome (CRS) was the only independent risk factor associated with PTR (p = 0.007). Moreover, higher peak serum IL-6 and IFN-γ levels suggested a higher risk of PTR (p = 0.024 and 0.009, respectively). Patients with PTR received more platelet infusion doses than those without PTR (p = 0.0426). Patients with PTR had more grade 3–4 bleeding events than those without PTR (21.4 vs. 0%, p = 0.230), and the cumulative incidence of grade 3–4 bleeding event was different (p = 0.023).Conclusion: We found for the first time that PTR is associated with the CRS grade. Improved knowledge on the mechanisms of PTR after CAR-T therapy is needed to design a rational therapeutic strategy that aims to improve the efficiency of transfusions.

scholarly journals Persistent Tunica Vasculosa Lentis as an Independent Risk Factor for Treatment in Retinopathy of Prematurity

2020 ◽  
Author(s):  
Nimesh A. Patel ◽  
Kenneth C. Fan ◽  
Hasenin Al-Khersan ◽  
Nicolas A. Yannuzzi ◽  
Dhariana Acon ◽  
...  
Keyword(s):  
Risk Factor ◽  
Retinopathy Of Prematurity ◽  
Independent Risk Factor ◽  
Tunica Vasculosa Lentis

scholarly journals Maternal diabetes mellitus as an independent risk factor for clinically significant retinopathy of prematurity severity in neonates less than 1500g

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0236639 ◽  
Author(s):  
Chibuzor Nonye Opara ◽  
Mopelola Akintorin ◽  
Allison Byrd ◽  
Natascha Cirignani ◽  
Similolu Akintorin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Retinopathy Of Prematurity ◽  
Independent Risk Factor ◽  
Maternal Diabetes ◽  
Clinically Significant ◽  
Maternal Diabetes Mellitus

scholarly journals Can 5-minute Apgar score be considered as an additional independent risk factor for screening of retinopathy of prematurity?

2020 ◽  
Vol 8 (1) ◽  
pp. 4-4
Author(s):  
Amir Eftekhari Milani ◽  
Mohamad Reza Niyousha ◽  
Ali Kiavar ◽  
Hanieh Sakha ◽  
Ali Mahdavi Fard ◽  
...  
Keyword(s):  
Risk Factor ◽  
Birth Weight ◽  
Gestational Age ◽  
Retinopathy Of Prematurity ◽  
Apgar Score ◽  
Neonatal Intensive Care ◽  
Independent Risk Factor ◽  
P Value ◽  
Cross Sectional ◽  
Minute Apgar Score

Introduction: Because of increasing the population of premature infants due to improving neonatal care we try to find other independent criteria in addition to birth weight and gestational age to reduce the number of infants who need a retinopathy of prematurity (ROP) screening examination. Methods: This is a retrospective cross-sectional study, included 150 preterm infants with gestational age of ≤ 32 weeks or birth weight ≤ 1500 g or receives oxygen therapy for more than 2 days, who were examined from the fourth week of life for ROP in Tabriz Al-Zahra hospital’s neonatal intensive care unit (NICU), from March 2017 to January 2018. All infants with other risk factors such as multi gestational pregnancy, blood transfusion or exchange, phototherapy, underlying disease, cerebral hemorrhage, chronic lung disease and sepsis were excluded from the study. Infants divided to two group ROP (n=47) and non-ROP (n=133) and their 5-minute Apgar score was Apgar score was compared as an independent risk factor. Exploratory data analysis was performed using descriptive measures with independent samples t tests. Kolmogorov-Smirnov tests were used to test the normality of data distribution. Results: The mean 5-minute Apgar scores were statistically lower in ROP group (5.4±2.3) than non-ROP group 6.2±2.1 (P value=0.041). Conclusion: Apgar score was statistically significant, but in light of the very close results obtained, it seems prudent to consider an independent risk factor.

scholarly journals Duration of anaemia during the first week of life is an independent risk factor for retinopathy of prematurity

2018 ◽  
Vol 107 (5) ◽  
pp. 759-766 ◽  
Author(s):  
Pia Lundgren ◽  
Sam E. Athikarisamy ◽  
Sanjay Patole ◽  
Geoffrey C. Lam ◽  
Lois E. Smith ◽  
...  
Keyword(s):  
Risk Factor ◽  
Retinopathy Of Prematurity ◽  
Independent Risk Factor

Myocarditis in patients treated with anti–programmed death-1/programmed death ligand 1 therapy.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e14579-e14579
Author(s):  
Hanping Wang ◽  
Xiaoxiao Guo ◽  
Ran Tian ◽  
Xiaoyan Si ◽  
Xiaotong Zhang ◽  
...  
Keyword(s):  
Risk Factor ◽  
Mortality Rate ◽  
Prognostic Model ◽  
Independent Risk Factor ◽  
Clinical Symptoms ◽  
Checkpoint Inhibitor ◽  
Total Duration ◽  
Cardiac Insufficiency ◽  
Programmed Death ◽  
Grade 3

e14579 Background: We retrospectively analysed the cases of immune checkpoint inhibitor(ICI) -associated myocarditis managed in PUMCH. We aim to investigate the clinical characteristics of myocarditis and the risk factors affecting the prognosis. Methods: Medical records of all checkpoint inhibitor-related myocarditis were reviewed retrospectively. Descriptive statistics were used for the report of clinical outcomes. Univariate and multivariate Logistic analyses were performed to establish a prognostic model. Results: The median age of 19 patients was 64 years old (range 39̃80 years). The median time of onset from the iniatial of ICIs was 21 days (ranging from 2 to 375 days). Seven cases were grade 4 (36.8%), 2 cases were grade 3 (10.5%), 8 cases were grade 2 (42.1%), and 2 cases were grade 1 (10.5%). Clinical symptoms included dyspnea (13/19, 68.4%), fatigue (11/19, 57.9%), myalgia/myasthenia (9/19, 47.4%), sweating (6/19, 31.6%) and palpitation (6/19, 31.6%) et al. 47.4% (9/19) of the patients showed cardiac insufficiency/hemodynamic instability at first, and 52.6% (10/19) of the patients showed symptoms related to myositis first. cTnI and CK increased in all patients. The level of cTnI was significantly higher in grade 3̃4 than that in grade 1-2. NTproBNP was elevated in all grade 4 cases and one grade 3 case. The LVEF decreased only in 4 patients with grade 4 myocarditis (4/19, 22.2%). The electrocardiogram showed ventricular arrhythmia in 4 cases and complete atrioventricular block (3°AVB) in 3 cases. All patients were treated with corticosteroids (GCS). Grade 4 (6 cases), grade 3 (1 case) and grade 2 (2 cases) were given GCS pulse dose. The median total duration of GCS treatment was 42 days (range: 14-60 days). Three patients were treated with tocilizumab and one patient with infliximab. All patients with grade 3-4 and 2 patients with grade 2 were also treated with IVIG. Pacemakers were implanted in 3 patients with 3°AVB. The mortality rate of 19 cases was 21.1% (4/19), and the mortality rate of grade 4 myocarditis was 42.9%(3/7). The longer course before GCS therapy (p = 0.023), the higher NTproBNP (p = 0.030) and the lower LVEF value (p = 0.014) were found in the death group compared to the survival group. Logistic regression analysis showed that LVEF is an independent risk factor. The myocarditis prognostic model was condstructed as follows: Y = 8.794-18.002*LVEF, the prognostic critical value of LVEF was 57.5%, the area under the ROC curve of the prognostic model was 0.894 (95%CI: 0.735̃1.000), the sensitivity was 0.769, and the specificity was 1.000. Conclusions: We describe the largest single-center immune myocarditis cohort to date. Paying attention to the symptoms related to myositis is helpful to find more grade 1-2 myocarditis. cTnI is sensitive to myocarditis, and NTproBNP is of great significance to grade 3 ̃ 4 cases. LVEF < 57% may be an independent risk factor for poor prognosis.

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