Surgery for primary basal cell carcinoma including the eyelid margins with intraoperative frozen section control: comparative interventional study with a minimum clinical follow up of 5 years

Abstract Context.—Metastatic basal cell carcinoma (BCC) is relatively rare and is seldom considered a complication in the routine treatment and follow-up of patients with BCC. Although multiple studies have tried to distinguish aggressive from nonaggressive BCCs, to our knowledge, no consistent clinical, histopathologic, or immunohistochemical features have yet been reported. Objective.—To report 4 cases of metastatic BCCs and to evaluate these in addition to known nonmetastatic BCCs with specific immunostains in an attempt to find distinct morphologic or immunohistochemical patterns that could be helpful in identifying aggressive BCCs. Design.—We reviewed 4 cases of metastatic BCCs and recorded the clinical and morphologic findings. We then searched our archives for 14 cases of BCC that followed the usual nonaggressive course. We evaluated these 18 cases with immunohistochemical stains for Ki-67, p53, and bcl-2. Results.—In metastasizing BCC, Ki-67 staining was slightly higher in metastatic sites than in primary sites (average 63% and 51%, respectively). p53 was expressed in 3 of 4 primary sites and 2 of 4 metastatic sites. Bcl-2 was positive in both primary and metastatic sites in 3 of 4 cases. In the 14 cases of nonaggressive BCC, staining for Ki-67 averaged 38%, p53 was positive in 11 cases, and Bcl-2 staining was noted in 13 cases. Conclusions.—Overall, in the small sample that we evaluated, the immunohistochemical markers for Ki-67, p53, and Bcl-2 did not distinguish between metastatic and nonaggressive BCCs.

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Cryosurgical management of basal cell carcinoma: in vivo follow-up using reflectance confocal microscopy

International Journal of Dermatology ◽

10.1111/ijd.14301 ◽

2018 ◽

Vol 58 (2) ◽

pp. e30-e32 ◽

Cited By ~ 2

Author(s):

Paola Pasquali ◽

Gonzalo Segurado-Miravalles ◽

Azael Freites-Martínez ◽

Salvador González-Rodriguez

Keyword(s):

Confocal Microscopy ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Reflectance Confocal Microscopy

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Multiple, Multiloculated, and Recurrent Keratocysts of the Mandible and Maxilla in Association with Gorlin-Goltz (Nevoid Basal-Cell Carcinoma) Syndrome: A Pediatric Case Report and Follow-up over 5 Years

Case Reports in Dentistry ◽

10.1155/2018/7594840 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8

Author(s):

P. Santander ◽

E. M. C. Schwaibold ◽

F. Bremmer ◽

S. Batschkus ◽

P. Kauffmann

Keyword(s):

Case Report ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Radiographic Finding ◽

Permanent Teeth ◽

High Recurrence Rate ◽

Surgical Removal ◽

Dental Maturation

Background. We report a case of multiple keratocysts first diagnosed in an 8-year-old boy. Case report. The incidental radiographic finding of a cystic lesion in an 8-year-old boy led to the surgical enucleation and further diagnosis of a keratocyst associated with a tooth crown. In the course of dental maturation from deciduous to permanent teeth, the boy presented new lesions, always associated with the crowns of teeth. Gorlin-Goltz (nevoid basal-cell carcinoma) syndrome was suspected, and the genetic analysis detected a previously undescribed germline variant in the PTCH1 gene. Treatment. This included a surgical removal of the cystic lesions, as well as the affected teeth. Follow-up. Due to the high recurrence rate of the keratocysts, frequent radiological checks were performed over a 5-year period.

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