scholarly journals Failure of fresh frozen plasma infusion and vitamin K to correct elevated international normalised ratio

2012 ◽  
Vol 2012 (jul12 2) ◽  
pp. bcr0820114635-bcr0820114635
Author(s):  
P. Vitish-Sharma ◽  
R. Shah ◽  
M. Anjari ◽  
J. Knowles ◽  
K. Qurashi
Keyword(s):  
Vitamin K ◽  
Fresh Frozen Plasma ◽  
Plasma Infusion ◽  
International Normalised Ratio ◽  
Fresh Frozen ◽  
Frozen Plasma

Factors associated with failure to correct the international normalised ratio following fresh frozen plasma administration among patients treated for warfarin-related major bleeding

2012 ◽  
Vol 107 (04) ◽  
pp. 662-672 ◽  
Author(s):  
Leigh White ◽  
Mark Friedman ◽  
Christine Nichols ◽  
Jordan Menzin ◽  
Jan Hoesche ◽  
...  
Keyword(s):  
Major Bleeding ◽  
Fresh Frozen Plasma ◽  
Charlson Score ◽  
Factors Associated ◽  
International Normalised Ratio ◽  
Fresh Frozen ◽  
Retrospective Database Analysis ◽  
Definition Of ◽  
Frozen Plasma ◽  
Retrospective Database

SummaryThis study assessed the frequency and factors associated with failure to correct international normalised ratio (INR) in patients administered fresh frozen plasma (FFP) for warfarin-related major bleeding. This retrospective database analysis used electronic health records from an integrated health system. Patients who received FFP between 01/01/2004 and 01/31/2010, and who met the following criteria were selected: major haemorrhage diagnosis the day before to the day after initial FFP administration; INR ≥2 on the day before or the day of FFP and another INR result available; warfarin prescription within 90 days. INR correction (defined as INR ≤1.3) was evaluated at the last available test up to one day following FFP. A total of 414 patients met selection criteria (mean age 75 years, 53% male, mean Charlson score 2.5). Patients presented with gastrointestinal bleeding (58%), intracranial haemorrhage (38%) and other bleed types (4%). The INR of 67% of patients remained uncorrected at the last available test up to one day following receipt of FFP. In logistic regression analysis, the INR of patients who were older, those with a Charlson score of 4 or greater, and those with non-ICH bleeds (odds ratio vs. intracranial bleeding 0.48; 95% confidence interval 0.31–0.76) were more likely to remain uncorrected within one day following FFP administration. In an alternative definition of correction, (INR ≤1.5), 39% of patients’ INRs remained uncorrected. For a substantial proportion of patients, the INRs remain inadequately or uncorrected following FFP administration, with estimates varying depending on the INR threshold used.

Prothrombin Complex Concentrates are Superior to Fresh Frozen Plasma for Emergency Reversal of Vitamin K Antagonists: A Meta-Analysis in 2606 Subjects

Drugs ◽  
2019 ◽  
Vol 79 (14) ◽  
pp. 1557-1565 ◽  
Author(s):  
Robert Hill ◽  
Thang S. Han ◽  
Irina Lubomirova ◽  
Nikhil Math ◽  
Paul Bentley ◽  
...  
Keyword(s):  
Vitamin K ◽  
Meta Analysis ◽  
Vitamin K Antagonists ◽  
Fresh Frozen Plasma ◽  
Prothrombin Complex Concentrates ◽  
Fresh Frozen ◽  
Frozen Plasma

scholarly journals Viscoelastometry guided fresh frozen plasma infusion for postpartum haemorrhage: OBS2, an observational study

2017 ◽  
Vol 119 (3) ◽  
pp. 422-434 ◽  
Author(s):  
P.W. Collins ◽  
R. Cannings-John ◽  
D. Bruynseels ◽  
S. Mallaiah ◽  
J. Dick ◽  
...  
Keyword(s):  
Observational Study ◽  
Postpartum Haemorrhage ◽  
Fresh Frozen Plasma ◽  
Plasma Infusion ◽  
Fresh Frozen ◽  
Frozen Plasma

Clinical Application of Prothrombin Complex Concentrate in Blood Management in Patients

2017 ◽  
Vol 37 (2) ◽  
pp. 49-56
Author(s):  
Sherri Ozawa ◽  
Tiffany Nelson
Keyword(s):  
Vitamin K ◽  
Prothrombin Complex Concentrate ◽  
International Normalized Ratio ◽  
Fresh Frozen Plasma ◽  
Drug Discontinuation ◽  
Clotting Factors ◽  
Urgent Surgery ◽  
Anticoagulant Reversal ◽  
Fresh Frozen ◽  
Frozen Plasma

Management of patients receiving anticoagulants is a major factor in achieving better outcomes. Anticoagulant therapy may need to be discontinued or rapidly reversed before urgent surgery or invasive procedures. In these situations, treatment with concentrated vitamin K, fresh frozen plasma, and/or clotting factors can achieve more rapid anticoagulant reversal than can drug discontinuation alone. Activated prothrombin complex concentrate is used to treat hemophiliac patients with acquired factor VIII inhibitors. Nonactivated prothrombin complex concentrates are used for anticoagulant reversal. The concentrates are effective within minutes of dosing, providing a nearly immediate decrease in the international normalized ratio. The concentrates are lyophilized powders that can be quickly reconstituted, do not require ABO blood typing before use, and contain 25 times the concentration of vitamin K–dependent clotting factors compared with fresh frozen plasma. Studies suggest that the concentrates are associated with better clinical end points than is fresh frozen plasma.

scholarly journals The use of fresh frozen plasma infusion in a patient with congenital factor V deficiency in a case of eye ball extraction

1976 ◽  
Vol 7 (5) ◽  
pp. 400-405
Author(s):  
Hiroshi INABA ◽  
Yasumasa SUGA ◽  
Osamu TATSUZAWA ◽  
Masatoshi KOSAKI ◽  
Toshio SEKIMOTO ◽  
...  
Keyword(s):  
Fresh Frozen Plasma ◽  
Factor V ◽  
Plasma Infusion ◽  
Factor V Deficiency ◽  
Fresh Frozen ◽  
Frozen Plasma ◽  
Congenital Factor

Role of fresh frozen plasma infusion in correction of coagulopathy of chronic liver disease: a dual phase study

2003 ◽  
Vol 98 (6) ◽  
pp. 1391-1394 ◽  
Author(s):  
Wael I. Youssef ◽  
Fernando Salazar ◽  
Srinivasan Dasarathy ◽  
Timothy Beddow ◽  
Kevin Daniel Mullen
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Fresh Frozen Plasma ◽  
Chronic Liver ◽  
Dual Phase ◽  
Plasma Infusion ◽  
Phase Study ◽  
Fresh Frozen ◽  
Frozen Plasma

INEFFICACY OF FRESH FROZEN PLASMA THERAPY OF MUCOPOLYSACCHARIDOSIS II

PEDIATRICS ◽  
1972 ◽  
Vol 50 (5) ◽  
pp. 693-701
Author(s):  
Robert P. Erickson ◽  
Robert Sandman ◽  
William van B. Robertson ◽  
Charles J. Epstein
Keyword(s):  
Fresh Frozen Plasma ◽  
Activity Levels ◽  
Acid Hydrolases ◽  
Short Term Treatment ◽  
Plasma Therapy ◽  
Noticeable Effect ◽  
Mucopolysaccharidosis Ii ◽  
Plasma Infusion ◽  
Fresh Frozen ◽  
Frozen Plasma

Patients with Mucopolysaccharidosis II (Hunter's syndrome) were given short-term treatment with large infusions of fresh frozen plasma to evaluate recent claims of clinical and chemical improvement by such therapy. Clinical behavior, urine glycosaminoglycans, and skin, serum, and urine acid hydrolases were evaluated by single-blind techniques. There was no noticeable effect of fresh frozen plasma infusion on the performance of these patients. The total urinary excretion of glycosaminoglycans was not altered by the infusions and there was no change in the size of the glycosaminoglycan fragments. The abnormal skin activity levels of β-galactosidase, β-glucuronidase, and N-acetylglucosaminidase were unaltered three days after fresh frozen plasma infusion and, similarly, the abnormal levels of these enzymes in the serum persisted without significant change during the ten days of evaluation.

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