scholarly journals Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis

1998 ◽  
Vol 57 (7) ◽  
pp. 408-413 ◽  
Author(s):  
P L E M Van Lent ◽  
A E M Holthuysen ◽  
N Van Rooijen ◽  
L B A V. De Putte ◽  
W B V. Den Berg
Keyword(s):  
Collagen Type ◽  
Cartilage Destruction ◽  
Type Ii ◽  
Collagen Type Ii ◽  
Synovial Lining ◽  
Synovial Lining Cells ◽  
Clodronate Liposomes

scholarly journals Prospective Clinical Trial for Septic Arthritis: Cartilage Degradation and Inflammation Are Associated with Upregulation of Cartilage Metabolites

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Hagen Schmal ◽  
Anke Bernstein ◽  
Matthias J. Feucht ◽  
Benjamin Erdle ◽  
Jan M. Pestka ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Disease Severity ◽  
Collagen Type ◽  
Cartilage Degradation ◽  
Cartilage Destruction ◽  
Prospective Clinical Trial ◽  
Type Ii ◽  
Collagen Type Ii ◽  
Biomarker Analysis ◽  
Cartilage Turnover

Background. Intra-articular infections can rapidly lead to osteoarthritic degradation. The aim of this clinical biomarker analysis was to investigate the influence of inflammation on cartilage destruction and metabolism.Methods. Patients with acute joint infections were enrolled in a prospective clinical trial and the cytokine composition of effusions (n=76) was analyzed. Characteristics of epidemiology and disease severity were correlated with levels of cytokines with known roles in cartilage turnover and degradation.Results. Higher synovial IL-1βconcentrations were associated with clinical parameters indicating a higher disease severity (p<0.03) excluding the incidence of sepsis. Additionally, intra-articular IL-1βlevels correlated with inflammatory serum parameters as leucocyte counts (LC) and C-reactive protein concentrations (p<0.05) but not with age or comorbidity. Both higher LC and synovial IL-1βlevels were associated with increased intra-articular collagen type II cleavage products (C2C) indicating cartilage degradation. Joints with preinfectious lesions had higher C2C levels. Intra-articular inflammation led to increased concentrations of typical cartilage metabolites as bFGF, BMP-2, and BMP-7. Infections withStaphylococcusspecies induced higher IL-1βexpression but less cartilage destruction than other bacteria.Conclusion. Articular infections have bacteria-specific implications on cartilage metabolism. Collagen type II cleavage products reliably mark destruction, which is associated with upregulation of typical cartilage turnover cytokines. This trial is registered withDRKS00003536, MISSinG.

Specificity and T cell receptor β chain usage of a human collagen type II-reactive T cell clone derived from a healthy individual

1992 ◽  
Vol 22 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Tan Yan ◽  
Harald Burkhardt ◽  
Thomas Ritter ◽  
Barbara Bröker ◽  
Karl Heinz Mann ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Collagen Type ◽  
Cell Clone ◽  
Cell Receptor ◽  
Type Ii ◽  
Collagen Type Ii ◽  
T Cell Clone ◽  
Human Collagen ◽  
Β Chain

Localization of pro-collagen type ii mrna and collagen type ii in the healing tooth socket of the rat

1995 ◽  
Vol 40 (3) ◽  
pp. 181-185 ◽  
Author(s):  
H. Devlin ◽  
J. Hoyland ◽  
A.J. Freemont ◽  
P. Sloan
Keyword(s):  
Collagen Type ◽  
Type Ii ◽  
Collagen Type Ii ◽  
Tooth Socket

scholarly journals Role of undenatured collagen type ii in management of osteoarthritis: A hospital based study

2020 ◽  
Vol 6 (4) ◽  
pp. 747-750
Author(s):  
Dr. Sathik Babu ◽  
Dr. Pradeep Elangovan ◽  
Dr. Dinesh Kumar S
Keyword(s):  
Collagen Type ◽  
Type Ii ◽  
Collagen Type Ii
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