scholarly journals Von Willebrand factor, thrombomodulin, thromboxane, beta-thromboglobulin and markers of fibrinolysis in primary Raynaud's phenomenon and systemic sclerosis.

1996 ◽  
Vol 55 (2) ◽  
pp. 122-127 ◽  
Author(s):  
A L Herrick ◽  
K Illingworth ◽  
A Blann ◽  
C R Hay ◽  
S Hollis ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Von Willebrand Factor ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Primary Raynaud’S Phenomenon ◽  
Von Willebrand ◽  
Willebrand Factor

von Willebrand factor activity in primary and in scleroderma-associated Raynaud's phenomenon

The Lancet ◽  
1990 ◽  
Vol 335 (8697) ◽  
pp. 1095 ◽  
Author(s):  
R. Cuenca ◽  
J. Fernandez-Cortijo ◽  
V. Fonollosa ◽  
J. Lima ◽  
C.P. Simeon ◽  
...  
Keyword(s):  
Von Willebrand Factor ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Factor Activity ◽  
Von Willebrand ◽  
Willebrand Factor

The associations between plasma levels of von Willebrand factor and fibrinogen with Raynaud’s phenomenon in men and women

2000 ◽  
Vol 108 (7) ◽  
pp. 583-586 ◽  
Author(s):  
Liana Fraenkel ◽  
Geoffrey H Tofler ◽  
Yuqing Zhang ◽  
Halit Silbershatz ◽  
Ralph B D’Agostino ◽  
...  
Keyword(s):  
Von Willebrand Factor ◽  
Plasma Levels ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Men And Women ◽  
Von Willebrand ◽  
Willebrand Factor

scholarly journals Supranormal von Willebrand factor multimers in scleroderma

Blood ◽  
1989 ◽  
Vol 73 (6) ◽  
pp. 1586-1591 ◽  
Author(s):  
PM Mannucci ◽  
R Lombardi ◽  
A Lattuada ◽  
E Perticucci ◽  
R Valsecchi ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Platelet Aggregation ◽  
Von Willebrand Factor ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Severity Of The Disease ◽  
Partially Occluded ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Normal Controls

Abstract Platelet adhesion-aggregation reactions play an early and pivotal role in the pathogenesis of systemic sclerosis in scleroderma, but the mechanisms are incompletely understood. We determined whether or not plasma from 11 consecutive patients with scleroderma contained a subset of larger than normal (“supranormal”) multimers of von Willebrand factor (vWF) that are potent inducers of platelet aggregation and adhesion. Supranormal multimers were found in all patients on at least one of two different occasions 9 to 12 months apart, whatever the duration and severity of the disease, but in none of the normal controls. Administration of low-dose aspirin (40 mg) to five of the 11 patients for ten days to inhibit the platelet release reaction slightly reduced the amounts of supranormal multimers suggesting that they might originate in part from platelets. Supranormal multimers may contribute to the pathogenesis of systemic sclerosis by inducing platelet aggregation and enhancing adhesion to subendothelium under the conditions of elevated shear stress occurring in the partially occluded vessels of the arterial microcirculation of scleroderma.

scholarly journals INCREASED NAILFOLD CAPILLARY DIMENSIONS IN PRIMARY RAYNAUD'S PHENOMENON AND SYSTEMIC SCLEROSIS

Rheumatology ◽  
1995 ◽  
Vol 35 (11) ◽  
pp. 1127-1131 ◽  
Author(s):  
M. BUKHARI ◽  
A. L. HERRICK ◽  
T. MOORE ◽  
J. MANNING ◽  
M. I. V. JAYSON
Keyword(s):  
Systemic Sclerosis ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Primary Raynaud’S Phenomenon

Characterization of Endothelin-Binding Sites in Human Skin and their Regulation in Primary Raynaud's Phenomenon and Systemic Sclerosis

1993 ◽  
Vol 101 (1) ◽  
pp. 73-78 ◽  
Author(s):  
Gregory A Knock ◽  
Giorgio Terenghi ◽  
Christopher B Bunker ◽  
Helen A. Bull ◽  
Pauline M. Dowd ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Human Skin ◽  
Binding Sites ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Primary Raynaud’S Phenomenon
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