scholarly journals Clearnace of Fe59-labelled erythrocytes from normal and inflamed rabbit knee joints. I. Relationship to the anaemia of rheumatoid arthritis.

1969 ◽  
Vol 28 (5) ◽  
pp. 548-551 ◽  
Author(s):  
K D Muirden
Keyword(s):  
Rheumatoid Arthritis ◽  
Knee Joints ◽  
Rabbit Knee

scholarly journals Dose-dependent effect of betamethasone on the articular cartilage (experimental study)

2021 ◽  
Vol 27 (1) ◽  
pp. 80-86
Author(s):  
A.N. Nuriakhmetov ◽  
◽  
I.F. Akhtiamov ◽  
D.E. Tsyplakov ◽  
A.M. Abdullah ◽  
...  
Keyword(s):  
Subchondral Bone ◽  
Inflammatory Cell ◽  
Left Knee ◽  
Knee Joints ◽  
Control Group ◽  
Rabbit Knee ◽  
Frequency Of Use ◽  
The Right ◽  
Dose Dependent ◽  
Dose Dependent Effect

Introduction Glucocorticosteroid injections have been widely used in clinical practice. Betamethasone is one of the agents of this group of drugs. Its efficacy and therapeutic effect with intra-articular administration are undeniable. There are special instructions on the dosage and frequency of use of the drug but unfortunately there are cases of its wrong administration. There is also an evidence of an adverse effect on cartilage both of the drug itself and its combination with local anesthetics. Aim Evaluation of the results of different weekly intra-articular protocols of betamethasone administration on histological preparations of rabbit knee joints. Methods Histological preparations of the right knee joints of three groups of rabbits were studied: after one, three, and six administrations of betamethason per week and the control intact left knee joints. Results Histological preparations of the control group and the group with a single weekly administration of the drug did not have any changes in the structure of diarthrosis. Dystrophic and necrotic changes affecting all morphological components were observed in the joints of animals that received intra-articular injections of betamethason three times a week (compared to a single injection, the area of dystrophy and necrosis of the cartilage was greater by 10.05 ± 0.75 % (p < 0.05), of subchondral bone by 8.11 ± 0.5 % (p < 0.001), and of synovium by 6.25 ± 0.32 % (p < 0.05). The group with six injections of the drug per week had the most pronounced changes. The area of necrotic changes of the cartilage was greater by 6.39 ± 0.75 % than in the group with three injections per week (p < 0.001), of subchondral bone by 11.18 ± 0.5 % (p < 0.001), of synovium by 6.12 ± 0.32 % (p < 0.001). Discussion Inflammatory cell infiltration of joint structures was absent in all cases. It indicates an aseptic nature of tissue necrosis. Evidence has been obtained between the increase in the frequency of intra-articular injections of betamethasone and the severity of dystrophic and necrotic changes in all morphological components of the joint.

Evaluation of the Impact of the Whole-body Cryotherapy Treatment on the Functional Condition of the Knee Joints in Patients with Rheumatoid Arthritis

2021 ◽  
Vol 63 (2) ◽  
pp. 93-98
Author(s):  
Agnieszka Przedborska ◽  
Mateusz Szymczak ◽  
Małgorzata Kilon ◽  
Łukasz Kikowski ◽  
Jan Raczkowski
Keyword(s):  
Rheumatoid Arthritis ◽  
Muscle Strength ◽  
Range Of Motion ◽  
Functional State ◽  
Functional Condition ◽  
Knee Joints ◽  
Whole Body ◽  
Gait Function ◽  
Whole Body Cryotherapy ◽  
The Impact

Introduction: Rheumatoid arthritis (RA) is a chronic disease that leads to disability of patients. The use of the whole-body cryotherapy treatment for RA patients provides analgesic and anti-inflammatory effects and improves their efficiency. Aim: Assessment of the effect of the whole-body cryotherapy treatment on the functional state of knee joints for patients with RA. Material and Method: The study was conducted on a group of 30 RA patients, who underwent a series of 10 whole-body cryotherapy treatment. The effectiveness and efficiency of the applied therapy was assessed on the basis of: the VAS scale, the Laitinen scale, the assessment of the range of motion, muscle strength with the MicroFet dynamometer and the Up and Go test. Results: As a result of the applied whole-body cryotherapy treatment, a reduction in the intensity of pain, measured with the VAS scale and the Laitinen scale, and a reduction in the duration of morning stiffness by about 55% were found. There was an increase in the range of motion and muscle strength. The time needed to perform the Up and Go test was reduced by 17%. Conclusions: The whole-body cryotherapy treatment is an effective analgesic method of physiotherapy for patients with RA. It provides an improvement in the functional state, increases the range of motion, muscle strength and improves the gait function.

Isotope Studies in Normal and Diseased Knee Joints: 99mTc Uptake Related to Clinical Assessment and to Synovial Perfusion Measured by the 133Xe Clearance Technique

1971 ◽  
Vol 40 (4) ◽  
pp. 327-336 ◽  
Author(s):  
W. C. Dick ◽  
S. D. Deodhar ◽  
Carol J. Provan ◽  
G. Nuki ◽  
W. W. Buchanan
Keyword(s):  
Rheumatoid Arthritis ◽  
Normal Subjects ◽  
Knee Joints ◽  
133Xe Clearance ◽  
Normal Limits ◽  
Human Volunteers ◽  
Normal Human ◽  
Clinical Indices ◽  
Isotope Studies ◽  
The Mean

1. Uptake of intravenously administered radioactive technetium (99mTc) was measured over the knee joints in normal human volunteers, in patients with osteoarthritis and in groups of synovectomized and unoperated patients with rheumatoid arthritis. The uptake was compared with clinical indices of inflammation (pain, tenderness swelling and stiffness), and the clearance rate of intra-articularly injected radioactive xenon (133Xe). The 99mTc uptakes were found to be unrelated to the isotope dose and the day-to-day reproducibility was acceptable. 2. The mean uptake of 99mTc was within normal limits in osteoarthritis. Both in synovectomized and in unoperated rheumatoid arthritis 99mTc uptake was significantly higher than in normal subjects. 3. Of the clinical indices studied significant correlation of 99mTc uptake was found with pain and swelling in all groups of patients studied. 4. Faster clearance of 133Xe in unoperated rheumatoid arthritis correlated well with the higher 99mTc uptakes. 5. The results confirm that 99mTc uptakes are raised in inflammatory arthritis but not in degenerative arthritis. The relation of 99mTc uptake to the clinical indices of inflammation and to the 133Xe clearance from the joint is discussed.

Protein kinase C activator inhibits progression of osteoarthritis induced in rabbit knee joints

1996 ◽  
Vol 127 (6) ◽  
pp. 540-544 ◽  
Author(s):  
Chiaki Hamanishi ◽  
Makoto Hashima ◽  
Hiroshi Satsuma ◽  
Seisuke Tanaka
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Knee Joints ◽  
Rabbit Knee ◽  
Kinase C

Intra-articular Histopathologic Changes Secondary to Local Lead Intoxication in Rabbit Knee Joints

1995 ◽  
Vol 38 (4) ◽  
pp. 668-671 ◽  
Author(s):  
Alberto A. Bolanos ◽  
Vincent J. Vigorita ◽  
Robert I. Meyerson ◽  
Francis G. D'Ambrosio ◽  
Eli Bryk
Keyword(s):  
Knee Joints ◽  
Lead Intoxication ◽  
Rabbit Knee ◽  
Histopathologic Changes

scholarly journals Elimination of Tritium-Labelled Hyaluronic Acid from Normal and Osteoarthritic Rabbit Knee Joints

1997 ◽  
Vol 35 (5) ◽  
Author(s):  
Klaus Lindenhayn ◽  
Hans-Hubert Heilmann ◽  
Thorsten Niederhausen ◽  
Hans-Ullrich Walther ◽  
Kristina Pohlenz
Keyword(s):  
Hyaluronic Acid ◽  
Knee Joints ◽  
Rabbit Knee
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