scholarly journals Haematological changes in adjuvant disease in the rat. II. Iron metabolism and 51Cr erythrocyte survival.

1969 ◽  
Vol 28 (2) ◽  
pp. 172-179 ◽  
Author(s):  
M Mikolajew ◽  
Z Kuratowska ◽  
M Kossakowska ◽  
M Plachecka ◽  
M Kopec
Keyword(s):  
Iron Metabolism ◽  
Erythrocyte Survival ◽  
Adjuvant Disease ◽  
Haematological Changes

scholarly journals Radioactive Iron Metabolism and Erythrocyte Survival Studies of the Mechanism of the Anemia Associated with Rheumatoid Arthritis1

1957 ◽  
Vol 36 (7) ◽  
pp. 1043-1058 ◽  
Author(s):  
Emil J. Freireich ◽  
Joseph F. Ross ◽  
Theodore B. Bayles ◽  
Charles P. Emerson ◽  
Stuart C. Finch
Keyword(s):  
Iron Metabolism ◽  
Erythrocyte Survival ◽  
Survival Studies

Anti-leukemia activity of cranberry A-PACS is mediated by disruption of iron metabolism

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
L Bystrom ◽  
HT Hsu ◽  
K Patel ◽  
E Yiantsidis ◽  
C Neto ◽  
...  
Keyword(s):  
Iron Metabolism

Radiation Sickness after Therapeutic Administration of 806 mCi of 131I for Thyroid Cancer

1967 ◽  
Vol 06 (02) ◽  
pp. 170-183
Author(s):  
K. Šilink ◽  
J. Němec ◽  
J. Kubal ◽  
S. Röhling ◽  
S. Vohnout
Keyword(s):  
Bone Marrow ◽  
Thyroid Cancer ◽  
Radiation Injury ◽  
Clinical Course ◽  
External Irradiation ◽  
Bone Marrow Depression ◽  
Erythroid Hyperplasia ◽  
Cytological Features ◽  
Haematological Changes ◽  
Therapeutic Administration

SummaryThe clinical course and the haematologic events in a patient suffering from metastatic thyroid cancer after administration of 806 mCi of 131I are described. A serious bone marrow depression developed and was treated successfully. The haematological changes during the early and late phases of the radiation injury were studied in detail and compared with those after external irradiation. The haematological events after internal irradiation with 131I are characterised by initial neutrophilic leukocytosis, protracted lymphopenia, slowly developing anaemia reaching lowest values about 3 months after administration, erythroid hyperplasia in the bone marrow after recovery from bone marrow depression and prominent cytological features of the bone marrow, especially pronounced erythropoietic polyploidy.

Iron Metabolism in the Human Body and Setting its Hygienic Limits for Drinking Water. Review. Part 2

2020 ◽  
Vol 99 (5) ◽  
pp. 504-508
Author(s):  
Natalija A. Egorova ◽  
N. V. Kanatnikova
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Iron Overload ◽  
Iron Metabolism ◽  
Subcutaneous Tissue ◽  
Allergic Diseases ◽  
The Body ◽  
Urogenital System ◽  
High Iron Content ◽  
Labile Iron Pool

Iron is an assential element for the growth, division, differentiation and functioning of any cell in the body. Iron is virtually important for human and danger at the same time, because with excessive accumulation it causes oxidative stress with formation of highly active oxygen radicals and reactive form of nitrogen that can destroy cell membranes, proteins, nucleic acids, reduce cell viability, with, according to modern concepts, can contribute to the development of many diseases (cardiovascular, rheumatic, gastrointestinal, neurodegenerative, oncological, metabolic and others), and also accelerate the aging process. Part 1 of this review discussed the issues of iron metabolism in human, including its regulation at the cellular and systemic levels, the intake, transport, use, accumulation and export of iron in cells, the role of the labile iron pool in the cytoplasm of cells and plasma non-transferrin bound iron. Data are provided on the causes, frequency and significance of iron overload in the formation of free radicals and the development of oxidative stress. Part 2 of the review provides information on diseases associated with iron overload as well as information on ferroptosis - a new type of iron-dependent regulated cell death. Attention is paid to the works of domestic authors, where it was found that prolonged use of drinking water with a high iron content is unfavorable for the population and leads to an increase in the overall incidence, the development of the diseases of the blood, skin and subcutaneous tissue, musculoskeletal system, digestive system, urogenital system, and allergic diseases. Separate publications are cited on the possibility of a negative effect of iron at concentrations in water of 0.3 mg/l and lower. The material of the review emphasizes the preventive significance of caution attitude to regulating iron in the water in the Russian Federation, where 1/3 of the population uses iron-containing water for drinking, and substantiate the feasibility of establishing a hygienic limit for iron in water not higher than 0.3 mg/l.

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