Osteophytes and joint space narrowing are independently associated with pain in finger joints in hand osteoarthritis

2011 ◽  
Vol 70 (10) ◽  
pp. 1835-1837 ◽  
Author(s):  
Marion C Kortekaas ◽  
Wing-Yee Kwok ◽  
Monique Reijnierse ◽  
Tom W J Huizinga ◽  
Margreet Kloppenburg
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Joint Space Narrowing ◽  
Joint Space ◽  
Hand Osteoarthritis ◽  
X Rays ◽  
Finger Joints ◽  
Hand Joints ◽  
American College Of Rheumatology ◽  
Structural Abnormalities

ObjectiveTo study the associations between structural abnormalities on ultrasound (US) or conventional x-rays (CR) and pain in hand osteoarthritis (HOA).MethodsIn 55 consecutive patients with HOA (mean age 61 years, 86% women) fulfilling the American College of Rheumatology criteria, pain in 30 separate hand joints was assessed upon palpation; osteophytes were assessed by US and CR and joint space narrowing (JSN) by CR. Associations between structural abnormalities and pain per joint were analysed using generalised estimated equations to account for patient effects and adjusted for age, sex, body mass index, US inflammatory features and other remaining structural abnormalities.ResultsIn 1649 joints, 69% and 46% had osteophytes on US and CR, respectively and 47% had JSN. Osteophytes and JSN showed independent associations with pain per joint adjusted: OR for osteophytes: 4.8 (95% CI 3.1 to 7.5) for US and 4.1 (95% CI 2.4 to 7.1) for CR; for JSN: 4.2 (95% CI 2.0 to 9.0).ConclusionsOsteophytes and JSN are independently associated with pain in individual HOA joints, taking into account patient effects.

scholarly journals AB0867 INCREASED ADIPONECTIN LEVELS ARE ASSOCIATED WITH HIGHER RADIOGRAPHIC SCORES IN THE KNEE JOINT, BUT NOT IN THE HAND JOINT: THE DONG-GU STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1740.1-1740
Author(s):  
J. H. Kang ◽  
S. E. Choi ◽  
H. Xu ◽  
D. J. Park ◽  
S. S. Lee
Keyword(s):  
Body Mass Index ◽  
Knee Joint ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
Joint Space ◽  
Serum Adiponectin ◽  
Hand Osteoarthritis ◽  
X Rays ◽  
Subchondral Cyst ◽  
The Relationship

Background:Several studies have evaluated the association between serum adiponectin levels and knee and hand osteoarthritis (OA), with mixed results.Objectives:The aim of this study was to investigate the relationship between OA and serum adiponectin levels according to the radiographic features of knee and hand OA.Methods:A total of 2,402 subjects were recruited from the Dong-gu Study. Baseline characteristics were collected via a questionnaire, and X-rays of knee and hand joints were scored by a semi-quantitative grading system. The relationship between serum adiponectin levels and radiographic severity was evaluated by linear regression analysis.Results:Subjects with higher tertiles of serum adiponectin were older and had a lower body mass index than those with lower tertiles. In the knee joint scores, serum adiponectin levels were positively associated with the total score (P<0.001), osteophyte score (P=0.003), and joint space narrowing (JSN) score (P<0.001) among the three tertiles after adjustment for age, sex, body mass index, smoking, alcohol consumption, education, and physical activity. In the hand joint scores, no association was found between serum adiponectin levels and the total score, osteophyte score, JSN score, subchondral cyst score, sclerosis score, erosion score, and malalignment score among the three tertiles after adjustment.Conclusion:In this study, we found that increased adiponectin levels were associated with higher radiographic scores in the knee joint, but not in the hand joint, suggesting different pathophysiologic mechanisms in the development of OA.Disclosure of Interests:None declared

scholarly journals 395 OSTEOPHYTES AND JOINT SPACE NARROWING ARE INDEPENDENTLY ASSOCIATED WITH PAIN IN FINGER JOINTS IN HAND OSTEOARTHRITIS

2011 ◽  
Vol 19 ◽  
pp. S182-S183
Author(s):  
M. Kortekaas ◽  
W.-Y. Kwok ◽  
M. Reijnierse ◽  
T. Huizinga ◽  
M. Kloppenburg
Keyword(s):  
Joint Space Narrowing ◽  
Joint Space ◽  
Hand Osteoarthritis ◽  
Finger Joints

scholarly journals Increased adiponectin levels are associated with higher radiographic scores in the knee joint, but not in the hand joint

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Haimuzi Xu ◽  
Ji-Hyoun Kang ◽  
Sung-Eun Choi ◽  
Dong-Jin Park ◽  
Sun-Seog Kweon ◽  
...  
Keyword(s):  
Knee Joint ◽  
Joint Space ◽  
Knee Joints ◽  
Serum Adiponectin ◽  
Hand Osteoarthritis ◽  
X Rays ◽  
Hand Joints ◽  
Subchondral Cyst ◽  
Radiographic Score ◽  
The Relationship

AbstractSeveral studies have evaluated the association between serum adiponectin levels and knee and hand osteoarthritis (OA); mixed results have been reported. We investigated the relationship between OA and serum adiponectin levels according to the radiographic features of knee and hand OA. A total of 2402 subjects was recruited from the Dong-gu Study. Baseline characteristics were collected via a questionnaire, and X-rays of knee and hand joints were scored using a semi-quantitative grading system. The relationship between serum adiponectin levels and radiographic severity was evaluated by linear and logistic regression analysis. Subjects in the higher serum adiponectin levels tertiles were older and had a lower body mass index (BMI) than those in the lower tertiles. Regarding knee joint scores, serum adiponectin levels was positively associated with the total (P < 0.001), osteophyte (P = 0.003), and joint space narrowing (JSN) scores (P < 0.001) after adjustment for age, sex, BMI, smoking, alcohol consumption, education, and physical activity. In terms of hand joint scores, no association was found between serum adiponectin levels and the total, osteophyte, JSN, subchondral cyst, sclerosis, erosion, or malalignment score after the above-mentioned adjustments. Similarly, subjects with serum adiponectin levels above the median had higher total radiographic scores in the knee joints, but not in the hand joints, after adjustment. An increased serum adiponectin levels was associated with a higher radiographic score in the knee joint, but not in the hand joint, suggesting the involvement of different pathophysiologic mechanisms in the development of OA between those joints.

scholarly journals Relationship between Body Mass Index (BMI) and Knee Osteoarthritis at the UKI General Hospital, Jakarta in 2017

2021 ◽  
Vol 11 (10) ◽  
pp. 365-377
Author(s):  
Ronald Vinantius Munthe ◽  
Wendy Hendrika ◽  
Natasya Yoreskitha Gurusinga
Keyword(s):  
Body Mass Index ◽  
Knee Osteoarthritis ◽  
General Hospital ◽  
Body Mass ◽  
Joint Space Narrowing ◽  
Joint Space ◽  
Joint Disease ◽  
Key Words Knee ◽  
Cross Sectional ◽  
The Mean

Knee osteoarthritis is a degenerative joint disease usually suffered by elderly patients, contributing to the high risk of disability. The risk factors that affect the severity of knee osteoarthritis are obesity, age, sex, occupation, patient's history of the disease, trauma and other factors. Excessive body weight is a factor that exacerbates the disease of Osteoarthritis. Generally, this research is aimed to examine the correlation between Body Mass Index (BMI) and knee osteoarthritis at UKI General Hospital in 2017. The researcher used a descriptive-analytic study with a cross-sectional approach. In this study, the researcher used 30 samples. The results showed that there was a relationship between BMI and the incidence of knee osteoarthritis. This study indicates that BMI values above average (more than 24.9) can affect the occurrence of joint space narrowing in patients. Patients with abnormal BMI have a risk of 6,429 times the risk of joint space narrowing compared to patients with normal BMI. The mean BMI value of patients with knee osteoarthritis at UKI General Hospital is 25.6. Therefore, the researcher concluded that there is a correlation between BMI and knee osteoarthritis, in which a high BMI value (>24.9) may affect the occurrence of joint space narrowing among the patients. The mean BMI value among the osteoarthritis patients at UKI General Hospital is 25.6, indicating that most osteoarthritis patients are pre-obese/overweight. Key words: Knee osteoarthritis, Body Mass Index (BMI), joint space narrowing

scholarly journals Joint space narrowing, body mass index, and knee pain: the ROAD study (OAC1839R1)

2015 ◽  
Vol 23 (6) ◽  
pp. 874-881 ◽  
Author(s):  
S. Muraki ◽  
T. Akune ◽  
Y. En-yo ◽  
M. Yoshida ◽  
T. Suzuki ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Knee Pain ◽  
Joint Space Narrowing ◽  
Joint Space ◽  
The Road ◽  
Road Study

The demography of limb dominance, body-mass index, and metatarsus adductus deformity

1998 ◽  
Vol 88 (9) ◽  
pp. 429-436 ◽  
Author(s):  
JR Montague ◽  
M Bovarnick ◽  
SC Effren ◽  
CC Southerland
Keyword(s):  
Body Mass Index ◽  
Body Size ◽  
Body Mass ◽  
South Florida ◽  
X Rays ◽  
Statistical Association ◽  
Metatarsus Adductus ◽  
Average Body Mass ◽  
Average Body ◽  
Limb Dominance

To test the null hypothesis that limb dominance (laterality) and side of complaint are not associated in a diverse population, nearly 400 patients (40% male, 60% female) of varying age and body size from three South Florida podiatric medical teaching facilities were surveyed in 1995-1996. Radiographs of feet were available for 15% of the patients, and the metatarsus adductus angle was measured on each x-ray. The typical patient was a women (median age, 49 years) of average body weight and average body-mass index. No statistical association was found between laterality and side of complaint in the broader sample, although a significant association did appear in the subsample of patients with bilateral x-rays. The prevalence of metatarsus adductus deformity (metatarsus adductus angle &gt; 15 degrees) among patients with x-rays was 62%. No sex-specific, age-specific, or body size-specific associations were found between handedness and metatarsus adductus deformity.

scholarly journals Increased radiographic progression of distal hand osteoarthritis occurring during biologic DMARD monotherapy for concomitant rheumatoid arthritis

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
C. A. Lechtenboehmer ◽  
T. Burkard ◽  
S. Reichenbach ◽  
U. A. Walker ◽  
A. M. Burden ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Joint Space Narrowing ◽  
Radiographic Progression ◽  
Cox Regression ◽  
Joint Space ◽  
Estimating Equation ◽  
Considerable Proportion ◽  
Hand Osteoarthritis ◽  
Increased Risk ◽  
Subchondral Sclerosis

Abstract Objectives A considerable proportion of patients with rheumatoid arthritis (RA) also suffer from hand osteoarthritis (OA). We here assess the association between conventional synthetic (cs) and biological (b) disease-modifying antirheumatic drugs (DMARDs) and radiographic distal interphalangeal-(DIP) OA in patients with RA. Methods Adult RA patients from a longitudinal Swiss registry of rheumatic diseases who had ≥ 2 hand radiographs were included at the first radiograph and followed until the outcome or the last radiograph. Patients were grouped into two cohorts based on whether DIP OA was present or absent at cohort entry (cohorts 1 and 2, respectively). Modified Kellgren-Lawrence scores (KLS) were obtained by evaluating DIP joints for the severity of osteophytes, joint space narrowing, subchondral sclerosis, and erosions. KLS ≥ 2 in ≥ 1 DIP joint indicated incident or existing OA, and increase of ≥ 1 in KLS in ≥ 1 DIP joint indicated progression in existing DIP OA. Time-varying Cox regression and generalized estimating equation (GEE) analyses were performed. We estimated hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CI) of DIP OA incidence (cohort 2), or progression (cohort 1), in bDMARD monotherapy, bDMARD/csDMARD combination therapy, and past or never DMARD use, when compared to csDMARD use. In post hoc analyses, we descriptively and analytically assessed the individual KLS features in cohort 1. Results Among 2234 RA patients with 5928 radiographs, 1340 patients had DIP OA at baseline (cohort 1). Radiographic progression of DIP OA was characterized by new or progressive osteophyte formation (666, 52.4%), joint space narrowing (379, 27.5%), subchondral sclerosis (238, 17.8%), or erosions (62, 4.3%). bDMARD monotherapy had an increased risk of radiographic DIP OA progression compared to csDMARD monotherapy (adjusted HR 1.34 [95% CI 1.07–1.69]). The risk was not significant in csDMARD/bDMARD combination users (HR 1.12 [95% CI 0.96–1.31]), absent in past DMARD users (HR 0.96 [95% CI 0.66–1.41]), and significantly lower among never DMARD users (HR 0.54 [95% CI 0.33–0.90]). Osteophyte progression (HR 1.74 [95% CI 1.11–2.74]) was the most significantly increased OA feature with bDMARD use compared to csDMARD use. In 894 patients without initial DIP OA (cohort 2), the risk of incident OA did not differ between the treatment groups. The results from GEE analyses corroborated all findings. Conclusions These real-world RA cohort data indicate that monotherapy with bDMARDs is associated with increased radiographic progression of existing DIP OA, but not with incident DIP OA.

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