Urinary type II collagen C-terminal peptide is associated with synovitis and predicts structural bone loss in very early inflammatory arthritis

2010 ◽  
Vol 70 (2) ◽  
pp. 331-333 ◽  
Author(s):  
J. E. Freeston ◽  
P. Garnero ◽  
R. J. Wakefield ◽  
E. M. A. Hensor ◽  
P. G. Conaghan ◽  
...  
Keyword(s):  
Bone Loss ◽  
Inflammatory Arthritis ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Early Inflammatory Arthritis

scholarly journals Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: Relationship to mediators of systemic and local inflammation

2003 ◽  
Vol 48 (11) ◽  
pp. 3085-3095 ◽  
Author(s):  
Alexander Fraser ◽  
Ursula Fearon ◽  
R. Clark Billinghurst ◽  
Mirela Ionescu ◽  
Richard Reece ◽  
...  
Keyword(s):  
Inflammatory Arthritis ◽  
Type Ii Collagen ◽  
Cartilage Matrix ◽  
Type Ii ◽  
Local Inflammation

scholarly journals Early degradation of type IX and type II collagen with the onset of experimental inflammatory arthritis

2001 ◽  
Vol 44 (1) ◽  
pp. 120-127 ◽  
Author(s):  
Toshihisa Kojima ◽  
Fackson Mwale ◽  
Tadashi Yasuda ◽  
Christiane Girard ◽  
A. Robin Poole ◽  
...  
Keyword(s):  
Inflammatory Arthritis ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Early Degradation

Induction of bone loss in DBA/1J mice immunized with citrullinated autologous mouse type II collagen in the absence of adjuvant

2013 ◽  
Vol 58 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Anand Dusad ◽  
Michael J. Duryee ◽  
Anita T. Shaw ◽  
Lynell W. Klassen ◽  
Daniel R. Anderson ◽  
...  
Keyword(s):  
Bone Loss ◽  
Type Ii Collagen ◽  
Type Ii

Degradation of cartilage type II collagen in experimental inflammatory arthritis (EIA) may be prevented by CGP 42'446

Bone ◽  
1995 ◽  
Vol 17 (6) ◽  
pp. 598
Author(s):  
E.R. Bogoch ◽  
E.L. Moran ◽  
A.R. Reiner ◽  
A.R. Poole
Keyword(s):  
Inflammatory Arthritis ◽  
Type Ii Collagen ◽  
Type Ii

Early changes in serum type ii collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapy

2007 ◽  
Vol 56 (9) ◽  
pp. 2919-2928 ◽  
Author(s):  
Ronan H. Mullan ◽  
Clare Matthews ◽  
Barry Bresnihan ◽  
Oliver FitzGerald ◽  
Lindsay King ◽  
...  
Keyword(s):  
Inflammatory Arthritis ◽  
Radiographic Progression ◽  
Biologic Therapy ◽  
Type Ii Collagen ◽  
Type Ii ◽  
One Year ◽  
Serum Type

scholarly journals Disease activity and severity in early inflammatory arthritis predict hand cortical bone loss

Rheumatology ◽  
2010 ◽  
Vol 49 (10) ◽  
pp. 1943-1948 ◽  
Author(s):  
S. R. Pye ◽  
J. E. Adams ◽  
K. A. Ward ◽  
D. K. Bunn ◽  
D. P. M. Symmons ◽  
...  
Keyword(s):  
Bone Loss ◽  
Disease Activity ◽  
Cortical Bone ◽  
Inflammatory Arthritis ◽  
Cortical Bone Loss ◽  
Early Inflammatory Arthritis

Healing of Circular Defects in the Rabbit Medial Meniscus Can Occur Spontaneously and Is not Improved by Intra-Articular Hyaluronic Acid

1996 ◽  
Vol 09 (02) ◽  
pp. 60-5 ◽  
Author(s):  
N. Hope ◽  
P. Ghosh ◽  
S. Collier
Keyword(s):  
Hyaluronic Acid ◽  
Medial Meniscus ◽  
Chondroitin Sulphate ◽  
Rabbit Model ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Keratan Sulphate ◽  
Meniscal Healing ◽  
Meniscus Healing ◽  
Made In

SummaryThe aim of this study was to determine the effects of intra-articular hyaluronic acid on meniscal healing. Circular defects, 1.0 mm in diameter, were made in the anterior third of the medial meniscus in rabbits. In one joint, 0.4 ml hyaluronic acid (Healon®) was instilled, and in the contralateral (control) joint, 0.4 ml Ringer’s saline. Four rabbits were killed after four, eight and 12 weeks and the menisci examined histologically. By eight weeks most of the lesions had healed by filling with hyaline-like cartilage. Healing was not improved by hyaluronic acid treatment. The repair tissue stained strongly with alcian blue, and the presence of type II collagen, keratan sulphate, and chondroitin sulphate was demonstrated by immunohistochemical localisation. In contrast to the circular defects, longitudinal incisions made in the medial menisci of a further six rabbits did not show any healing after 12 weeks, indicating that the shape of the lesion largely determined the potential for healing.The effect of hyaluronic acid on meniscal healing was tested in a rabbit model. With one millimeter circular lesions in the medial meniscus, healing by filling with hyalinelike cartilage was not significantly affected by the application of hyaluronic acid intra-articularly at the time of surgery, compared to saline controls, as assessed histologically four, eight and 12 weeks after the operation.

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