Genetic polymorphisms of the matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases-1 (TIMP-1) modulate the development of ankylosing spondylitis

2008 ◽  
Vol 68 (11) ◽  
pp. 1781-1786 ◽  
Author(s):  
J C-C Wei ◽  
H-S Lee ◽  
W-C Chen ◽  
L-J Shiu ◽  
S-F Yang ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Genetic Polymorphisms ◽  
Tissue Inhibitors ◽  
Matrix Metalloproteinase 3 ◽  
The Matrix

scholarly journals The Serum Levels of Circulating Matrix Metalloproteinase MMP-9, MMP-2/TIMP-2 Complex and TIMP-1 do not Change Significantly During Normal Pregnancy.

2020 ◽  
Author(s):  
Ritva Nissi ◽  
Markku Santala ◽  
Anne Talvensaari-Mattila
Keyword(s):  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Plasma Levels ◽  
Statistical Significance ◽  
Serum Levels ◽  
Normal Pregnancy ◽  
Tissue Inhibitors ◽  
Time Points ◽  
Activity Measurements

Abstract Objective: Matrix metalloproteinases (MMPs) are important regulators of vascular and uterine remodeling. Normal pregnancy is associated with increased MMP activity. Measurements of the plasma levels on MMPs have not been consistent between studies in complicated pregnancies. We have examined MMP-9, MMP-2 and their respective tissue inhibitors TIMP-1 and TIMP-2 in different time points in the sera of 13 women with normal pregnancy. Results: The serum levels of MMP-9 and TIMP-1 were stable throughout pregnancy. The level of MMP-2/TIMP-2 complex was slightly increased after week 15 without statistical significance. The serum levels of MMP-9, MMP-2/TIMP-2 and TIMP-1 on different time points during normal pregnancy are poorly studied and further measurements of the plasma levels of MMPs and the correlation with MMP levels in the placenta and other maternal tissues are needed.

Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population

2004 ◽  
Vol 92 (10) ◽  
pp. 867-873 ◽  
Author(s):  
Xiaoyang Zhou ◽  
Jianfeng Huang ◽  
Jianhong Chen ◽  
Shaoyong Su ◽  
Runsheng Chen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Matrix Metalloproteinase ◽  
Promoter Polymorphism ◽  
Chinese Han Population ◽  
Healthy Controls ◽  
Chinese Han ◽  
Han Population ◽  
Matrix Metalloproteinase 3 ◽  
Increased Risk ◽  
The Matrix

SummaryMatrix metalloproteinase (MMP) 3 plays an important role in the pathogenesis of myocardial infarction (MI). Up to now, there has been conflicting data regarding the possible contribution of the MMP3 -1612 5A/6A promoter polymorphism to MI. In this study, we have investigated the possible association of three polymorphisms (-1612 5A/6A, -376C/G, Glu45Lys) in the MMP3 gene with MI in a Chinese Han population. The polymorphisms were analyzed in 509 patients with MI, and in 518 healthy controls. The frequency of the 5A allele was 14% in the healthy controls, which is less than in Western populations (40%-52%). Logistic regression analyses of individual polymorphisms indicated that individuals carrying the -1612 5A allele had an increased risk of MI (odds ratio [OR] 1.75, 95% confidence interval [CI] 1.28 to 2.40), as did those carrying the -376 G allele (OR 1.78, 95% CI 1.33 to 2.38). The three polymorphisms studied were found to be in strong linkage disequilibria. Haplotype analyses showed that the 5A-G-Lys haplotype (-1612 5A, -376G and 45Lys) was independently associated with susceptibility to MI. Taken together, the effect of the MMP3 polymorphisms studied may be attributable to the -1612 5A/6A polymorphism. We conclude that the MMP3 -1612 5A/6A polymorphism is associated with MI in our population, implying that individuals of the 5A allele carriers have an increased risk of suffering MI.

Common variants of the matrix metalloproteinase-3 (stromelysin) gene promoter in primary biliary cirrhosis

2002 ◽  
Vol 122 (1) ◽  
pp. 247-248 ◽  
Author(s):  
Carlo Selmi ◽  
Massimo Zuin ◽  
Francesca Meda ◽  
Mauro Podda ◽  
Maria Luisa Biondi ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Matrix Metalloproteinase ◽  
Gene Promoter ◽  
Biliary Cirrhosis ◽  
Common Variants ◽  
Matrix Metalloproteinase 3 ◽  
The Matrix
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