Neuropsychiatric syndromes in patients with systemic lupus erythematosus and primary Sjogren syndrome: a comparative population-based study

2008 ◽  
Vol 68 (10) ◽  
pp. 1541-1546 ◽  
Author(s):  
E Harboe ◽  
A B Tjensvoll ◽  
S Maroni ◽  
L G Goransson ◽  
O J Greve ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Population Based ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Systemic Lupus ◽  
Population Based Study ◽  
Primary Sjögren Syndrome ◽  
Comparative Population

Increased Frequency of Hand Osteoarthritis in Patients with Primary Sjögren Syndrome Compared with Systemic Lupus Erythematosus

2016 ◽  
Vol 43 (6) ◽  
pp. 1068-1071 ◽  
Author(s):  
Adem Aksoy ◽  
Dilek Solmaz ◽  
Gercek Can ◽  
Pinar Cetin ◽  
Ali Balci ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Daily Practice ◽  
Sjögren Syndrome ◽  
Controlled Study ◽  
Hand Osteoarthritis ◽  
Sjogren Syndrome ◽  
Systemic Lupus ◽  
Primary Sjögren Syndrome ◽  
The Mean

Objective.In daily practice, we noticed that hand osteoarthritis (OA) was commonly associated with primary Sjögren syndrome (pSS). Therefore, we aimed to investigate its prevalence in patients with pSS in a controlled study.Methods.The study included patients with pSS and controls with systemic lupus erythematosus (SLE). Standard hand/wrist radiographs were obtained and classified according to the Kellgren-Lawrence system. “Erosive hand OA” was defined according to the Verbruggen-Veys classification.Results.There were 114 patients with pSS (110 women, 51.0 yrs) and 34 patients with SLE (33 women, 42.4 yrs). Among 114 patients with pSS, 42.7% had radiographic, 30.3% symptomatic, and 16.0% erosive hand OA. The prevalences of radiographic (45.5%) and erosive hand OA (14.4%) in 90 patients with pSS with age- and sex-matched patients with SLE were significantly higher than those in patients with SLE (14.7% and 0.0%, p = 0.007 and p = 0.012, respectively). Interobserver reliabilities for diagnosing radiographic and erosive OA were found to be good (ĸ = 0.780 and ĸ = 0.788, respectively). Intraobserver reliabilities for diagnosing radiographic and erosive OA were also good (ĸ = 0.784 and ĸ = 0.825 for FO, and ĸ = 0.722 and ĸ = 0.800 for AB, respectively). The frequency of hand OA in patients with pSS was found to be increased with increasing age (r = 0.513). The mean age of those with erosive hand OA was significantly higher than those without erosive OA (p < 0.001).Conclusion.This study suggests that pSS, conversely to SLE, is more frequently associated with hand OA.

Sign in / Sign up

Export Citation Format

Share Document