scholarly journals B cell depletion therapy in systemic lupus erythematosus: long-term follow-up and predictors of response

2007 ◽  
Vol 66 (9) ◽  
pp. 1259-1262 ◽  
Author(s):  
K. P Ng ◽  
G. Cambridge ◽  
M. J Leandro ◽  
J. C W Edwards ◽  
M. Ehrenstein ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
B Cell ◽  
Lupus Erythematosus ◽  
Cell Depletion ◽  
B Cell Depletion ◽  
Systemic Lupus ◽  
Predictors Of Response ◽  
Long Term Follow Up

scholarly journals Long-term effects of combined B-cell immunomodulation with rituximab and belimumab in severe, refractory systemic lupus erythematosus: 2-year results

2020 ◽  
Author(s):  
Tineke Kraaij ◽  
Eline J Arends ◽  
Laura S van Dam ◽  
Sylvia W A Kamerling ◽  
Paul L A van Daele ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
B Cells ◽  
B Cell ◽  
Lupus Erythematosus ◽  
Cell Depletion ◽  
B Cell Depletion ◽  
Systemic Lupus ◽  
Anti Cd20

Abstract Background Anti-CD20 B-cell depletion has not shown superior efficacy to standard immunosuppression in patients with systemic lupus erythematosus (SLE). Besides trial design, potential explanations are incomplete B-cell depletion in relation to substantial surges in B-cell-activating factor (BAFF). To improve B-cell targeting strategies, we conducted the first study in SLE patients aimed at investigating immunological effects and feasibility of combining rituximab (RTX; anti-CD20) and belimumab (BLM; anti-BAFF). Methods Reported is the long-term follow-up of a Phase 2 proof-of-concept study in 15 patients with SLE including 12 (80%) with lupus nephritis (LN). Results In 10/15 (67%) patients, a clinical response was observed by achievement of lupus low disease activity state, of which 8 (53%) continued treatment (BLM + ≤7.5 mg prednisolone) for the complete 2 years of follow-up. Five patients (33%) were referred to as ‘non-responders’ due to persistent LN, major flare or repetitive minor flares. Out of 12 LN patients, 9 (75%) showed a renal response including 8 (67%) complete renal responders. All anti-dsDNA+ patients converted to negative, and both anti-C1q and extractable nuclear antigen autoantibodies showed significant reductions. CD19+ B cells showed a median decrease from baseline of 97% at 24 weeks, with a persistent reduction of 84% up to 104 weeks. When comparing responders with non-responders, CD20+ B cells were depleted significantly less in non-responders and double-negative (DN) B cells repopulated significantly earlier. Conclusions Combined B-cell targeted therapy with RTX and BLM prevented full B-cell repopulation including DN B cells, with concomitant specific reduction of SLE-relevant autoantibodies. The observed immunological and clinical benefits in a therapy-refractory SLE population prompt further studies on RTX + BLM.

B cell depletion therapy in systemic lupus erythematosus

2003 ◽  
Vol 5 (5) ◽  
pp. 350-356 ◽  
Author(s):  
Jennifer Anolik ◽  
Iñaki Sanz ◽  
R. John Looney
Keyword(s):  
Systemic Lupus Erythematosus ◽  
B Cell ◽  
Lupus Erythematosus ◽  
Cell Depletion ◽  
B Cell Depletion ◽  
Systemic Lupus

scholarly journals B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients

Rheumatology ◽  
2005 ◽  
Vol 44 (12) ◽  
pp. 1542-1545 ◽  
Author(s):  
M. J. Leandro ◽  
G. Cambridge ◽  
J. C. Edwards ◽  
M. R. Ehrenstein ◽  
D. A. Isenberg
Keyword(s):  
Systemic Lupus Erythematosus ◽  
B Cell ◽  
Longitudinal Analysis ◽  
Lupus Erythematosus ◽  
Cell Depletion ◽  
B Cell Depletion ◽  
Systemic Lupus
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