scholarly journals Lumbar disc degeneration: association between osteophytes, end-plate sclerosis and disc space narrowing

2007 ◽  
Vol 66 (3) ◽  
pp. 330-333 ◽  
Author(s):  
S. R Pye ◽  
D. M Reid ◽  
M. Lunt ◽  
J. E Adams ◽  
A. J Silman ◽  
...  
Keyword(s):  
Disc Degeneration ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration ◽  
Disc Space Narrowing ◽  
Disc Space ◽  
End Plate

scholarly journals Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects

2012 ◽  
Vol 72 (7) ◽  
pp. 1141-1148 ◽  
Author(s):  
Frances M K Williams ◽  
Aruna T Bansal ◽  
Joyce B van Meurs ◽  
Jordana T Bell ◽  
Ingrid Meulenbelt ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Disc Degeneration ◽  
Lumbar Disc ◽  
Meta Analysis ◽  
Low Back ◽  
Lumbar Disc Degeneration ◽  
Disc Space Narrowing ◽  
Disc Space ◽  
Genome Wide

ObjectiveLumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. To date, the agnostic search of the genome by genome-wide association (GWA) to identify common variants associated with LDD has not been fruitful. This study is the first GWA meta-analysis of LDD.MethodsWe have developed a continuous trait based on disc space narrowing and osteophytes growth which is measurable on all forms of imaging (plain radiograph, CT scan and MRI) and performed a meta-analysis of five cohorts of Northern European extraction each having GWA data imputed to HapMap V.2.ResultsThis study of 4600 individuals identified four single nucleotide polymorphisms with p<5×10−8, the threshold set for genome-wide significance. We identified a variant in the PARK2 gene (p=2.8×10−8) associated with LDD. Differential methylation at one CpG island of the PARK2 promoter was observed in a small subset of subjects (β=8.74×10−4, p=0.006).ConclusionsLDD accounts for a considerable proportion of low back pain and the pathogenesis of LDD is poorly understood. This work provides evidence of association of the PARK2 gene and suggests that methylation of the PARK2 promoter may influence degeneration of the intervertebral disc. This gene has not previously been considered a candidate in LDD and further functional work is needed on this hitherto unsuspected pathway.

Lumbar Disc Degeneration in Osteoporotic Men: Prevalence and Assessment of the Relation with Presence of Vertebral Fracture

2013 ◽  
Vol 40 (7) ◽  
pp. 1183-1190 ◽  
Author(s):  
Isabelle Fabreguet ◽  
Jacques Fechtenbaum ◽  
Karine Briot ◽  
Simon Paternotte ◽  
Christian Roux
Keyword(s):  
Vertebral Fracture ◽  
Disc Degeneration ◽  
Vertebral Fractures ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration ◽  
Disc Space Narrowing ◽  
Disc Space ◽  
Spine Degeneration ◽  
The Relationship ◽  
Semiquantitative Method

Objective.The relationship between osteoarthritis (OA) and osteoporosis (OP) remains controversial. An inverse relationship between spine OA and the presence of prevalent vertebral fractures has been shown in osteoporotic women. Our objective was to assess this relationship in osteoporotic men.Methods.All the patients had OP based on densitometric data and were aged ≥ 65 years. Spine radiographs were performed according to a standardized procedure. Vertebral fractures were assessed from T4 to L4 by a semiquantitative method. Disc degenerative changes were assessed by the presence and severity of osteophytes and disc narrowing at levels T12–L1 to L5–S1. Logistic regression was used to study the relationship between the presence of vertebral fracture and lumbar disc degeneration.Results.The study included 261 osteoporotic men. The prevalence of vertebral fractures was 26.4% (69/261). At least 1 osteophyte was found in 91.6% (239/261) of patients, and at least 1 disc space narrowing in 63.5% (165/260). The prevalence of at least 1 osteophyte and/or at least 1 disc space narrowing was similar in patients with and those without vertebral fracture. No relationship was found between the presence and/or the severity of osteophytes and disc narrowings and the presence of prevalent vertebral radiographic fractures.Conclusion.In osteoporotic men, the prevalence of lumbar spine degeneration is high. There is no relationship between lumbar disc degeneration and the presence of vertebral fracture in osteoporotic men.

scholarly journals Evaluation of Cartilaginous End Plate and Annulus Fibrosus in Lumbar Disc Degeneration using OFF Resonant Saturation Ratios Assessed by a 3D Ultra Short Echo Time Sequence at 3 Tesla

2015 ◽  
Vol 5 (1_suppl) ◽  
pp. s-0035-1554394-s-0035-1554394
Author(s):  
Harry Gebhard ◽  
Petros Martirosian ◽  
Fabian Springer ◽  
Ulrich Grosse ◽  
Fritz Schick ◽  
...  
Keyword(s):  
Disc Degeneration ◽  
Annulus Fibrosus ◽  
Lumbar Disc ◽  
Time Sequence ◽  
3 Tesla ◽  
Lumbar Disc Degeneration ◽  
End Plate ◽  
Echo Time ◽  
Short Echo Time

Lumbar Disc Degeneration

1990 ◽  
Vol 31 (6) ◽  
pp. 551-554
Author(s):  
O. Tervonen ◽  
S. Lahde ◽  
J. Rydberg
Keyword(s):  
Disc Degeneration ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration

INTERVERTEBRAL DISC DEGENERATION LINKED TO STRUCTURAL GENE VARIATIONS

2019 ◽  
Author(s):  
Saeeda Baig
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
English Language ◽  
Tandem Repeats ◽  
Lumbar Disc ◽  
Disease Process ◽  
Nucleotide Polymorphisms ◽  
Structural Protein ◽  
Lumbar Disc Degeneration

During the recent past focus has shifted from identifying intervertebral disc degeneration as being caused by physical exposure and strain to being linked with a variety of genetic variations. The objective of this review is to provide an up to date review of the existing research data regarding the relation of intervertebral disc degeneration to structural protein genes and their polymorphisms and thus help clearly establish further avenues where research into causation and treatment is needed. A comprehensive search using the keywords “Collagen”, “COL”, “Aggrecan”, “AGC”, “IVDD”, “intervertebral disc degeneration”, and “lumbar disc degeneration” from PubMed and Google Scholar, where literature in the English language was selected spanning from 1991 to 2019. There are many genes involved in the production of structural components of an intervertebral disc. The issues in production of these components involve the over-expression or under-expression of their genes, and single nucleotide polymorphisms and variable number of tandem repeats affecting their structures. These structural genes include primarily the collagen and the aggrecan genes. While genetic and environmental factors all come into play with a disease process like disc degeneration, the bulk of research now shows the significantly larger impact of hereditary over exposure. While further research is needed into some of the lesser studied genes linked to IVDD and also the racial variations in genetic makeup, the focus in the near future should be on establishment of genetic testing to identify individuals at greater risk of disease and deliberation regarding the use of gene therapy to prevent disc degeneration.

Grading lumbar disc degeneration: a comparison between low- and high-field MRI

2019 ◽  
Vol 60 (12) ◽  
pp. 1636-1642 ◽  
Author(s):  
Bjarke B Hansen ◽  
Urszula M Ciochon ◽  
Charlotte R Trampedach ◽  
Anders F Christensen ◽  
Zoreh Rasti ◽  
...  
Keyword(s):  
Disc Degeneration ◽  
High Field ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration ◽  
High Field Mri
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