scholarly journals Arthritis instantaneously causes collagen type I and type II degradation in patients with early rheumatoid arthritis: a longitudinal analysis

2006 ◽  
Vol 65 (1) ◽  
pp. 40-44 ◽  
Author(s):  
R B M Landewe
Keyword(s):  
Rheumatoid Arthritis ◽  
Early Rheumatoid Arthritis ◽  
Longitudinal Analysis ◽  
Collagen Type ◽  
Collagen Type I ◽  
Type I ◽  
Type Ii

scholarly journals Antibodies Isolated from Rheumatoid Arthritis Patients against Lysine-Containing Proteus mirabilis O3 (S1959) Lipopolysaccharide May React with Collagen Type I

2020 ◽  
Vol 21 (24) ◽  
pp. 9635
Author(s):  
Katarzyna Durlik-Popińska ◽  
Paulina Żarnowiec ◽  
Łukasz Lechowicz ◽  
Józef Gawęda ◽  
Wiesław Kaca
Keyword(s):  
Rheumatoid Arthritis ◽  
Collagen Type ◽  
Collagen Type I ◽  
Attenuated Total Reflection ◽  
Antibody Activity ◽  
Type I ◽  
Dot Blot ◽  
Healthy Donors ◽  
Carbohydrate Components ◽  
Synthetic Antigens

Most rheumatic diseases, including rheumatoid arthritis (RA), are characterized by immune disorders that affect antibody activity. In the present study, using Dot blot and ELISA assay, we showed that patients with rheumatic disease produced significantly more antibodies against lipopolysaccharide (LPS) P. mirabilis O3 compared to healthy donors (p < 0.05), and affinity purified antibodies against LPS O3 may cross-react with collagen type I. It was demonstrated that purified of antibodies isolated from RA patients sera, reacted stronger with the collagen than healthy donors (p = 0.015), and cross-reaction was correlated with level of anti-citrullinated peptide antibodies (r = 0.7, p = 0.003). Moreover, using six different lipopolysaccharides were demonstrated the significant correlations in sera reactivity among lysine-containing lipopolysaccharides observed in patients’ sera (p < 0.05). Using Attenuated Total Reflection Fourier Transform Infrared Spectroscopy (ATR-FTIR) it was shown that unique wavenumbers of sera spectra correlate with reactivity with lipopolysaccharides allowing distinguish patients from healthy blood donors. Antibodies adsorption by synthetic antigens shows that in patients’ group anti-LPS O3 antibodies can be adsorbed by both amides of galacturonic acid and lysine or threonine, which suggests less specificity of antibodies binding with non-carbohydrate LPS component. The observed correlations suggest that non-carbohydrate components of LPS may be an important epitope for less specific anti-LPS antibodies, which might lead to cross-reactions and affect disease development.

Limb bud mesenchyme cultured under tensile strain remodel collagen type I tubes to produce fibrillar collagen type II

Biorheology ◽  
2009 ◽  
Vol 46 (6) ◽  
pp. 439-450 ◽  
Author(s):  
Jennifer R. Amos ◽  
Shigeng Li ◽  
Michael Yost ◽  
Harry Phloen ◽  
Jay D. Potts
Keyword(s):  
Tensile Strain ◽  
Collagen Type ◽  
Collagen Type I ◽  
Limb Bud ◽  
Type I ◽  
Fibrillar Collagen ◽  
Type Ii ◽  
Collagen Type Ii

scholarly journals Maintenance of chondrocyte phenotype during expansion on PLLA microtopographies

2018 ◽  
Vol 9 ◽  
pp. 204173141878982 ◽  
Author(s):  
Elisa Costa ◽  
Cristina González-García ◽  
José Luis Gómez Ribelles ◽  
Manuel Salmerón-Sánchez
Keyword(s):  
Lactic Acid ◽  
Type I Collagen ◽  
Collagen Type ◽  
Articular Chondrocytes ◽  
Collagen Type I ◽  
Cell Phenotype ◽  
Type I ◽  
Type Ii ◽  
Collagen Type Ii ◽  
Chondrocyte Phenotype

Articular chondrocytes are difficult to grow, as they lose their characteristic phenotype following expansion on standard tissue culture plates. Here, we show that culturing them on surfaces of poly(L-lactic acid) of well-defined microtopography allows expansion and maintenance of characteristic chondrogenic markers. We investigated the dynamics of human chondrocyte dedifferentiation on the different poly(L-lactic acid) microtopographies by the expression of collagen type I, collagen type II and aggrecan at different culture times. When seeded on poly(L-lactic acid), chondrocytes maintained their characteristic hyaline phenotype up to 7 days, which allowed to expand the initial cell population approximately six times without cell dedifferentiation. Maintenance of cell phenotype was afterwards correlated to cell adhesion on the different substrates. Chondrocytes adhesion occurs via the α5 β1 integrin on poly(L-lactic acid), suggesting cell–fibronectin interactions. However, α2 β1 integrin is mainly expressed on the control substrate after 1 day of culture, and the characteristic chondrocytic markers are lost (collagen type II expression is overcome by the synthesis of collagen type I). Expanding chondrocytes on poly(L-lactic acid) might be an effective solution to prevent dedifferentiation and improving the number of cells needed for autologous chondrocyte transplantation.

Limb bud mesenchyme cultured under tensile strain remodel collagen type I tubes to produce fibrillar collagen type II

Biorheology ◽  
2010 ◽  
Vol 47 (2) ◽  
pp. 163-163
Author(s):  
Jennifer R. Amos ◽  
Shigeng Li ◽  
Michael Yost ◽  
Harry Phloen ◽  
Jay D. Potts
Keyword(s):  
Tensile Strain ◽  
Collagen Type ◽  
Collagen Type I ◽  
Limb Bud ◽  
Type I ◽  
Fibrillar Collagen ◽  
Type Ii ◽  
Collagen Type Ii

scholarly journals Light and electron microscopicin situhybridization of collagen type I and type II mRNA in the fibrocartilaginous tissue of late-stage osteoarthritis

1998 ◽  
Vol 6 (4) ◽  
pp. 278-285 ◽  
Author(s):  
Nicolai Miosge ◽  
Kai Waletzko ◽  
Christa Bode ◽  
Fabio Quondamatteo ◽  
Wolfgang Schultz ◽  
...  
Keyword(s):  
Late Stage ◽  
Collagen Type ◽  
Collagen Type I ◽  
Type I ◽  
Type Ii

Optimization of Histoprocessing Methods to Detect Glycosaminoglycan, Collagen Type II, and Collagen Type I in Decalcified Rabbit Osteochondral Sections

2005 ◽  
Vol 28 (3) ◽  
pp. 165-175 ◽  
Author(s):  
Anik Chevrier ◽  
Evgeny Rossomacha ◽  
Michael D. Buschmann ◽  
Caroline D. Hoemann
Keyword(s):  
Collagen Type ◽  
Collagen Type I ◽  
Type I ◽  
Type Ii ◽  
Collagen Type Ii

Characteristics of cellular immune responses to collagen type I or collagen type II

1986 ◽  
Vol 100 (2) ◽  
pp. 314-330 ◽  
Author(s):  
L. Butler ◽  
B. Simmons ◽  
J. Zimmermann ◽  
P. DeRiso ◽  
K. Phadke
Keyword(s):  
Immune Responses ◽  
Collagen Type ◽  
Collagen Type I ◽  
Type I ◽  
Type Ii ◽  
Collagen Type Ii ◽  
Cellular Immune Responses ◽  
Cellular Immune
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