scholarly journals Inhibition of TNF  during maturation of dendritic cells results in the development of semi-mature cells: a potential mechanism for the beneficial effects of TNF  blockade in rheumatoid arthritis

2004 ◽  
Vol 64 (3) ◽  
pp. 408-414 ◽  
Author(s):  
A W T van Lieshout
Keyword(s):  
Rheumatoid Arthritis ◽  
Dendritic Cells ◽  
Potential Mechanism ◽  
Beneficial Effects

AB0133 Role of Monocytes Subsets in the Atherothrombosis and Endothelial Dysfunction Associated with Rheumatoid Arthritis: Beneficial Effects of Tocilizumab

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 935.2-935
Author(s):  
N. Barbarroja ◽  
P. Ruiz-Limon ◽  
C. Perez-Sanchez ◽  
Y. Jimenez-Gomez ◽  
M. Abalos-Aguilera ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Dysfunction ◽  
Beneficial Effects

scholarly journals Tocilizumab for the Treatment of Rheumatoid Arthritis and Other Systemic Autoimmune Diseases: Current Perspectives and Future Directions

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Atsushi Ogata ◽  
Toshio Tanaka
Keyword(s):  
Rheumatoid Arthritis ◽  
Autoimmune Diseases ◽  
Host Defense ◽  
Lupus Erythematosus ◽  
Therapeutic Strategy ◽  
Case Reports ◽  
Systemic Autoimmune Diseases ◽  
Future Directions ◽  
Pilot Studies ◽  
Beneficial Effects

Interleukin (IL)-6 is a cytokine featuring redundancy and pleiotropic activity. While IL-6, when transiently produced, contributes to host defense against acute environmental stress, continuous dysregulated IL-6 production plays a significant pathological role in several systemic autoimmune diseases. In response to the expectation that IL-6 blockade would constitute a novel therapeutic strategy for the treatment of these diseases, tocilizumab, a humanized anti-IL-6 receptor antibody, was developed. Clinical trials have verified the efficacy and the safety of tocilizumab for patients with rheumatoid arthritis, resulting in approval of this innovative biologic for the treatment of rheumatoid arthritis in more than 90 countries worldwide. Pathological analyses of the effect of IL-6 on the development of autoimmune diseases and a considerable number of case reports and pilot studies have also indicated the beneficial effects of this antibody on other systemic autoimmune diseases, including systemic lupus erythematosus, systemic sclerosis, polymyositis, and large-vessel vasculitis.

scholarly journals How Does Household Income Affect Child Personality Traits and Behaviors?

2018 ◽  
Vol 108 (3) ◽  
pp. 775-827 ◽  
Author(s):  
Randall Akee ◽  
William Copeland ◽  
E. Jane Costello ◽  
Emilia Simeonova
Keyword(s):  
Longitudinal Data ◽  
Personality Traits ◽  
Behavioral Health ◽  
Household Income ◽  
Potential Mechanism ◽  
Income Transfer ◽  
Parental Relationships ◽  
Beneficial Effects ◽  
Quasi Experimental ◽  
Emotional And Behavioral Health

We examine the effects of a quasi-experimental unconditional household income transfer on child emotional and behavioral health and personality traits. Using longitudinal data, we find that there are large beneficial effects on children's emotional and behavioral health and personality traits during adolescence. We find evidence that these effects are most pronounced for children who start out with the lowest initial endowments. The income intervention also results in improvements in parental relationships which we interpret as a potential mechanism behind our findings. (JEL D14, I12, I26, I31, I38, J13, J15)

Gut microbiota mediated the protective effects of tuna oil on collagen-induced arthritis in mice

2021 ◽  
Author(s):  
Chenyang Lu ◽  
Ju Chen ◽  
Congmin Yi ◽  
Jiaojiao Han ◽  
Qiuyue Shi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Autoimmune Disease ◽  
Gut Microbiota ◽  
Protective Effects ◽  
Collagen Induced Arthritis ◽  
Tuna Oil ◽  
Beneficial Effects ◽  
Chronic Autoimmune Disease

Rheumatoid arthritis is emerging as a chronic autoimmune disease worldwide. In this study, the components of tuna oil (TO) were firstly measured, and the beneficial effects of TO on collagen-induced...

scholarly journals SAT0022 THE SUBPOPULATION FEATURES OF DENDRITIC CELLS AS A POTENTIAL BIOMARKER OF EARLY RHEUMATOID ARTHRITIS

2019 ◽  
Author(s):  
Maxim Korolev ◽  
Yuliya Kurochkina ◽  
Nadezda Banshhikova ◽  
Vitaly Omelchenko ◽  
Anna Akimova ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Dendritic Cells ◽  
Early Rheumatoid Arthritis ◽  
Potential Biomarker

scholarly journals Dendritic cells, T cells and their interaction in rheumatoid arthritis

2019 ◽  
Vol 196 (1) ◽  
pp. 12-27 ◽  
Author(s):  
P. Wehr ◽  
H. Purvis ◽  
S.‐C. Law ◽  
R. Thomas
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Dendritic Cells
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