scholarly journals Long term high intensity exercise and damage of small joints in rheumatoid arthritis

2004 ◽  
Vol 63 (11) ◽  
pp. 1399-1405 ◽  
Author(s):  
Z de Jong
Keyword(s):  
Rheumatoid Arthritis ◽  
High Intensity ◽  
High Intensity Exercise

Cost-utility and cost-effectiveness analyses of a long-term, high-intensity exercise program compared with conventional physical therapy in patients with rheumatoid arthritis

2005 ◽  
Vol 53 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Wilbert B. van den Hout ◽  
Zuzana de Jong ◽  
Marten Munneke ◽  
Johanna M. W. Hazes ◽  
Ferdinand C. Breedveld ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cost Effectiveness ◽  
Physical Therapy ◽  
High Intensity ◽  
Exercise Program ◽  
Cost Utility ◽  
High Intensity Exercise

scholarly journals Is a long-term high-intensity exercise program effective and safe in patients with rheumatoid arthritis?: Results of a randomized controlled trial

2003 ◽  
Vol 48 (9) ◽  
pp. 2415-2424 ◽  
Author(s):  
Zuzana de Jong ◽  
Marten Munneke ◽  
Aeilko H. Zwinderman ◽  
Herman M. Kroon ◽  
Annemarie Jansen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Randomized Controlled Trial ◽  
High Intensity ◽  
Controlled Trial ◽  
Exercise Program ◽  
High Intensity Exercise ◽  
Randomized Controlled

scholarly journals Long-term follow-up of a high-intensity exercise program in patients with rheumatoid arthritis

2009 ◽  
Vol 28 (6) ◽  
pp. 663-671 ◽  
Author(s):  
Zuzana de Jong ◽  
Marten Munneke ◽  
Herman M. Kroon ◽  
Dirkjan van Schaardenburg ◽  
Ben A. C. Dijkmans ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
High Intensity ◽  
Exercise Program ◽  
High Intensity Exercise ◽  
Long Term Follow Up

scholarly journals Slowing of bone loss in patients with rheumatoid arthritis by long-term high-intensity exercise: Results of a randomized, controlled trial

2004 ◽  
Vol 50 (4) ◽  
pp. 1066-1076 ◽  
Author(s):  
Zuzana de Jong ◽  
Marten Munneke ◽  
Willem F. Lems ◽  
Aeilko H. Zwinderman ◽  
Herman M. Kroon ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Randomized Controlled Trial ◽  
Bone Loss ◽  
High Intensity ◽  
Controlled Trial ◽  
High Intensity Exercise ◽  
Randomized Controlled

scholarly journals Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Sofia E. M. Andersson ◽  
Elvira Lange ◽  
Daniel Kucharski ◽  
Sara Svedlund ◽  
Karin Önnheim ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Older Adults ◽  
Muscle Strength ◽  
High Intensity ◽  
Intervention Group ◽  
High Intensity Exercise ◽  
Cell Populations ◽  
Control Group ◽  
Regulatory Cells ◽  
Active Control Group

Abstract Objective Exercise can improve immune health and is beneficial for physical function in patients with rheumatoid arthritis (RA), but the immunological mechanisms are largely unknown. We evaluated the effect of moderate- to high intensity exercise with person-centred guidance on cells of the immune system, with focus on regulatory cell populations, in older adults with RA. Methods Older adults (≥65 years) with RA were randomized to either 20-weeks of moderate – to high intensity aerobic and resistance exercise (n = 24) or to an active control group performing home-based exercise of light intensity (n = 25). Aerobic capacity, muscle strength, DAS28 and CRP were evaluated. Blood samples were collected at baseline and after 20 weeks. The frequency of immune cells defined as adaptive regulatory populations, CD4 + Foxp3 + CD25 + CD127- T regulatory cells (Tregs) and CD19 + CD24hiCD38hi B regulatory cells (Bregs) as well as HLA-DR−/lowCD33 + CD11b + myeloid derived suppressor cells (MDSCs), were assessed using flow cytometry. Results After 20 weeks of moderate- to high intensity exercise, aerobic capacity and muscle strength were significantly improved but there were no significant changes in Disease Activity Score 28 (DAS28) or CRP. The frequency of Tregs and Bregs decreased significantly in the intervention group, but not in the active control group. The exercise intervention had no effect on MDSCs. The reduction in regulatory T cells in the intervention group was most pronounced in the female patients. Conclusion Moderate- to high intensity exercise in older adults with RA led to a decreased proportion of Tregs and Bregs, but that was not associated with increased disease activity or increased inflammation. Trial registration Improved Ability to Cope With Everyday Life Through a Person-centered Training Program in Elderly Patients With Rheumatoid Arthritis - PEP-walk Study, NCT02397798. Registered at ClinicalTrials.gov March 19, 2015.

Long-term effects of high-intensity exercise training in patients with COPD: a controlled study

2019 ◽  
Author(s):  
Tobias Boeselt ◽  
Christoph Nell ◽  
Lea Lütteken ◽  
Martina Veith ◽  
Bjoern Beutel ◽  
...  
Keyword(s):  
Exercise Training ◽  
High Intensity ◽  
High Intensity Exercise ◽  
Controlled Study ◽  
Long Term Effects

Differences among lower leg muscles in long-term activity during ambulatory condition without any moderate to high intensity exercise

2009 ◽  
Vol 19 (2) ◽  
pp. e50-e56 ◽  
Author(s):  
Hatuki Shirasawa ◽  
Hiroaki Kanehisa ◽  
Motoki Kouzaki ◽  
Kei Masani ◽  
Tetsuo Fukunaga
Keyword(s):  
High Intensity ◽  
Lower Leg ◽  
High Intensity Exercise ◽  
Leg Muscles

scholarly journals Moderate-to-high intensity exercise with person-centered guidance influences fatigue in older adults with rheumatoid arthritis

2019 ◽  
Vol 39 (9) ◽  
pp. 1585-1594 ◽  
Author(s):  
Daniel Kucharski ◽  
Elvira Lange ◽  
Alastair B. Ross ◽  
Sara Svedlund ◽  
Caroline Feldthusen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Older Adults ◽  
High Intensity ◽  
High Intensity Exercise

scholarly journals High intensity exercise during breast cancer chemotherapy - effects on long-term myocardial damage and physical capacity - data from the OptiTrain RCT

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Josefin Ansund ◽  
Sara Mijwel ◽  
Kate A. Bolam ◽  
Renske Altena ◽  
Yvonne Wengström ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Intensity ◽  
Troponin T ◽  
Interval Training ◽  
High Intensity Exercise ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Post Intervention ◽  
High Intensity Interval

Abstract Background Adjuvant systemic breast cancer treatment improves disease specific outcomes, but also presents with cardiac toxicity. In this post-hoc exploratory analysis of the OptiTrain trial, the effects of exercise on cardiotoxicity were monitored by assessing fitness and biomarkers over the intervention and into survivorship. Methods; Women starting chemotherapy were randomized to 16-weeks of resistance and high-intensity interval training (RT-HIIT), moderate-intensity aerobic and high-intensity interval training (AT–HIIT), or usual care (UC). Outcome measures included plasma troponin-T (cTnT), Nt-pro-BNP and peak oxygen uptake (VO2peak), assessed at baseline, post-intervention, and at 1- and 2-years. Results For this per-protocol analysis, 88 women met criteria for inclusion. Plasma cTnT increased in all groups post-intervention. At the 1-year follow-up, Nt-pro-BNP was lower in the exercise groups compared to UC. At 2-years there was a drop in VO2peak for patients with high cTnT and Nt-pro-BNP. Fewer patients in the RT-HIIT group fulfilled biomarker risk criteria compared to UC (OR 0.200; 95% CI = 0.055–0.734). Conclusions In this cohort, high-intensity exercise was associated with lower levels of NT-proBNP 1-year post-baseline, but not with cTnT directly after treatment completion. This may, together with the preserved VO2peak in patients with low levels of biomarkers, indicate a long-term cardioprotective effect of exercise. Trial registration Clinicaltrials.govNCT02522260, Registered 13th of august 2015 – Retrospectively Registered Graphical abstract

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