Acupuncture after Alcohol Consumption: A Sham Controlled Assessment

1996 ◽  
Vol 14 (2) ◽  
pp. 63-67 ◽  
Author(s):  
Heidi Thorer ◽  
Nadia Volf
Keyword(s):  
Body Weight ◽  
Alcohol Consumption ◽  
Healthy Volunteers ◽  
Alcohol Intoxication ◽  
Acupuncture Point ◽  
Clinical Effects ◽  
Blood Alcohol ◽  
Measurable Effect ◽  
Clinical Measurement ◽  
Sham Point

The effects of two different traditional acupuncture point combinations and a sham point were compared in 35 healthy volunteers 20 minutes and 2 hours after a single draught of 40% alcohol (1ml/kg body weight). Clinical measurement, using tests of equilibrium and orientation, and specific tests of the metabolism and elimination of alcohol, formed the basis of this comparison. The results are statistically significant (P<0.05). A needle in the sham point produced no measurable effect compared to the non acupuncture control. After both traditional acupuncture point combinations, observing all the measured parameters, the clinical effects of alcohol intoxication were minimised, while the alcohol level in the expired air was increased and the blood alcohol decreased.

scholarly journals Effects of binge alcohol consumption on sleep and inflammation in healthy volunteers

2018 ◽  
Vol 46 (9) ◽  
pp. 3938-3947 ◽  
Author(s):  
Amanda N. Wilkinson ◽  
Majid Afshar ◽  
Osman Ali ◽  
Waqas Bhatti ◽  
Jeffrey D. Hasday ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Healthy Volunteers ◽  
Ex Vivo ◽  
Interleukin 2 ◽  
Sleep Disruption ◽  
Blood Alcohol ◽  
Alcohol Content ◽  
Blood Alcohol Content ◽  
Ifn Γ ◽  
The Mean

Objective Alcohol is a hypnotic that modifies immune function, specifically the cytokines interferon gamma (IFN-γ) and interleukin 2 (IL-2). We evaluated the association between unscheduled napping and acute alcohol-induced augmentation of IFN-γ and IL-2 expression. Methods In this prospective, observational pilot study, volunteers completed questionnaires on sleep quality, alcohol use, and hangover characteristics. Actigraph recordings began three nights before and continued for four nights after study initiation. Napping was recorded by actigraphy and self-reporting. A weight-based dose of 100-proof vodka was consumed, and the blood alcohol content (BAC) and phytohemagglutinin-M stimulated cytokine level were measured before and 20 minutes, 2 hours, and 5 hours after binge consumption. Results Ten healthy volunteers participated (mean age, 34.4 ± 2.3 years; mean body mass index, 23.9 ± 4.6 kg/m2; 60% female). The mean 20-minute BAC was 137.7 ± 40.7 mg/dL. Seven participants took an unscheduled nap. The ex vivo IFN-γ and IL-2 levels significantly increased at all time points after binge consumption in the nappers, but not in the non-nappers. Conclusion Augmented IFN-γ and IL-2 levels are associated with unscheduled napping after binge alcohol consumption. Further studies are needed to clarify the associations among alcohol consumption, sleep disruption, and inflammatory mediators.

scholarly journals Acute alcohol consumption increases systemic endotoxin bioactivity for days in healthy volunteers—with reduced intestinal barrier loss in female

2021 ◽  
Author(s):  
Ramona Sturm ◽  
Florian Haag ◽  
Andrea Janicova ◽  
Baolin Xu ◽  
Jan Tilmann Vollrath ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Healthy Volunteers ◽  
Alcohol Drinking ◽  
Barrier Function ◽  
Tissue Injury ◽  
Alcohol Intoxication ◽  
Blood Alcohol Concentration ◽  
Intestinal Barrier ◽  
Fatty Acid Binding ◽  
Serum And Urine

Abstract Objective Trauma is the most common cause of death among young adults. Alcohol intoxication plays a significant role as a cause of accidents and as a potent immunomodulator of the post-traumatic response to tissue injury. Polytraumatized patients are frequently at risk to developing infectious complications, which may be aggravated by alcohol-induced immunosuppression. Systemic levels of integral proteins of the gastrointestinal tract such as syndecan-1 or intestinal fatty acid binding proteins (FABP-I) reflect the intestinal barrier function. The exact impact of acute alcohol intoxication on the barrier function and endotoxin bioactivity have not been clarified yet. Methods 22 healthy volunteers received a precisely defined amount of alcohol (whiskey–cola) every 20 min over a period of 4 h to reach the calculated blood alcohol concentration (BAC) of 1‰. Blood samples were taken before alcohol drinking as a control, and after 2, 4, 6, 24 and 48 h after beginning with alcohol consumption. In addition, urine samples were collected. Intestinal permeability was determined by serum and urine values of FABP-I, syndecan-1, and soluble (s)CD14 as a marker for the endotoxin translocation via the intestinal barrier by ELISA. BAC was determined. Results Systemic FABP-I was significantly reduced 2 h after the onset of alcohol drinking, and remained decreased after 4 h. However, at 6 h, FABP-I significantly elevated compared to previous measurements as well as to controls (p < 0.05). Systemic sCD14 was significantly elevated after 6, 24 and 48 h after the onset of alcohol consumption (p < 0.05). Systemic FABP-I at 2 h after drinking significantly correlated with the sCD14 concentration after 24 h indicating an enhanced systemic LPS bioactivity. Women showed significantly lower levels of syndecan-1 in serum and urine and urine for all time points until 6 h and lower FABP-I in the serum after 2 h. Conclusions Even relative low amounts of alcohol affect the immune system of healthy volunteers, although these changes appear minor in women. A potential damage to the intestinal barrier and presumed enhanced systemic endotoxin bioactivity after acute alcohol consumption is proposed, which represents a continuous immunological challenge for the organism and should be considered for the following days after drinking.

Categories of Alcohol Consumers

2010 ◽  
Vol 24 (4) ◽  
pp. 213-214
Author(s):  
Claude Tomberg
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Dependence ◽  
Alcohol Intoxication ◽  
Blood Alcohol ◽  
Acute Alcohol Intoxication ◽  
Common Pattern ◽  
Classification Schemes ◽  
Social Drinking ◽  
Blood Alcohol Levels ◽  
The Brain

Common patterns of alcohol consumption are described with their main criteria, blood alcohol levels, and diagnostic criteria. Binge drinking, an acute alcohol intoxication pattern of particularly concern, is also described, as it appears to be the most common pattern among teenagers when the brain is not yet mature. A number of classification schemes have been proposed specially for social drinking and alcohol dependence, and discussions still surround about them. The article summarize a consensus in classification.

scholarly journals Study of effects of blood alcohol consumption (BAC) level on drivers physiological behavior and driving performance under simulated environment

2018 ◽  
Vol 7 (2.8) ◽  
pp. 86
Author(s):  
Murali Subramaniyam ◽  
Seoung Eun Kim ◽  
Seung Nam Min ◽  
Heeran Lee ◽  
Seung Hee Hong ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Visual Information ◽  
Traffic Accidents ◽  
Alcohol Intoxication ◽  
Young Male ◽  
Driving Performance ◽  
Blood Alcohol ◽  
Driving Experience ◽  
Simulated Environment ◽  
Power Frequency

Alcohol consumption impairs driving skills and responsible for a high proportion of traffic accidents. This research examined the effects of blood alcohol consumption (BAC) level on driver’s physiological behavior and driving performance under simulated driving environment. The participants consisted of eight healthy young male drivers with an average of eight years driving experience. The scenario considered was 5 min driving on a highway with different speed limits, crossings, and unexpected event. Results showed that statistically significantly decreased alpha and increased theta power frequency was observed with increased BAC level. Heart rate was statistically significantly elevated with increased BAC level. The accident rate and the over speed rate were significantly higher with higher BAC level. Alcohol intoxication affected drivers’ decision-making ability, vision and integrating visual information ability.

scholarly journals ALCOHOL AND MORTALITY BY TRAUMA IN EUROPEAN COUNTRIES

2020 ◽  
Vol 1 (1) ◽  
pp. 3-6
Author(s):  
Daniel Ion ◽  
Georgiana Radu ◽  
Marina Leontescu ◽  
Dan Nicolae Păduraru ◽  
Alexandra Bolocan ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Intoxication ◽  
Blood Alcohol Concentration ◽  
Heavy Drinking ◽  
Alcohol Concentration ◽  
European Countries ◽  
Blood Alcohol ◽  
Per Capita ◽  
Positive Effect ◽  
Overall Mortality

Alcohol consumption alters one’s consciousness and may lead to accidents and traumatic events with deadly consequences. We aimed to analyze the most recent information available in WHO databases about overall mortality rates and alcohol consumption in European countries. The parameters taken into account were the total number of deaths by trauma, alcohol consumption per capita, prevalence of heavy drinking episodes and national legal blood alcohol concentration while drinking The mortality rate by trauma is influenced by many factors and alcohol intoxication could be one of them. Our analysis shows a moderate correlation between overall alchool consumption and death by trauma in Europe in 2015. There are studies who show a positive effect of alcohol consmption on the overall chance of survival after trauma. Chronic consumption is associated with an increase in mortality. Nonetheless, further research is needed and strongly encouraged.

scholarly journals Effects of body weight and alcohol consumption on insulin sensitivity

2010 ◽  
Vol 9 (1) ◽  
Author(s):  
Qiwei X Paulson ◽  
Jina Hong ◽  
Valerie B Holcomb ◽  
Nomeli P Nunez
Keyword(s):  
Body Weight ◽  
Insulin Sensitivity ◽  
Alcohol Consumption

ALCOHOL-INDUCED HYPOGLYCEMIA AND COMA CAUSED BY ALCOHOL SPONGING

PEDIATRICS ◽  
1970 ◽  
Vol 46 (3) ◽  
pp. 445-447
Author(s):  
Malcolm H. Moss
Keyword(s):  
Blood Glucose ◽  
Elevated Temperature ◽  
Ethyl Alcohol ◽  
Alcohol Intoxication ◽  
Severe Hypoglycemia ◽  
Male Infant ◽  
Blood Alcohol ◽  
Acute Alcohol Intoxication ◽  
Tepid Water

The inhalation of ethyl or isopropylalcohol vapor during sponge bathing may result in alcohol intoxication and coma. Ingestion of these alcohols may cause hypoglycemia in children or adults. The present case is the first reported in which alcohol-induced hypoglycemia developed following inhalation of alcohol. A six month-old male infant became comatose following sponge bathing with ethyl alcohol. He was found to have acute alcohol intoxication (blood alcohol 220 mg per 100 ml) and severe hypoglycemia (blood glucose 22 mg per 100 ml). The administration of 50% glucose in water intravenously resulted in prompt recovery. Alcohol sponging to lower elevated temperature is rarely necessary. Cooling with tepid water is effective and considerably less hazardous; the addition of alcohol is not necessary.

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