scholarly journals Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia.

1993 ◽  
Vol 69 (5) ◽  
pp. 577-579 ◽  
Author(s):  
L Lennard ◽  
B E Gibson ◽  
T Nicole ◽  
J S Lilleyman
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Thiopurine Methyltransferase

Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects

2005 ◽  
Vol 41 (4) ◽  
pp. 613-623 ◽  
Author(s):  
Connie Brouwer ◽  
Ronney A. De Abreu ◽  
Jenneke J. Keizer-Garritsen ◽  
Lambert H.J. Lambooy ◽  
Kai Ament ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Thiopurine Methyltransferase ◽  
Biological Aspects

Analysis of thiopurine methyltransferase variant alleles in childhood acute lymphoblastic leukaemia

1999 ◽  
Vol 105 (3) ◽  
pp. 696-700 ◽  
Author(s):  
Howard L. McLeod ◽  
Sally Coulthard ◽  
Angela E. Thomas ◽  
Stuart C. Pritchard ◽  
Derek J. King ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Thiopurine Methyltransferase ◽  
Childhood Acute Lymphoblastic Leukaemia ◽  
Variant Alleles

Influence of thiopurine methyltransferase gene polymorphism on Egyptian children with acute lymphoblastic leukaemia

2017 ◽  
Vol 96 (6) ◽  
pp. 905-910
Author(s):  
Azza A. G. Tantawy ◽  
Fatma S. E. Ebeid ◽  
Amira A. M. Adly ◽  
Eman El-Ghoroury ◽  
Mai Mostafa
Keyword(s):  
Gene Polymorphism ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Thiopurine Methyltransferase ◽  
Egyptian Children ◽  
Methyltransferase Gene

Screening for the P2RY8-CRLF2 fusion gene in childhood acute lymphoblastic leukaemia

2011 ◽  
Vol 223 (03) ◽  
Author(s):  
M Morak ◽  
R Joas ◽  
S Fischer ◽  
A Attarbaschi ◽  
G Mann ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Fusion Gene ◽  
Childhood Acute Lymphoblastic Leukaemia

Cerebral sinovenous thrombosis during asparaginase treatment

2003 ◽  
Vol 23 (03) ◽  
pp. 109-112
Author(s):  
A. Hirt ◽  
C. Zwicky ◽  
W.A. Wuillemin ◽  
K. Leibundgut
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Induction Treatment ◽  
Pathogenic Mechanisms ◽  
Cerebral Sinovenous Thrombosis ◽  
Haemorrhagic Infarction ◽  
Sinovenous Thrombosis

SummaryA boy (age: 71/12 years) with acute lymphoblastic leukaemia developed thrombosis of the sinus sagitalis superior with secondary haemorrhagic infarction while on induction treatment with vincristine, prednisone, and asparaginase. Based on this report, the potential pathogenic mechanisms are discussed with respect to congenital prothrombotic defects as well as to the role of antileukaemic treatment. Current hypotheses on mechanisms for thromboembolism in children and proposed prophylactic strategies are briefly summarized.

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