scholarly journals Urinary creatinine excretion in the newborn.

1989 ◽  
Vol 64 (2) ◽  
pp. 304-306 ◽  
Author(s):  
N Modi ◽  
J L Hutton
Keyword(s):  
Creatinine Excretion ◽  
Urinary Creatinine ◽  
Urinary Creatinine Excretion

Creatinine Excretion

PEDIATRICS ◽  
1983 ◽  
Vol 71 (1) ◽  
pp. 140-140
Author(s):  
JAMES L. SUTPHEN
Keyword(s):  
Muscle Mass ◽  
Initial Presentation ◽  
Creatinine Excretion ◽  
Urinary Creatinine ◽  
Weight Measurement ◽  
Body Muscle ◽  
Creatinine Measurement ◽  
Urinary Creatinine Excretion

In Reply.— The questions posed by Harkavy allow me to expand on the initial presentation of the data in my previous report.1 As documented by numerous previous reports, urinary creatinine excretion does, in fact, reflect body muscle mass.2 Furthermore, it has been documented in older infants that creatinine excretion per kilogram increases with the age, weight, and length of the infant.3 The regression data in my report are not expressed in terms of creatinine per kilogram as the dependent variable as this multiplies the error of creatinine measurement by including the error in weight measurement (hydration states etc).

Enzymuria as a Marker of Renal Injury and Disease: Studies of N-Acetyl-βglucosaminidase in the General Population and in Patients with Renal Disease

PEDIATRICS ◽  
1978 ◽  
Vol 62 (5) ◽  
pp. 751-760
Author(s):  
Calvin M. Kunin ◽  
Russell W. Chesney ◽  
William A. Craig ◽  
Albert C. England ◽  
Catherine DeAngelis
Keyword(s):  
Renal Disease ◽  
Small Body ◽  
Adult Life ◽  
Creatinine Ratio ◽  
Creatinine Excretion ◽  
Urinary Creatinine ◽  
Close Relationship ◽  
The Mean ◽  
Urine Specimens ◽  
Urinary Creatinine Excretion

Urinary excretion of N-acetyl-β-D-glucosaminidase (NAG) was shown to be reproducible in random urine specimens when expressed as the ratio of NAG to milligrams of urinary creatinine. The enzyme/creatinine ratio in 815 healthy people was relatively constant throughout childhood and adult life except for the first two years after birth and in individuals 56 years or greater. High ratios in the young children may be explained by low urinary creatinine excretion probably related to small body mass and reduced glomerular filtration rate at this age. The ratio was increased in adult uremic patients and children and adults with a variety of neurologic and obstructive lesions of the voiding mechanism. The presence of bacteriuria did not appear to increase the ratio. Significant enzymuria (> 2 SD above the mean for age and sex) was detected in 38 of 81 children with well-characterized renal disease. Among patients with predominantly glomerular disorders there was a close relationship between activity of the disease and enzymuria. In patients with tubulointerstitial disease enzymuria was frequent even in the absence of proteinuria. One of the highest enzyme/creatinine ratios was observed in a child with cystinosis. These studies indicate that NAG enzymuria is a sensitive indicator of activity of renal disease and may prove to be a suitable screening test for significant renal disease or injury in childhood.

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