scholarly journals Hyaline membrane disease and intraventricular haemorrhage in small for gestational age infants.

1980 ◽  
Vol 55 (7) ◽  
pp. 502-505 ◽  
Author(s):  
R S Procianoy ◽  
J A Garcia-Prats ◽  
J M Adams ◽  
A Silvers ◽  
A J Rudolph
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Intraventricular Haemorrhage ◽  
Hyaline Membrane Disease ◽  
Hyaline Membrane

scholarly journals Adverse effects of small for gestational age differ by gestational week among very preterm infants

2018 ◽  
Vol 104 (2) ◽  
pp. F192-F198 ◽  
Author(s):  
Erik A Jensen ◽  
Elizabeth E Foglia ◽  
Kevin C Dysart ◽  
Rebecca A Simmons ◽  
Zubair H Aghai ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Intraventricular Haemorrhage ◽  
Neonatal Morbidity ◽  
Excess Risk ◽  
Very Preterm Infants ◽  
Adjusted Risk ◽  
Very Preterm ◽  
Grade 3

ObjectiveTo characterise the excess risk for death, grade 3–4 intraventricular haemorrhage (IVH), bronchopulmonary dysplasia (BPD) and stage 3–5 retinopathy of prematurity independently associated with birth small for gestational age (SGA) among very preterm infants, stratified by completed weeks of gestation.MethodsRetrospective cohort study using the Optum Neonatal Database. Study infants were born <32 weeks gestation without severe congenital anomalies. SGA was defined as a birth weight <10th percentile. The excess outcome risk independently associated with SGA birth among SGA babies was assessed using adjusted risk differences (aRDs).ResultsOf 6708 infants sampled from 717 US hospitals, 743 (11.1%) were SGA. SGA compared with non-SGA infants experienced higher unadjusted rates of each study outcome except grade 3–4 IVH among survivors. The excess risk independently associated with SGA birth varied by outcome and gestational age. The highest aRD for death (0.27; 95% CI 0.13 to 0.40) occurred among infants born at 24 weeks gestation and declined as gestational age increased. In contrast, the peak aRDs for BPD among survivors (0.32; 95% CI 0.20 to 0.44) and the composites of death or BPD (0.35; 95% CI 0.24 to 0.46) and death or major morbidity (0.35; 95% CI 0.24 to 0.45) occurred at 27 weeks gestation. The risk-adjusted probability of dying or developing one or more of the evaluated morbidities among SGA infants was similar to that of non-SGA infants born approximately 2–3 weeks less mature.ConclusionThe excess risk for neonatal morbidity and mortality associated with being born SGA varies by adverse outcome and gestational age.

scholarly journals The burden of hyaline membrane disease, mortality and its determinant factors among preterm neonates admitted at Debre Tabor General Hospital, North Central Ethiopia: A retrospective follow up study

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0249365
Author(s):  
Binyam Minuye Birihane ◽  
Wubet Alebachew Bayih ◽  
Abebaw Yeshambel Alemu ◽  
Demeke Mesfin Belay ◽  
Asmamaw Demis
Keyword(s):  
Gestational Age ◽  
Neonatal Intensive Care ◽  
Preterm Neonate ◽  
Hyaline Membrane Disease ◽  
Preterm Neonates ◽  
P Value ◽  
North Central ◽  
Disease Mortality ◽  
Hyaline Membrane

Background Hyaline membrane disease (HMD) is a leading cause of morbidity and mortality in preterm newborn babies. Though, there are studies related to Hyaline membrane disease inclusive of all neonates, studies related to the burden among preterm neonates were limited. In addition, increasing neonatal mortality in Ethiopia could be related to increase in the burden of hyaline membrane disease among preterm neonates. Therefore, this study was aimed to assess the burden of hyaline membrane disease, mortality and its associated factors among preterm neonate admitted at neonatal intensive care unit, North Central Ethiopia. Methodology An institution-based retrospective follow-up study was conducted among 535 preterm neonates admitted at neonatal intensive care unit from January 1, 2014-December 30, 2017. Data were entered into EPi-data 4.2.0.0 and transferred to STATA version 14 statistical software for statistical analysis. Binary logistic regression was used for the analysis. All variables with P-value < 0.25 during bi-variable analysis were considered for multivariable logistic regression. Level of statistical significance was declared at P value ≤0.05. Results In the current study, proportion of hyaline membrane disease was 40% (95% CI; 35.8, 44.3) of which 49.5% died. Preterm neonate born with Gestational age of less than 34 weeks of age (Adjusted odd ratio (AOR = 2.64; 95 CI: 1.49, 4.66)), 5th minute Apgar score less than 7 (AOR = 2.2; 95% CI: 1.20, 4.07), and newborn with birth weight of less than 1500 gram (AOR = 2.4, 95% CI: 1.3, 4.3) were predictors of hyaline membrane disease. Conclusions The mean gestational age (±) was 33.46 (±2.55) weeks. The incidence of hyaline membrane disease among preterm admissions was high. Preterm neonate born with gestational age of less than 34 weeks of age, asphyxiated newborns and newborn with birth weight of less than 1500 gram were predictors of hyaline membrane disease. So, emphasis should be given on early screening, follow up and timely interventions for preterm neonate.

HYALINE-MEMBRANE DISEASE, ALKALINE BUFFER TREATMENT, AND CEREBRAL INTRAVENTRICULAR HÆMORRHAGE

The Lancet ◽  
1976 ◽  
Vol 307 (7951) ◽  
pp. 117-119 ◽  
Author(s):  
J.M. Anderson ◽  
F. Cockburn ◽  
A.D. Bain ◽  
J.O. Forfar ◽  
T.L. Turner ◽  
...  
Keyword(s):  
Intraventricular Haemorrhage ◽  
Hyaline Membrane Disease ◽  
Hyaline Membrane

scholarly journals Intraventricular haemorrhage in the preterm infant without hyaline membrane disease.

1977 ◽  
Vol 52 (6) ◽  
pp. 447-451 ◽  
Author(s):  
J S Wigglesworth ◽  
P A Davies ◽  
I H Keith ◽  
S A Slade
Keyword(s):  
Preterm Infant ◽  
Intraventricular Haemorrhage ◽  
Hyaline Membrane Disease ◽  
Hyaline Membrane

scholarly journals Risk Factors for the Development of Hyaline Membrane Disease in Preterm Infants

2017 ◽  
Vol 38 (11-12) ◽  
pp. 243
Author(s):  
Sudigdo Sastroasmoro
Keyword(s):  
Risk Factors ◽  
Cigarette Smoking ◽  
Preterm Infants ◽  
Gestational Age ◽  
Apgar Score ◽  
Maternal Morbidity ◽  
Hyaline Membrane Disease ◽  
Obstetrics And Gynecology ◽  
Hyaline Membrane ◽  
Minute Apgar Score

Hyaline membrane disease (HMO) is a respiratory disease commonly found in preterm infants. While this disease occurs as the result of surfactant deficiency which is a function of gestational age, certain maternal and neonatal factors play a role in the development of the disorder. Preterm infants born at the Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Jakarta, between, March 1997 and May 1998 were studied for the development of HMO. It was concluded that antepartum hemorrhage, gestational age, sex, mod of birth, and the first minute Apgar score were associated with the development of HMD, while the use of contraceptives, early rupture of the membrane, maternal morbidity, and passive cigarette smoking were not.

scholarly journals Outcome of Surfactant Replacement Therapy in Preterm Babies with Hyaline Membrane Disease at Neonatal Intensive Care Unit of a Tertiary Hospital

2019 ◽  
Vol 3 (3) ◽  
pp. 537-541
Author(s):  
Sunil Raja Manandhar
Keyword(s):  
Birth Weight ◽  
Replacement Therapy ◽  
Gestational Age ◽  
College Teaching ◽  
Hyaline Membrane Disease ◽  
Medical College ◽  
Surfactant Replacement ◽  
Surfactant Replacement Therapy ◽  
Hyaline Membrane ◽  
Preterm Babies

Introduction: Hyaline membrane disease (HMD) is an acute lung disease of preterm babies caused by surfactant insufficiency. Decreased surfactant results in insufficient surface tension in the alveolus during expiration leading to alveolar collapse, atelectasis, impaired gas exchange, severe hypoxia and acidosis, leading to respiratory failure. Surfactant replacement therapy (SRT) is now accepted as the standard treatment of preterm babies with HMD. Objective: The objective of this study was to analyze the outcome of surfactant replacement therapy in preterm babies with hyaline membrane disease. Methodology: This is a prospective observational study conducted at 10 bedded neonatal unit of Pediatrics Department, Kathmandu Medical College Teaching Hospital, Sinamangal. Study duration was of one year period (15 May 2017 – 14 May 2018). Preterm babies from 26 wks–35 wks of gestation with Hyaline Membrane Disease were included in this study whereas babies with lethal congenital malformations eg: Meningomyelocele, Anencephaly, Gastrochisis, Diaphragmatic Hernia were excluded. All preterm babies who had clinical and radiological features of HMD were considered for Surfactant Replacement Therapy (SRT). The surfactant (Survanta; Abboti Laboratories, USA; Dose: 4 ml/kg) was administered intra-tracheally according to standard procedures in four divided aliquot applying INSURE (intubation, surfactant administration and extubation to Bubble CPAP) Technique. Ethical clearance was received from Institutional Review Committee (IRC) of Kathmandu Medical College and Statistical analysis was done with SPSS 19 version with frequency and cross tabulation. Results: In this study of 30 preterm babies with HMD received SRT, 47% (14) were male and 53% (16) were female. The mean birth weight of preterm babies with HMD was 1372.17 ± 395 gms and mean gestational age was 30.1±2.6 weeks. Among 30 preterm babies with HMD receiving SRT, 73.3% (22 babies) discharged from the hospital and 6.3% (8 babies) expired. Among eight expired babies, five died due to pulmonary hemorrhage and three died due to septicemia with DIC. Maximum survival was seen in the gestational age of 30-35 wks and birth weight 1200-2100gms. Conclusion: The use of SRT has improved the survival outcome and decreased the associated morbidities in babies with HMD. The maximum impact of survival was seen among the preterm babies of 30- 35 weeks with birth weight of 1200 -2100 grams. 

scholarly journals Use of early nasal continuous positive airway pressure in preterm neonates with hyaline membrane disease (neonatal respiratory distress syndrome)

2021 ◽  
Vol 8 (3) ◽  
pp. 488
Author(s):  
R. D. M. Suresh Reddy ◽  
Seshagiri Koripadu ◽  
Harischandra Venkata Yanamandala
Keyword(s):  
Continuous Positive Airway Pressure ◽  
Respiratory Distress ◽  
Success Rate ◽  
Gestational Age ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Hyaline Membrane Disease ◽  
Nasal Cpap ◽  
Antenatal Steroids ◽  
Hyaline Membrane

Background: In developing countries like ours, there is high burden of prematurity and sub-optimal use of antenatal steroid administration resulting infrequent hyaline membrane disease (HMD).Methods: A total 50 cases of clinically diagnosed HMD with gestational age between 28-34 weeks admitted to neonatal intensive care unit (ICU). 50 babies were treated with early nasal continuous positive airway pressure (CPAP) (within 6 hours of onset of respiratory distress).Results: Incidence of prematurity was 12.42%. Incidence of HMD observed between gestational ages of 28-34 weeks is 3.2%. Out of total 50 babies who were managed with early nasal CPAP, it proved effective in 40 babies (80%), remaining 10 babies (20%) had to be intubated and required ventilation. Out of 10 babies who required ventilation 90% of the babies were less than 32 weeks gestation age; remaining 10% were between 33-34 weeks. Analysis of these results showed that outcome is better with increased gestational age (p<0.005). Out of 10 babies who failed 80% were <1500 g and remaining 20% above 1500 g. We found significant improvement (p<0.005) in SA score after application of nasal CPAP. Babies on CPAP had significant improvement in oxygenation (p<0.05). A success rate of 93.1% observed in moderate grade HMD (p<0.005). Out of 10 babies who failed on nasal CPAP, 80% of them had severe grade HMD and 20% showed moderate HMD. A success rate of 92.86% was found in babies of mothers who had received antenatal steroids and 63.63% of babies whose mothers had not received antenatal steroids improved with early nasal CPAP (p<0.05).Conclusions: Nasal CPAP is found to be effective in babies of mothers who had received antenatal steroids. Nasal CPAP is safe, inexpensive and effective means of respiratory support in HMD. Use of early nasal CPAP which is simple, non-invasive, has low capital outlay and does not require expertise, is the option for us where most places cannot provide invasive ventilation.

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